HOME >> BIOLOGY >> NEWS
East meets West: A new memory enhancing drug based on chinese herbal medicine

Blacksburg, Va., August 22, 2000 -- Huperzine A, a compound isolated from the Chinese Medicinal Herb "Qian Ceng Ta," has shown good efficacy in improving the memory in patients suffering from Alzheimer's Disease. Despite these promising results, Huperzine A has not been developed as a drug in the West due to scarcity of the natural source, a complicated molecular structure, and the lack of intellectual property protection for this material. Virginia Tech researcher Paul R. Carlier, an associate professor of chemistry, has come up with a novel solution to these problems.

Carlier will present his research at the 220th national meeting of the American Chemical Society Aug. 20-24 in Washington, D.C.

Working in collaboration with researchers at the Hong Kong University of Science and Technology (HKUST) and the Mayo Clinic, Carlier found that a highly simplified fragment of the Huperzine A molecule could be easily synthesized from cheap, commercially available chemicals. In isolation this fragment is ineffective as a memory enhancer. However, based on a detailed analysis of acetylcholinesterase, the brain enzyme with which Huperzine A interacts, Carlier prepared dimeric analogs by joining two of these fragments with a molecular tether.

"Remarkably, the optimum drug obtained by this approach, ('Huperzine A Fragment Dimer') is more than twice as potent as Huperzine A itself," he reports. "The enhanced potency observed is due to two-point attachment of the dimeric drug to acetylcholinesterase," he says.

Carlier stresses that all of the tests have been in animals, including a behavioral assay in rats that establishes improved memory.

"No work has been done in humans; and, even if the compounds prove effective in human, it will be as a treatment of the memory loss in the early stages of the disease," he says. "This approach could never cure Alzheimer's; and, after the disease progresses to a certain point, these drugs could not restore mental functio
'"/>

Contact: Paul Carlier
540-231-9219
Virginia Tech
22-Aug-2000


Page: 1 2

Related biology news :

1. Chemistry meets Biology
2. The American Society for Biochemistry and Molecular Biology meets in Boston
3. Experimental Biology 2004 meets in Washington, D.C. April 17-21
4. Experimental Biology 2003 meets in San Diego April 11-15
5. Experimental Biology 2003 meets in San Diego April 11-15
6. American Chemical Society meets August 26-30 in Chicago
7. When Shewanella meets goethite: Evidence found of recognition between animate and inanimate objects
8. FDA clears Berlex Laboratories Mirena (R), new form of long-acting contraception meets need for U.S. women
9. From Germany To The Wild West: Geologists Hunt For Evidence Of Ancient Crinoid
10. Brown research reveals key insight into memory-making
11. Wrapping a memory with an experience, capacity for recollection detected in non-human species

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... CHURCH, Va. (PRWEB) , ... July 08, 2020 ... ... The Latest on Cell and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July ... may need a comparability study, but what is the most effective way to ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... B.V. (MBS) has announced a publication detailing the use of its revolutionary ... polymerase chain reaction (RT-PCR) in 16 minutes. The article, titled "Ultra-fast one-step ...
(Date:6/28/2020)... ... 2020 , ... In an upcoming episode scheduled for the fall of 2020, ... solutions (POCT). Check local listings for more info. , Today, the majority of testing ... to labs throughout the country. Results are then available several days later. Now, in ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... ... 2020 , ... True Terpenes , the leading platform for terpene innovation, ... to research the medical potential of terpenes and the potential entourage effect , ... board is focused on expanding the recently launched line of effects-based terpenes - ...
(Date:8/7/2020)... Texas (PRWEB) , ... August 06, 2020 , ... ... and DNA vaccine industries, announces it has closed on the purchase of greenfield ... Park in Conroe, TX and includes over 21 acres in the initial acquisition, ...
(Date:7/31/2020)... , ... July 29, 2020 , ... ... solid-state radar transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, ... that can drive one or two switches in a push-pull configuration; yielding fast ...
(Date:7/31/2020)... FRANCISCO (PRWEB) , ... July ... ... provider of cloud-based software for the life sciences industry, today announced the ... presentation platform designed specifically for Medical Science Liaisons (MSLs) and other field ...
Breaking Biology Technology:
Cached News: