HOME >> BIOLOGY >> NEWS
ER stress in inflammatory bowel disease

Products of the IRE1 genes, which are conserved from yeast to mammals, respond to the accumulation of unfolded proteins in the endoplasmic reticulum and mediate the so-called ER stress response, by which chaperone proteins are induced and targeted to the ER. This pathway, mediated in most cells by the ubiquitously expressed Ire1a protein, is essential for mouse development but the related protein Ire1b has not been carefully studied. Bertoletti and colleagues have now generated mice lacking this isoform, which prove to be grossly normal and fertile (okay?). Taking a cue from the highly restricted expression of Ire1b, which is found in the stomach and intestines, the authors examined the mutant mice for a defect in the GI tract. The gastric epithelium appears normal in Ire1b-/-animals but is hypersensitive to the effects of dextran sodium sulfate (DSS), an irritant that induces the ER stress response and provokes symptoms of inflammatory bowel disease in mice. Epithelial cells in mutant mice have higher baseline levels of the ER resident chaperone protein BiP and of the protective MAP kinase pathway, which acts in both the unfolded protein response in the ER and in similar cytoplasmic pathways, as expected if the absence of Ire1b is required for homeostasis in response to increased levels of unfolded proteins in the secretory pathway. Evidently, Ire1a and other sensors proteins can activate some aspects of the normal unfolded protein responses, but they are not sufficient to protect the cells from damage in the absence of Ire1b.


'"/>

Contact: John Ashkenas
scied@the-jci.org
416-946-7593
Journal of Clinical Investigation
27-Feb-2001


Page: 1

Related biology news :

1. UCSD team determines cellular stress within body is critical
2. Genetic basis for individual variations in the response to stress
3. Memory fails you after severe stress
4. Need sex? Its probably something about stress
5. Mix of chemicals plus stress damages brain, liver in animals and likely in humans
6. Researchers-again-pinpoint why stress kills
7. Social stress adversely affects digestive function in subordinate cichlid fish
8. Hebrew University, German and British researchers develop means to help stress sufferers
9. A little stress may be good for you
10. Estrogen promotes gender differences in brains response to stress
11. Study finds new mothers are resistant to stress

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: stress inflammatory bowel disease

(Date:4/27/2015)... , April 27, 2015  For more than ... trade show has been the premier worldwide event for ... 2015 is a must-attend event for any local, national, ... into the emerging commercial markets and current applications of ... innovations of this projected $48 billion industry, and how ...
(Date:4/27/2015)... LAUDERDALE, Fla. , Apr. 27, 2015 ... of access control and security systems is pleased to ... the company as a consultant and member of its ... is widely known as a thought leader in ... Distance Learning Technology Group, and has published studies and ...
(Date:4/20/2015)... PASADENA, Calif. , April 20, 2015 ... San Gabriel Valley to implant a new miniaturized, wireless ... HF System is the first and only FDA-approved heart ... reduce hospital admissions when used by physicians to manage ... a sensor that is implanted in the pulmonary artery ...
Breaking Biology News(10 mins):UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3
(Date:5/27/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/8nqqdw/global_breast ) has announced ... Monoclonal Antibodies Market Outlook 2020" report to ... dominate the breast cancer monoclonal antibody segment because ... has been able to dominate this segment for ... cells become recalcitrant and relapsed condition could not ...
(Date:5/27/2015)... Expanding in a big way into ... Biomed Inc. recently inked a deal with Arthur ... Ltd. , the largest endodontic distributor in Japan. The ... for Avalon Biomed, which manufactures Grey MTA Plus® and ... cements that have won renown from dentists around the ...
(Date:5/27/2015)... AVIV, Israel , May 27, 2015  Tikcro ... first quarter ended March 31, 2015. ... the quarter, we continued pre-clinical work to generate functional ... in an early stage, we are encouraged by the ... this field as new antibodies which modulate immune checkpoints ...
(Date:5/27/2015)... (PRWEB) May 27, 2015 Empowering ... to combat disease, Cubresa Inc. today announced its ... MR Compatible in-bore PET Scanner uses silicon photomultiplier ... single-purpose preclinical MRI machines from manufacturers like Bruker ... headquartered in Winnipeg, Canada. “This enables simultaneous PET ...
Breaking Biology Technology:Global Breast Cancer Monoclonal Antibodies Market Outlook 2020 2Global Breast Cancer Monoclonal Antibodies Market Outlook 2020 3Dental Manufacturer Avalon Biomed Inks Major Deal with Japanese Distributor 2Dental Manufacturer Avalon Biomed Inks Major Deal with Japanese Distributor 3Tikcro Technologies Reports First Quarter 2015 Results 2Tikcro Technologies Reports First Quarter 2015 Results 3Cubresa Launches Simultaneous PET/MRI Technology 2
Cached News: