HOME >> BIOLOGY >> NEWS
Early dexamethasone exposure has long-term neurodevelopment, neuroendocrine effects

(June 28, 2004) -- Bethesda, MD -- Any parent of a newborn with extremely low birth weight (ELBW) faces the possibility that their child will be diagnosed with severe respiratory distress syndrome, which results in ventilator and/or oxygen dependency, and subsequent onset of chronic lung disease. Until recently, early administration of a prolonged course of postnatal dexamethasone was recommended to decrease the pulmonary inflammatory process during the early neonatal period. This approach changed, however, following a Taiwanese study that demonstrated a significant increase in neurodevelopmental dysfunction in neonates treated with dexamethasone.

Background

The Taiwanese conclusions were reached within the context that the window of exposure to dexamethasone in critically ill ELBW infants spans an extensive period of perinatal viability, ranging from 24 to 40 weeks post-conception. It is during this time that the human brain undergoes significant structural and functional transformations, thereby making it particularly vulnerable to external influences.

Clinical studies examining acute dexamethasone effects on physiology and central nervous system function in premature infants have been limited.

Past research into premature infants who received prolonged dexamethasone therapy experience reduced linear growth, decreased weight gain, and smaller head circumferences. During the acute phase of dexamethasone exposure, changes in gross neuromotor function have also been noted. As a result, use of dexamethasone to improve pulmonary function in ventilator-dependent ELBW infants is undergoing significant modification towards more judicious treatment dexamethasone therapy is given less often and shorter courses are now used.

The concern remains that little is known about dexamethasone effects on long-term neurodevelopment. For obvious reasons, human testing is not desired. Researchers have previously developed a rat mo
'"/>

Contact: Mayer Resnick
mresnick@the-aps.org
301-634-7209
American Physiological Society
29-Jun-2004


Page: 1 2 3 4

Related biology news :

1. Berkeley Lab soil scientist Margaret Torn receives Presidential Early Career Award
2. Early detection hope for eye disease
3. Early clinical treatment can halt progression of Alzheimers disease, UCI researchers find
4. Early predictor of breast cancer aggressiveness
5. Early treatment confirmed as key to stroke recovery
6. Early identification of kidney disease cost-effective only when directed at high-risk patients
7. Early promise for treatment of Ebola
8. Early treatment can prevent severe vision loss in premature infants
9. Early hominids may have behaved more human than we had thought
10. Early infection and rejection detection
11. Early-life environments shape development of stress behaviors and learning abilities in mice

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/5/2018)... ... October 04, 2018 , ... ... Extension and Monroe County Economic Development Corporation (EDC), has been awarded $680,000 ... and Agriculture (NIFA) Non-Land Grant College of Agriculture (NLGCA) Capacity-Building grants program. ...
(Date:10/5/2018)... ... October 04, 2018 , ... High dose of biotin may cause ... such as cardiac troponin has serious clinical complications. There is an increasing trend of ... still unknown. , High dose of biotin supplement use may continue to increase ...
(Date:10/3/2018)... NEW YORK (PRWEB) , ... October 03, 2018 ... ... based in New York City, announces the appointment of healthcare visionary, Jimmy Lee, ... innovative leader with over 30 years of healthcare industry experience. As a Senior ...
Breaking Biology News(10 mins):
(Date:10/16/2018)... FRANCISCO (PRWEB) , ... October 16, 2018 , ... ... of Dr. Isabel Moreno-Indias, PhD, Senior Researcher at the Biomedical Research Institute ... in the Physiopathology Network of Obesity and Nutrition, to its Scientific Advisory Board. ...
(Date:10/13/2018)... Fla. (PRWEB) , ... October 12, 2018 , ... ... professional not-for-profit society for laser education, innovation and commercialization, celebrates its 50th birthday ... Congress on Applications of Lasers and Electro-Optics (ICALEO) conference. , In celebration ...
(Date:10/5/2018)... ... October 04, 2018 , ... Power ... a Spine Technology Award from Orthopedics This Week during the 2018 National Association ... T Handle is a surgical instrument that delivers operating room efficiencies through increased ...
(Date:10/3/2018)... ... 03, 2018 , ... Milwaukee Area Technical College (MATC), a public, two-year comprehensive ... p.m. in Room T129 in the T Building, 101 N. 6th St., to introduce ... ribbon cutting and formal program will be held at 4 p.m. , MATC recently ...
Breaking Biology Technology:
Cached News: