ES cell model could provide clues to causes, cures for diabetes

cursor cells and islet cells producing four types of hormones, including insulin and glucagon.

But the study goes beyond confirming the ability of embryonic stem cells to form cells critical to regulating the body's blood sugar. The researchers say it offers a much-needed model for studying normal pancreatic development.

"In the process of identifying differentiated cell types, we carefully characterized the stages of their development," says Odorico. "These stages appear to recapitulate many aspects of normal development." In other words, islet and pancreatic precursor cells that were differentiated from embryonic stem cells in vitro, or outside the body, developed in ways similar to those differentiated in vivo, or inside the body.

For example, the cultured cells, just like those in the body, began to show features of early embryonic pancreas cells, such as the expression of specialized early transcription factors important for the formation of the pancreas. They also showed similar patterns of islet hormones, expressed genes that help regulate islet cells and ultimately generated insulin-producing cells.

"If human embryonic stem cells can be shown to differentiate to islets in this way with this culture system, then we can use this system to compare mouse and human pancreas developmental pathways for the first time," explains Odorico. Because access to fetal pancreatic material is limited, he adds, "most of what we think we know about human pancreatic development is merely extrapolated from mouse studies."

This model based on mouse embryonic stem cells that identifies their differentiation into pancreatic precursor cells and islet cell types, says Odorico, "should provide a valuable tool to study normal islet and pancreatic development. One could potentially use this model to identify novel genes and learn how islets form."

From all this, he adds, researchers could gain better insight into the causes of pancreas-

Contact: Jon Odorico
University of Wisconsin-Madison

Page: 1 2 3

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. New fruitfly model of diabetes has future implications for pancreatic cell transplantation
3. Computer models expose humans as main cause of caribou decline
4. New model can aid in understanding immune system diseases
5. Physics gravity model applicable to disease spread
6. BioMed Central to consult funders and librarians over Open Access payment model
7. Study reveals surprising remodeling property of gene regulation process
8. Gene therapy reaches muscles throughout the body and reverses muscular dystrophy in animal model
9. Genetic model for devastating form of paraplegia suggests new treatments
10. New model explains why costly insect outbreaks hard to predict
11. A genetic model for hereditary spastic paraplegia (HSP) disease

Post Your Comments:

(Date:4/4/2019)... ... 2019 , ... Orbsen Therapeutics, a biotechnology company focused on ... move its base of operations from the National University of Ireland (NUI) Galway ... in Galway, Ireland. , “With four clinical trials in full swing and the ...
(Date:4/4/2019)... ... April 02, 2019 , ... Researchers from Ambry Genetics ... RNA genetic testing (RGT), as a supplement to DNA genetic testing, improves variant ... poster, is one of 13 presentations at the 2019 American College of Medical ...
(Date:4/1/2019)... ... 2019 , ... uBiome announces the issue of patent number ... Patent and Trademark Office on January 1, 2019 with a priority date of ... Zachary Apte, Dr. Daniel Almonacid, Dr. Jessica Richman, and Dr. Catalina Valdivia, and ...
Breaking Biology News(10 mins):
(Date:3/27/2019)... ... March 27, 2019 , ... In honor of National Nutrition Month, Lajollacooks4u ... of healthy meals and good nutrition. This month, Chef Jodi Abel appeared on ... , The first segment addressed the nutritional value of USDA’s MyPlate, a ...
(Date:3/23/2019)... ... March 22, 2019 , ... uBiome has ... a team of researchers at Nnamdi Azikiwe University in Anambra State, Nigeria led ... PhD, of the Department of Medical Laboratory Sciences and Deputy Provost, College of ...
(Date:3/19/2019)... N.J. (PRWEB) , ... March 19, 2019 , ... The ... is a great opportunity to see the most cutting-edge cancer research. The Visikol team ... with 3D cell culture assays as well as their digital pathology ...
(Date:3/19/2019)... ... March 19, 2019 , ... Bogey was nine years old when he injured both ... left hip. These ailments caused Bogey to experience problems with his mobility. According ... and onto his special spot on the couch. , His owners, devastated at the sight ...
Breaking Biology Technology:
Cached News: