HOME >> BIOLOGY >> NEWS
E. coli bacteria make Alzheimers-linked fibers

wth of the snowflake.

Curli production in E. coli involves two main proteins, CsgA and CsgB. The A protein is released by the bacteria dissolved in the surrounding fluid. The B molecule is embedded in the wall of the bacterium and is exposed to the outside. Like dust particles in snowflake production, each B protein is a nucleus that triggers the precipitation of dissolved A-proteins. As the A proteins pop out of solution they join together and align into curli fibers, with each fiber attached to a B protein.

The finding also raises the important question of whether bacterial infections play some role in amyloid diseases, including Alzheimers disease.

Human amyloid diseases also are thought to involve dissolved amyloid proteins that undergo a change in shape and aggregate into fibers, says Hultgren. When those fibers develop in the brain, it leads to Alzheimers disease. According to Hultgren, the question is, what causes the soluble protein in human disease to convert into amyloid fibers? We can now study that mechanism in E. coli.

Hultgren and Chapman speculate that bacterial infections could play a role in the development of amyloid plaques in Alzheimers disease and other amyloid diseases in at least two ways.

Bacteria might contribute directly to plaque formation through the amyloid they produce, says Chapman, or they might contribute indirectly by triggering the precipitation of amyloid precursor proteins already present in the body. Hultgren and his research team also are working to crystallize the combined A and B proteins to visualize how the two molecules interact.

Learning that bacteria produce amyloid is a revelation, says Paul Berg, Cahill Professor of Cancer Research and Biochemistry, Emeritus, at Stanford University School of Medicine and winner of the 1980 Nobel Prize in Chemistry.

That discovery provides an additional vantage point from which to assess the role of amyloid production and
'"/>

Contact: Darrell E. Ward
wardd@msnotes.wustl.edu
314-286-0122
Washington University School of Medicine
31-Jan-2002


Page: 1 2 3

Related biology news :

1. Researchers find color sensitive atomic switch in bacteria
2. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
3. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
4. Scientists discover potential new way to control drug-resistant bacteria
5. 22nd amino acid synthesized and added to genetic code of e. coli bacteria
6. Missing genes may help explain why plague bacteria are so deadly
7. Complex cells likely arose from combination of bacterial and extreme-microbe genomes
8. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
9. UC Irvine scientists to develop vaccine to combat bioterrorism threat from deadly bacteria
10. UV light, coatings reduce bacterial adhesion up to 50 percent
11. PCB breakdown in rivers depends on sediment-specific bacteria, find Carnegie Mellon U. scientists

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/10/2019)... ... October 09, 2019 , ... ... Inc., the creators of CRISPR-Chip™. Cardea first broke the news of ... Program for the Genome Sensor™. Built with CRISPR-Chip technology, the Genome Sensor is ...
(Date:10/8/2019)... ... October 08, 2019 , ... ... a collaboration with the National Research Council of Canada (NRC) to create ... nanofabrication and lab-on-a-chip technologies and in manufacturing, LIFT will offer a competitive ...
(Date:10/8/2019)... ... ... The future of medicine in the 21st century will focus on wellness, ... lives. But it will be up to each individual to make healthy choices and ... Officer and Co-Founder of the Institute for Systems Biology and Senior Vice President and ...
Breaking Biology News(10 mins):
(Date:9/17/2019)... WHITEHOUSE STATION, N.J. (PRWEB) , ... September 16, 2019 , ... ... tissue clearing reagents and kits that allow for the complete 3D characterization of tissues ... years, Visikol has transitioned into an imaging, image analysis and advanced cell culture focused ...
(Date:9/11/2019)... Pa. (PRWEB) , ... September 09, 2019 , ... ... for life sciences companies and government agencies, announced that its president and CEO ... group of successful business leaders. , The Forbes Council accepted Gallivan based on ...
(Date:9/11/2019)... (PRWEB) , ... September 10, 2019 , ... ... and manufacturing solutions for drugs, biologics, gene therapies, and consumer health products, today ... to be held at the Bausparkasse Schwäbisch Hall AG, Schwabisch Hall, Germany, on ...
(Date:9/8/2019)... , ... September 05, 2019 , ... ... Blaine Fitzgerald, former Vice President of Finance for Shopify, has been named Chief ... and healthcare venture capitalist Joel Finlayson as strategic advisors. Additionally, Spartan has hired ...
Breaking Biology Technology:
Cached News: