HOME >> BIOLOGY >> NEWS
ER stress in inflammatory bowel disease

Products of the IRE1 genes, which are conserved from yeast to mammals, respond to the accumulation of unfolded proteins in the endoplasmic reticulum and mediate the so-called ER stress response, by which chaperone proteins are induced and targeted to the ER. This pathway, mediated in most cells by the ubiquitously expressed Ire1a protein, is essential for mouse development but the related protein Ire1b has not been carefully studied. Bertoletti and colleagues have now generated mice lacking this isoform, which prove to be grossly normal and fertile (okay?). Taking a cue from the highly restricted expression of Ire1b, which is found in the stomach and intestines, the authors examined the mutant mice for a defect in the GI tract. The gastric epithelium appears normal in Ire1b-/-animals but is hypersensitive to the effects of dextran sodium sulfate (DSS), an irritant that induces the ER stress response and provokes symptoms of inflammatory bowel disease in mice. Epithelial cells in mutant mice have higher baseline levels of the ER resident chaperone protein BiP and of the protective MAP kinase pathway, which acts in both the unfolded protein response in the ER and in similar cytoplasmic pathways, as expected if the absence of Ire1b is required for homeostasis in response to increased levels of unfolded proteins in the secretory pathway. Evidently, Ire1a and other sensors proteins can activate some aspects of the normal unfolded protein responses, but they are not sufficient to protect the cells from damage in the absence of Ire1b.


'"/>

Contact: John Ashkenas
scied@the-jci.org
416-946-7593
Journal of Clinical Investigation
27-Feb-2001


Page: 1

Related biology news :

1. UCSD team determines cellular stress within body is critical
2. Genetic basis for individual variations in the response to stress
3. Memory fails you after severe stress
4. Need sex? Its probably something about stress
5. Mix of chemicals plus stress damages brain, liver in animals and likely in humans
6. Researchers-again-pinpoint why stress kills
7. Social stress adversely affects digestive function in subordinate cichlid fish
8. Hebrew University, German and British researchers develop means to help stress sufferers
9. A little stress may be good for you
10. Estrogen promotes gender differences in brains response to stress
11. Study finds new mothers are resistant to stress

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: stress inflammatory bowel disease

(Date:6/25/2015)... , June 25, 2015  Imagine a tool ... toward a healthier, happier life. That,s exactly what USANA,s ... to do. The cutting-edge, portable health program provides a ... solutions to help improve your lifestyle and nutrition. ... dinner and gala Wednesday night, USANA,s THA was honored ...
(Date:6/24/2015)... Calif. , June 24, 2015  Synaptics ... of human interface solutions, today announced that Sharp ... to provide secure authentication for its latest flagship ... reached more than 200 million shipments of its ... Sharp reinforces Synaptics, strength, scalability and leadership in ...
(Date:6/23/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/vq2k2f/bodyworn ... "Body-Worn Temperature Sensors Market - Global Industry Analysis, ... 2020" report to their offering. ... body-worn temperature sensors market. The global body-worn temperature ... of types, care setting, patient demographic, applications and ...
Breaking Biology News(10 mins):@USANAinc's Personalized Nutrition Program Wins Industry Innovation Award 2Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2Body-Worn Temperature Sensors Market - Global Industry Analysis 2
(Date:7/2/2015)... ... 02, 2015 , ... Sleepless nights will become obsolete as Luzi , ... Indiegogo campaign on June 23. Sound sleepers and the sleep deprived both will love ... use, while the integration of the Bluetooth speaker, alarm clock and ability to charge ...
(Date:7/1/2015)... July 1, 2015   Decision Resources Group ... advantages of Otezla are its oral administration, alternative ... reported by surveyed rheumatologists. Otezla was the first ... treatment of active psoriatic arthritis in ... of care includes conventional oral treatments including disease-modifying ...
(Date:7/1/2015)...  Axovant Sciences Ltd. (NYSE:  AXON), a leading ... dementia, today announced that the company will host ... p.m. EDT following its presentation of RVT-101 clinical ... (AAIC). The event will include ... Lawrence Friedhoff , Chief Development Officer, will present ...
(Date:7/1/2015)... ... July 01, 2015 , ... Apex Therapeutics announced today that ... in Philadelphia, PA. , The presentation took place on Tuesday, June 16 ... for the development of APX3330 for the treatment of pancreatic cancer. A copy ...
Breaking Biology Technology:Luzi Smart Lamp Recently Launched Indiegogo Campaign 2Luzi Smart Lamp Recently Launched Indiegogo Campaign 3Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 2Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 3Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 2Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 3Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2
Cached News: