HOME >> BIOLOGY >> NEWS
Easily paralyzed flies provide clues to neurodegeneration

of the pharmaceutical industry. For instance, in the United States all drugs now headed to market must be screened to ensure that they do not perturb the function of Herg channels and possibly cause heart problems in patients. The tendency to affect such channels was the reason that Seldane, a popular asthma medication, was pulled from the market.

Adding to the mutant flies' cachet, recent work by Ganetzky and post-doctoral fellow Michael Palladino showed that some of the mutants in their collection undergo progressive, age-dependent neurodegeneration resulting in the widespread death of brain cells.

"The neuropathology observed in these mutants is very reminiscent of that in human disorders such as Alzheimer's disease and Parkinson's disease," says Ganetzky. "Such disorders are a growing human health concern, but the underlying cellular mechanisms are still poorly understood. These mutants should provide us with valuable new insights into the molecular basis of neurodegeneration in both flies and humans."

Ganetzky believes his collection of fly models, which has been licensed by the Wisconsin Alumni Research Foundation, could become a rich resource to help pharmaceutical companies identify new biological targets and develop new high-volume screens for drug development.

"I think the mutants have real value to give us novel information about neural disorders and human disease," Ganetzky asserts. "We can't even begin to guess what new insight might be lurking in these flies."


'"/>

Contact: Barry Ganetzky
ganetzky@wisc.edu
608-263-2404
University of Wisconsin-Madison
4-Dec-2003


Page: 1 2 3

Related biology news :

1. Human stem cells improve movement in paralyzed rats
2. Stem cells graft in spinal cord, restore movement in paralyzed mice
3. Length of sex act in flies dictated by genetics
4. How wounds heal Clues from flies
5. Study in flies allows researchers to visualize formation of a memory
6. Butterflies & the hormonal basis of interactions between life histories & morphology
7. Devastating parasitic weed may be felled by toxin borrowed from flies
8. Researchers model embryo implantation and tumour metastasis in fruit flies
9. Male flesh flies high-speed pursuit of females
10. ESA astronaut flies Cervantes mission to ISS
11. Genes that regulate hearing link humans and fruit flies in new way

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Easily paralyzed flies provide clues neurodegeneration

(Date:3/20/2015)... , March 20, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, ... is one of the products featured in 2015 "I ... at 11:00 PM EST on the DIY Network.   ... Las Vegas , site of the 2015 ...
(Date:3/17/2015)... 17, 2015 Emotient, the leader in ... announced general availability of Emotient Analytics , ... analysis of facial expressions. The system analyzes videos ... products and services. It delivers audience response metrics ... - as derived from facial evidence of emotional ...
(Date:3/12/2015)... BERLIN , March 12, 2015 ... IAM, a standardized identity and access management (IAM) ... reliable implementation schedule. With Beta System,s new IAM ... and best practices gleaned from multiple IAM implementations ... includes the software as well as any necessary ...
Breaking Biology News(10 mins):NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 2New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 4Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2
(Date:3/26/2015)... 2015 PAREXEL International Corporation (Nasdaq: ... research organization , announced today that the ... acquire all of the business assets of privately-owned ... of specialized pharmacovigilance services, based in Chandigarh, ... assessment, monitoring, and prevention of adverse effects ...
(Date:3/26/2015)... March 26, 2015 Ale Gicqueau, Founder ... Director of Clinical Affairs at Align Technology, on “ ... the upcoming ACRP 2015 Global Conference and Exhibition on ... Utah. , During the poster presentation, Ale Gicqueau ... and running a Postmarket Registry, the requirements and resources ...
(Date:3/25/2015)... March 26, 2015 Agnition announced today ... of American Farmer, airing for the first time at ... of American Farmer will explore the extremely important role ... producers with a patented Microbial Catalyst™ technology that enhances ... yields. The segment will air again on April 28. ...
(Date:3/25/2015)... UK (PRWEB) March 25, 2015 ... uptake of smartphones have fuelled social media growth, ... being currently engaged in social networking. Insurance companies ... to communicate with clients and promote a diversity ... globe over are increasingly exploiting social networking services ...
Breaking Biology Technology:PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 4Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 2Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 3Agnition to be Featured In Upcoming Episode of American Farmer on RFD-TV 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 3
Cached News: