HOME >> BIOLOGY >> NEWS
ER stress in inflammatory bowel disease

Products of the IRE1 genes, which are conserved from yeast to mammals, respond to the accumulation of unfolded proteins in the endoplasmic reticulum and mediate the so-called ER stress response, by which chaperone proteins are induced and targeted to the ER. This pathway, mediated in most cells by the ubiquitously expressed Ire1a protein, is essential for mouse development but the related protein Ire1b has not been carefully studied. Bertoletti and colleagues have now generated mice lacking this isoform, which prove to be grossly normal and fertile (okay?). Taking a cue from the highly restricted expression of Ire1b, which is found in the stomach and intestines, the authors examined the mutant mice for a defect in the GI tract. The gastric epithelium appears normal in Ire1b-/-animals but is hypersensitive to the effects of dextran sodium sulfate (DSS), an irritant that induces the ER stress response and provokes symptoms of inflammatory bowel disease in mice. Epithelial cells in mutant mice have higher baseline levels of the ER resident chaperone protein BiP and of the protective MAP kinase pathway, which acts in both the unfolded protein response in the ER and in similar cytoplasmic pathways, as expected if the absence of Ire1b is required for homeostasis in response to increased levels of unfolded proteins in the secretory pathway. Evidently, Ire1a and other sensors proteins can activate some aspects of the normal unfolded protein responses, but they are not sufficient to protect the cells from damage in the absence of Ire1b.


'"/>

Contact: John Ashkenas
scied@the-jci.org
416-946-7593
Journal of Clinical Investigation
27-Feb-2001


Page: 1

Related biology news :

1. UCSD team determines cellular stress within body is critical
2. Genetic basis for individual variations in the response to stress
3. Memory fails you after severe stress
4. Need sex? Its probably something about stress
5. Mix of chemicals plus stress damages brain, liver in animals and likely in humans
6. Researchers-again-pinpoint why stress kills
7. Social stress adversely affects digestive function in subordinate cichlid fish
8. Hebrew University, German and British researchers develop means to help stress sufferers
9. A little stress may be good for you
10. Estrogen promotes gender differences in brains response to stress
11. Study finds new mothers are resistant to stress

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2017)... 17, 2017 NXT-ID, Inc. (NASDAQ: NXTD ... filing of its 2016 Annual Report on Form 10-K on Thursday ... ... available in the Investor Relations section of the Company,s website at ... website at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
(Date:4/5/2017)... KEY FINDINGS The global market for stem ... 25.76% during the forecast period of 2017-2025. The rise ... growth of the stem cell market. Download ... The global stem cell market is segmented on the ... cell market of the product is segmented into adult ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... OXFORD, England , Aug. 16, 2017 /PRNewswire/ ... biotech executive search and leadership development, and Virdis Group, global ... created an exclusive alliance that enables clients to leverage the ... "For our clients here in the ... to a diverse population of leadership talent throughout the US, ...
(Date:8/15/2017)... ... August 15, 2017 , ... Nanomedical Diagnostics , ... development, announces the launch of the new NHS Agile biosensor chip . ... data for a wide range of molecules, including small and large molecules, peptides, ...
(Date:8/15/2017)... ... August 15, 2017 , ... Kenall, a leader in ... to stay tightly sealed and perform efficiently for years. The downlights are ideal ... just aren't enough, such as: hospitals; behavioral health facilities; cleanrooms; containment areas; food ...
(Date:8/15/2017)... ... August 15, 2017 , ... ... Now mobile responsive, the new website makes it easy to navigate through the ... Users can now find detailed product information, educational industry content and visit the ...
Breaking Biology Technology:
Cached News: