E. Coli Genome Reported: Milestone Of Modern Biology Emerges From Wisconsin Lab

by Blattner's team rose to prominence as an experimental organism in 1945 when it was used in the discovery of spontaneous gene transfer or bacterial sex. As a result, the strain, known as K-12, was universally adopted for fundamental work in biochemistry, genetics and physiology. In recent years, it has become the workhorse of biotechnology and is used as a living factory to produce human insulin and other medicines.

The most important result of the work reported today is the sequence itself, said Blattner. In January, the data were made freely available through on-line databases such as GenBank to scientists worldwide. The E. coli genome is a huge one, and required an additional nine months to describe in detail in Science. With more than 4.6 million bases, it is two or three times bigger than other bacteria sequenced to date.

Sequencing of the base pairs that make up DNA is analogous to deciphering a language. It is done with the aid of specialized chemical analysis machines, but can only be accomplished with considerable human effort. More than 269 people - including many undergraduates getting their first taste of science - participated in the project at the UW-Madison.

The individual chemical bases that make up the genome correspond to the letters of the genetic alphabet which, grouped into words and paragraphs corresponding to genes, are read by the living cell as the instructions for assembly and function of all of life's processes.

Knowledge of the genetic code, a major effort of modern biology, permits the scientist to translate the instructions for the purpose of understanding life processes, Blattner said. Knowing the precise order of the chemical base pairs for an entire genome allows the encoded life program to be read in its entirety leading, in principle, to a very complete level of understanding of physiological processes.

The report published in this issue of Science is a global analysis of the data collected by Blattner's team in c

Contact: Terry Devitt
University of Wisconsin-Madison

Page: 1 2 3 4

Related biology news :

1. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
2. Genome-wide screen reveals new tricks of old genes
3. Genome of first fungal pathogen unveiled
4. Experimental Biology 2004 - Translating the Genome
5. European Virtual Institute for Genome Annotation receives 12 million Euro
6. Tools from the Human Genome Project reveal a versatile microbe
7. Francis Collins and Ari Patrinos receive Energy Secretarys Gold Award for Human Genome Project
8. Genomes of tiny microbes yield clues to global climate change
9. Genome researcher analyze chromosome 7
10. Genome sequence of bread mold revealed by international team, including Hebew University researcher
11. Genome analysis sheds light on drug-resistant pathogen

Post Your Comments:

(Date:4/24/2017)... WASHINGTON , April 24, 2017 ... counsel and partner with  Identity Strategy Partners, LLP ... "With or without President Trump,s March 6, ... Foreign Terrorist Entry , refugee vetting can be instilled ... refugee resettlement. (Right now, all refugee applications are ...
(Date:4/17/2017)... MELBOURNE, Florida , April 17, 2017 ... security technology company, announces the filing of its 2016 Annual Report ... Securities and Exchange Commission. ... Report on Form 10-K is available in the Investor Relations section ... well as on the SEC,s website at http://www.sec.gov . ...
(Date:4/11/2017)... PALM BEACH GARDENS, Fla. , April 11, ... biometric identity management and secure authentication solutions, today ... million contract by Intelligence Advanced Research Projects Activity ... technologies for IARPA,s Thor program. "Innovation ... the onset and IARPA,s Thor program will allow ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and ... San Diego Rotary Club. The event entitled “Stem Cells and Their ... 300+ attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: Peter ...
(Date:10/10/2017)... 2017 SomaGenics announced the receipt of a ... RealSeq®-SC (Single Cell), expected to be the first commercially ... microRNAs) from single cells using NGS methods. The NIH,s ... accelerate development of approaches to analyze the heterogeneity of ... techniques for measuring levels of mRNAs in individual cells ...
(Date:10/10/2017)... ... 2017 , ... The Pittcon Program Committee is pleased to ... who have made outstanding contributions to analytical chemistry and applied spectroscopy. Each award ... conference and exposition for laboratory science, which will be held February 26-March 1, ...
(Date:10/9/2017)... , ... October 09, 2017 , ... The award-winning American ... broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , ... faced with the challenge of how to continue to feed a growing nation. At ...
Breaking Biology Technology:
Cached News: