HOME >> BIOLOGY >> NEWS
ER stress in inflammatory bowel disease

Products of the IRE1 genes, which are conserved from yeast to mammals, respond to the accumulation of unfolded proteins in the endoplasmic reticulum and mediate the so-called ER stress response, by which chaperone proteins are induced and targeted to the ER. This pathway, mediated in most cells by the ubiquitously expressed Ire1a protein, is essential for mouse development but the related protein Ire1b has not been carefully studied. Bertoletti and colleagues have now generated mice lacking this isoform, which prove to be grossly normal and fertile (okay?). Taking a cue from the highly restricted expression of Ire1b, which is found in the stomach and intestines, the authors examined the mutant mice for a defect in the GI tract. The gastric epithelium appears normal in Ire1b-/-animals but is hypersensitive to the effects of dextran sodium sulfate (DSS), an irritant that induces the ER stress response and provokes symptoms of inflammatory bowel disease in mice. Epithelial cells in mutant mice have higher baseline levels of the ER resident chaperone protein BiP and of the protective MAP kinase pathway, which acts in both the unfolded protein response in the ER and in similar cytoplasmic pathways, as expected if the absence of Ire1b is required for homeostasis in response to increased levels of unfolded proteins in the secretory pathway. Evidently, Ire1a and other sensors proteins can activate some aspects of the normal unfolded protein responses, but they are not sufficient to protect the cells from damage in the absence of Ire1b.


'"/>

Contact: John Ashkenas
scied@the-jci.org
416-946-7593
Journal of Clinical Investigation
27-Feb-2001


Page: 1

Related biology news :

1. UCSD team determines cellular stress within body is critical
2. Genetic basis for individual variations in the response to stress
3. Memory fails you after severe stress
4. Need sex? Its probably something about stress
5. Mix of chemicals plus stress damages brain, liver in animals and likely in humans
6. Researchers-again-pinpoint why stress kills
7. Social stress adversely affects digestive function in subordinate cichlid fish
8. Hebrew University, German and British researchers develop means to help stress sufferers
9. A little stress may be good for you
10. Estrogen promotes gender differences in brains response to stress
11. Study finds new mothers are resistant to stress

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/20/2016)... 20, 2016 Securus Technologies, a leading ... for public safety, investigation, corrections and monitoring announced ... it has secured the final acceptance by all ... Managed Access Systems (MAS) installed. Furthermore, Securus will ... be installed by October, 2016. MAS distinguishes between ...
(Date:6/9/2016)... TURKU, Finland , June 9, 2016 ... French National Police deploy Teleste,s video security solution to ensure ... France during the major tournament ... and data communications systems and services, announced today that its ... Police Prefecture to back up public safety across ...
(Date:6/2/2016)... 2, 2016   The Weather Company , an IBM ... an industry-first capability in which consumers will be able to ... ask questions via voice or text and receive relevant information ... Marketers have long sought an advertising solution that ... be personal, relevant and valuable; and can scale across millions ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Apellis ... Phase 1 clinical trials of its complement C3 ... single and multiple ascending dose studies designed to ... (PD) of subcutaneous injection in healthy adult volunteers. ... (SC) either as a single dose (ranging from ...
(Date:6/23/2016)... 23, 2016 Andrew ... http://doi.org/10.17925/OHR.2016.12.01.22 Published recently in ... journal from touchONCOLOGY, Andrew D Zelenetz , ... cancer care is placing an increasing burden on ... biologic therapies. With the patents on many biologics ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... at the Pennsylvania Convention Center and will showcase its product’s latest features from ... also be presenting a scientific poster on Disrupting Clinical Trials in The Cloud ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity Products, ... tools designed, tuned and optimized exclusively for Okuma CNC machining centers at The ... of a collaboration among several companies with expertise in toolholding, cutting tools, machining ...
Breaking Biology Technology:
Cached News: