HOME >> BIOLOGY >> NEWS
ES cell model could provide clues to causes, cures for diabetes

MADISON - By studying embryonic stem cells from a mouse, researchers at the University of Wisconsin-Madison have identified a potential model system for elucidating the stages of normal pancreatic development, as well as for developing a much-needed source of insulin-producing cells for the millions of people who need them to treat their diabetes.

The findings are published in the July 25 issue of Diabetes, the journal of the American Diabetes Association (ADA).

The ADA estimates that 17 million people in the United States have diabetes. Between five and 10 percent of them are younger than 20 years old and have a form of this disease called Type I diabetes. This type develops when the body's immune system destroys pancreatic islet cells that make the hormone insulin, which regulates blood-sugar levels. To control these levels, people with Type I diabetes must inject themselves daily with multiple insulin shots. Without these shots, many could die.

"Patients with Type I diabetes need a replacement of islet cells or whole pancreas transplants," says Jon Odorico, a UW-Madison Medical School transplant surgeon and senior author of the paper. But, he adds, "There's a huge shortage of cadaver donors - the main source for the transplants. A lot of people are looking for alternatives."

According to the latest study, embryonic stem cells - cells that have the ability to differentiate into, or form, any adult cell - could be one of them. "They could be a source for replacing the patient's own damaged islet cells," says the Wisconsin surgeon.

In the study, the researchers watched mouse embryonic stem cells differentiate into a variety of cells with specific functions. Of most interest to them were those cells involved in the formation of the pancreas, including its clusters of hormone-producing islet cells. The researchers found that the mouse stem cells, cultured in serum with no added growth factors, differentiated into pancreatic pre
'"/>

Contact: Jon Odorico
jon@tx.surgery.wisc.edu
608-265-6471
University of Wisconsin-Madison
28-Jul-2003


Page: 1 2 3

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. New fruitfly model of diabetes has future implications for pancreatic cell transplantation
3. Computer models expose humans as main cause of caribou decline
4. New model can aid in understanding immune system diseases
5. Physics gravity model applicable to disease spread
6. BioMed Central to consult funders and librarians over Open Access payment model
7. Study reveals surprising remodeling property of gene regulation process
8. Gene therapy reaches muscles throughout the body and reverses muscular dystrophy in animal model
9. Genetic model for devastating form of paraplegia suggests new treatments
10. New model explains why costly insect outbreaks hard to predict
11. A genetic model for hereditary spastic paraplegia (HSP) disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/7/2018)... ... , ... CTL Medical Corporation has entered into a definitive ... includes its complete portfolio of spine-related patents and 510ks, as well as any ... will make CTL Medical the world’s exclusive provider of silicon nitride spine products ...
(Date:8/31/2018)... , ... August 30, 2018 , ... ... scientist, IBM Research. Jacklyn Novak, infrared materials engineer, LightPath Technologies. In the future, ... mathematician who just celebrated her 100th birthday. Today, they are among 26 scientists ...
(Date:8/29/2018)... ... August 29, 2018 , ... ... first non-invasive technology to identify specific chromosomal abnormalities using morphological assessment through ... Fertility and Australia-based Life Whisperer suggests that artificial intelligence ...
Breaking Biology News(10 mins):
(Date:8/29/2018)... ... August 28, 2018 , ... Inc. ... lenses, has been ranked in 1138th place on the 27th annual Inc. 5000, ... The list represents the most successful companies within the American economy’s most dynamic ...
(Date:8/29/2018)... ... August 28, 2018 , ... USDM Life Sciences , ... sciences and healthcare industries, announces that Manu Vohra will deliver a presentation at the ... “How to Implement Box for GxP in 30 Days” , When: Thursday, August ...
(Date:8/23/2018)... ... August 22, 2018 , ... Crucial Data Solutions, ... making it the first fully-featured app for electronic data capture (EDC) and electronic ... Android constitute 99 percent of the market share for mobile devices worldwide; in ...
(Date:8/21/2018)... ... ... The Connecticut Technology Council (CTC) and Marcum LLP today announce the 2018 ... Connecticut. This year’s group of top-ranked companies will be honored at the new ConnectiTECH ... in Hartford. A complete list of the Marcum Tech Top 40 is included below. ...
Breaking Biology Technology:
Cached News: