Effect of "High-Dose" SWL (8000 Shocks at 24kV) to One Renal Pole on Bilateral Hemodynamics and Tubular Function

Lithotripsy is used to break up kidney stones and upper urethral stones into tiny fragments so they can be secreted in the urine. However, a clinical dose of shock wave lithotripsy (SWL) to one kidney can damage tissue, impair renal blood flow, and temporarily reduce the tubular function of the kidney. These investigators wanted to test the hypothesis that a high "dose" of shock waves (8000 shocks at 24 kilovolts) to one kidney would cause great, sustained impairment of hemodynamics in both kidneys. Consequently, they used sham lithotripsy, 2000 shocks, or 8000 shocks to the right kidney of six-week-old anesthetized pigs. The found that a large number of shocks applied to one pole of a kidney caused similar, large, and sustained impairment of renal hemodynamics and large transient reduction of tubular function in both kidneys. They believe that their data suggests SWL-induced injury releases a substance that causes bilateral renal vasoconstriction and impairs renal tubular secretion.


Contact: Bill Glitz
American Urological Association

Page: 1

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