HOME >> BIOLOGY >> NEWS
Easily paralyzed flies provide clues to neurodegeneration

of the pharmaceutical industry. For instance, in the United States all drugs now headed to market must be screened to ensure that they do not perturb the function of Herg channels and possibly cause heart problems in patients. The tendency to affect such channels was the reason that Seldane, a popular asthma medication, was pulled from the market.

Adding to the mutant flies' cachet, recent work by Ganetzky and post-doctoral fellow Michael Palladino showed that some of the mutants in their collection undergo progressive, age-dependent neurodegeneration resulting in the widespread death of brain cells.

"The neuropathology observed in these mutants is very reminiscent of that in human disorders such as Alzheimer's disease and Parkinson's disease," says Ganetzky. "Such disorders are a growing human health concern, but the underlying cellular mechanisms are still poorly understood. These mutants should provide us with valuable new insights into the molecular basis of neurodegeneration in both flies and humans."

Ganetzky believes his collection of fly models, which has been licensed by the Wisconsin Alumni Research Foundation, could become a rich resource to help pharmaceutical companies identify new biological targets and develop new high-volume screens for drug development.

"I think the mutants have real value to give us novel information about neural disorders and human disease," Ganetzky asserts. "We can't even begin to guess what new insight might be lurking in these flies."


'"/>

Contact: Barry Ganetzky
ganetzky@wisc.edu
608-263-2404
University of Wisconsin-Madison
4-Dec-2003


Page: 1 2 3

Related biology news :

1. Human stem cells improve movement in paralyzed rats
2. Stem cells graft in spinal cord, restore movement in paralyzed mice
3. Length of sex act in flies dictated by genetics
4. How wounds heal Clues from flies
5. Study in flies allows researchers to visualize formation of a memory
6. Butterflies & the hormonal basis of interactions between life histories & morphology
7. Devastating parasitic weed may be felled by toxin borrowed from flies
8. Researchers model embryo implantation and tumour metastasis in fruit flies
9. Male flesh flies high-speed pursuit of females
10. ESA astronaut flies Cervantes mission to ISS
11. Genes that regulate hearing link humans and fruit flies in new way

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Easily paralyzed flies provide clues neurodegeneration

(Date:7/28/2014)... TEMPE, Ariz. - Reactions among minerals and organic compounds ... deep carbon cycle, they provide energy for the deep ... life. However, very little is known about how minerals ... Arizona State University have demonstrated how a common mineral ... negating the need for toxic solvents or expensive ...
(Date:7/28/2014)... Solanum pennellii , a wild relative of the domestic ... researchers including the labs headed by Professors Neelima Sinha ... Plant Biology. The new genome information may help breeders ... July 27 in the journal Nature Genetics , ... University in Germany. The UC Davis labs carried out ...
(Date:7/28/2014)... research has identified areas of the Earth that are ... change. , Europe is particularly vulnerable, as it has ... per cent, of any continent in ,refugia, areas ... environmental conditions remain relatively constant during times of great ... are mostly in Scandinavia and Scotland. , The ...
Breaking Biology News(10 mins):Mineral magic? Common mineral capable of making and breaking bonds 2Mineral magic? Common mineral capable of making and breaking bonds 3Study finds Europe's habitat and wildlife is vulnerable to climate change 2
(Date:7/29/2014)... (PRWEB) July 29, 2014 The first ... a next generation approach to robotics. What sets Droidles ... patent pending technology that allows them to communicate, share ... wirelessly over the internet. , “The invention is the ... the little Droidles a life of their own, both ...
(Date:7/29/2014)... Acres, FL (PRWEB) July 29, 2014 ... ex situ lift out specimen preparation solutions, has been ... Trademark Office for specimen manipulation methods incorporating a unique ... 8,740,209. This is the second company patent for ... A. Giannuzzi. , These complementary patents extend ...
(Date:7/28/2014)... July 28, 2014 “2014 ... Lubricant Industry” is a professional and in-depth ... market. The report introduces Lubricant basic information, ... chain structure and industry overview. This research ... domestic market as well as global industry ...
(Date:7/28/2014)... 28, 2014 According ... Market by Products (Consumables, Instruments, Services), Methods (Phenotypic, Genotypic), Applications (Pharmaceutical, ... (Detection, Characterization) - Global Forecasts to 2019" ... is estimated at $896.5 Million in 2014 ... by 2019, growing at a CAGR of ...
Breaking Biology Technology:Droidles, the Social Network of Robots and Open Source Platform for the Internet of Things, Launches for Crowd Funding on IndieGoGo.com 2EXpressLO LLC Granted Second U.S. Patent for Innovative Specimen Preparation Methods 2Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 2Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 3Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 4Microbial Identification Market worth $1,194.1 Million by 2019 2Microbial Identification Market worth $1,194.1 Million by 2019 3
Cached News: