In 1984, HARBOR BRANCH scientists exploring deep waters off the Bahamas in one of the institution's Johnson-Sea-Link submersibles discovered a small piece of sponge that harbored a chemical with a remarkable ability to kill cancer cells in laboratory tests. Despite almost two decades of searching, though, the group was never able to find enough of the sponge to fully explore its potential. But now that process can finally begin because, thanks to some creative detective work, the team has found the animal's secret hiding place and collected enough of it to support years of intense research.

"It's just amazing," says Amy Wright, director of HARBOR BRANCH Biomedical Marine Research, of the sponge she has been on a career-long quest to find. "This is our next cure, I know it's our next cure."

A chemical produced within the sponge, which has not yet been given an official name, has proven in one test of cancer-fighting potential to be about 400 times more potent than Taxol, a widely used treatment for breast and other forms of cancer. As important, preliminary experiments have also shown the compound to be fairly non-toxic to normal cells.

But the limited amount of the sponge initially collected was not enough to carry the team through the long process of developing a potential medical treatment, which involves careful study of exactly how a chemical kills cancer cells and of its chemical structure. "Since 1984 it has been on our target list for every dive," says Wright, who first studied the compound as a postdoctoral fellow at HARBOR BRANCH during the '80s.

On various expeditions over the years, scientists found only tiny pieces of the sponge, then last year two slightly larger pieces, but still they did not have enough to do the required research. So, in preparation for a cruise this year to the Bahamas that ran from Oct. 9 through the 24th, Wright and her team used clues from where each piece had been collected to put togethe
'"/>

Contact: Mark Schrope
schrope@hboi.edu
772-216-0390
Harbor Branch Oceanographic Institution
27-Oct-2003

Page: 1 2 3
Related biology news :

1. Elusive but ubiquitous microbe fingered as gum disease culprit in Stanford study
2. Studies At Cedars-Sinai Confirm Identity Of An Elusive Receptor In Human Cells -- A Breakthrough In Understanding, Fighting Septic Shock
3. Wisconsin Scientists Culture Elusive Embryonic Stem Cells
4. Leader in cancer treatment and prevention research honored
5. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
6. Chemical derived from vitamin-E shows early promise as cancer drug
7. New molecular link key to cellular proteins involved in cancer progression, other diseases
8. Phase II trials of second-generation antisense cancer drug planned following successful early study
9. Trial shows which brain cancer patients benefit from temozolomide
10. Genetic differences might help distinguish thyroid cancers
11. Evidence builds for potential new cancer drug target