HOME >> BIOLOGY >> NEWS
Ears can't hear when special sensory cells don't stay 'quiet'

(LOS ANGELES--May 1, 2003) Researchers may have found a link between progressive hearing loss and a gene called p19Ink4d (Ink4d), according to results of a study that measured loss of hearing in mice lacking that gene. Normally, the Ink4d gene keeps healthy cells "quiet" from inappropriately dividing.

Mice lacking the Ink4d gene become progressively hearing impaired because the absence of Ink4d causes certain cells in their inner ears to attempt to divide. However, this inappropriate attempt to divide causes these cells, called sensory hair cells, to instead commit suicide, according to a team of researchers that includes two St. Jude investigators and scientists from the House Ear Institute in Los Angeles, CA.

This finding in mice represents a potentially unrecognized form of progressive hearing loss, a problem that also occurs in humans, according to the investigators. If problems in Ink4d also occur in humans, this finding could explain the slow development of deafness in some people. In the absence of the braking effect of normally functioning Ink4d genes, sensory hair cells in people's ears might attempt to divide, setting off a biological response called apoptosis, or programmed cell death.

This observation in mice suggests that a person who lacks one or both copies of Ink4d, or who has Ink4d genes that are not very active, might suffer progressive hair cell death and experience hearing loss, just as mice do, according to Neil Segil, Ph.D., a researcher at the House Ear Institute and a research associate professor at the University of Southern California Medical School (Los Angeles). Segil, a senior author of a paper reporting these results, published in the May 2003 issue of Nature Cell Biology, speculates that the lack of one or both Ink4d genes makes the person more susceptible to hair cell loss from a variety of different traumas, such as loud noise or certain medicines. According to this theory, trauma could stimulate hair cel
'"/>

Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
1-May-2003


Page: 1 2 3 4

Related biology news :

1. Assisted reproduction cant compensate for waiting too long to start a family
2. When blood cant get to brain, special CT scan helps
3. Mutant biological machine makes proteins but cant let go
4. Marine reserves cant do it all: Sea otters vs. red abalone
5. Bacteria cant do their thing if they dont have cling
6. Targeting enzymes that immortalize cancer cells: if you cant turn them off, round them up
7. The bodys production of melatonin may be the reason why the elderly cant get a good nights sleep
8. Why some people just cant seem to pay attention
9. Researchers find clues about how antibodies specialize
10. Reading hexametric rhyme supports cardiac synchronization, especially after a heart attack
11. Bigger isnt always better--especially if youre a rodent

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2016)... LONDON , April 26, 2016 ... a product subsidiary of Infosys (NYSE: ... to integrate the Onegini mobile security platform with ... http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The integration will ... to access and transact across channels. Using this ...
(Date:4/15/2016)... CHICAGO , April 15, 2016  A ... companies make more accurate underwriting decisions in a ... offering timely, competitively priced and high-value life insurance ... health screenings. With Force Diagnostics, rapid ... and lifestyle data readings (blood pressure, weight, pulse, ...
(Date:4/13/2016)... 2016  IMPOWER physicians supporting Medicaid patients in ... clinical standard in telehealth thanks to a new partnership ... platform, IMPOWER patients can routinely track key health measurements, ... index, and, when they opt in, share them with ... a local retail location at no cost. By leveraging ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016  Sequenom, Inc. (NASDAQ: SQNM ... lives through the development of innovative products and services, ... the United States denied its petition to ... of Sequenom,s U.S. Patent No. 6,258,540 (",540 Patent") are ... by the Supreme Court,s Mayo Collaborative Services v. Prometheus ...
(Date:6/27/2016)... ... June 27, 2016 , ... Newly created ... services and solutions to the healthcare market. The company's primary focus is on ... sales and marketing strategies that are necessary to help companies efficiently bring their ...
(Date:6/27/2016)... June 27, 2016   Ginkgo Bioworks , a ... engineering, was today awarded as one of the ... the world,s most innovative companies. Ginkgo Bioworks is ... the real world in the nutrition, health and ... directly with customers including Fortune 500 companies to ...
(Date:6/24/2016)... ... ... While the majority of commercial spectrophotometers and fluorometers use the z-dimension of 8.5 ... end machines that use the more unconventional z-dimension of 20mm. Z-dimension or ... the cuvette holder. , FireflySci has developed several Agilent flow cell product lines ...
Breaking Biology Technology:
Cached News: