HOME >> BIOLOGY >> NEWS
Early dexamethasone exposure has long-term neurodevelopment, neuroendocrine effects

(June 28, 2004) -- Bethesda, MD -- Any parent of a newborn with extremely low birth weight (ELBW) faces the possibility that their child will be diagnosed with severe respiratory distress syndrome, which results in ventilator and/or oxygen dependency, and subsequent onset of chronic lung disease. Until recently, early administration of a prolonged course of postnatal dexamethasone was recommended to decrease the pulmonary inflammatory process during the early neonatal period. This approach changed, however, following a Taiwanese study that demonstrated a significant increase in neurodevelopmental dysfunction in neonates treated with dexamethasone.

Background

The Taiwanese conclusions were reached within the context that the window of exposure to dexamethasone in critically ill ELBW infants spans an extensive period of perinatal viability, ranging from 24 to 40 weeks post-conception. It is during this time that the human brain undergoes significant structural and functional transformations, thereby making it particularly vulnerable to external influences.

Clinical studies examining acute dexamethasone effects on physiology and central nervous system function in premature infants have been limited.

Past research into premature infants who received prolonged dexamethasone therapy experience reduced linear growth, decreased weight gain, and smaller head circumferences. During the acute phase of dexamethasone exposure, changes in gross neuromotor function have also been noted. As a result, use of dexamethasone to improve pulmonary function in ventilator-dependent ELBW infants is undergoing significant modification towards more judicious treatment dexamethasone therapy is given less often and shorter courses are now used.

The concern remains that little is known about dexamethasone effects on long-term neurodevelopment. For obvious reasons, human testing is not desired. Researchers have previously developed a rat mo
'"/>

Contact: Mayer Resnick
mresnick@the-aps.org
301-634-7209
American Physiological Society
29-Jun-2004


Page: 1 2 3 4

Related biology news :

1. Berkeley Lab soil scientist Margaret Torn receives Presidential Early Career Award
2. Early detection hope for eye disease
3. Early clinical treatment can halt progression of Alzheimers disease, UCI researchers find
4. Early predictor of breast cancer aggressiveness
5. Early treatment confirmed as key to stroke recovery
6. Early identification of kidney disease cost-effective only when directed at high-risk patients
7. Early promise for treatment of Ebola
8. Early treatment can prevent severe vision loss in premature infants
9. Early hominids may have behaved more human than we had thought
10. Early infection and rejection detection
11. Early-life environments shape development of stress behaviors and learning abilities in mice

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/25/2019)... , ... April 24, 2019 , ... ... announces today the award of U.S. patent 10,191,929, “Systems and Methods for SNP ... and more efficient to conduct a variety of advanced bioinformatic analyses, including SNP ...
(Date:4/18/2019)... and WALNUT CREEK, Calif. (PRWEB) , ... April ... ... management solution for the healthcare industry, today announced the launch of mSource® AI ... processing to extract deep knowledge of Medpricer customers’ supplier contracts, truly optimizing purchased ...
(Date:4/16/2019)... ... April 16, 2019 , ... HealthLink International, experts ... its new medical device facility on Friday, April 12. Headquartered in the Netherlands, ... new facility includes 108,500 square feet and houses 32 employees enabling HealthLink to ...
Breaking Biology News(10 mins):
(Date:4/25/2019)... , ... April 24, 2019 , ... ... Agents for sales and service organizations, today announced global availability of Inference ... providers and enterprises of all sizes to harness the power of Google’s ...
(Date:4/15/2019)... ... April 15, 2019 , ... ... of a $2 million bench plant expansion to increase production of methylene malonate ... the design and construction of Sirrus’ full-scale production facility, which is scheduled to ...
(Date:4/9/2019)... , ... April 09, 2019 , ... ... focused on increasing the capacity of life sciences organizations to accelerate innovation and ... Assurance platform in the past 12 months. , USDM’s Cloud Assurance ...
(Date:4/8/2019)... ... April 08, 2019 , ... US Capital Global ... $15 million preferred equity investment in the privately held pharmaceutical company, S1 Biopharma (“S1”). ... Lorexys, is targeted at female hypoactive sexual dysfunction disorder and is ready to begin ...
Breaking Biology Technology:
Cached News: