Embryonic mouse stem cells reduce symptoms in model for Parkinson's disease

Embryonic mouse stem cells transformed into neurons in a lab dish and then transplanted into a rat model for Parkinson's disease (PD) form functional connections and reduce disease symptoms, a new study shows. The finding suggests that embryonic stem (ES) cells may ultimately be useful for treating PD and other brain diseases.

The study is one of the first to show that ES cells can develop into neurons that function in the brain, according to senior author Ronald McKay, Ph.D., of the National Institute of Neurological Disorders and Stroke (NINDS). The report appears in the June 23, 2002, advance online publication of Nature.* A second study in Nature,** led by Catherine Verfaillie, M.D., at the University of Minnesota in Minneapolis, shows that bone marrow-derived cells called mesenchymal stem cells have many of the characteristics of ES cells.

Dr. McKay and his colleagues added a gene called Nurr1 to cultured mouse ES cells and exposed them to a series of growth factors that caused them to develop into neurons. Nurr1 helps neural precursor cells differentiate, or change, into neurons that produce the neurotransmitter dopamine. The loss of dopamine-producing neurons is a central feature of PD. To see if the ES cell-derived neurons would survive and function in animals, the researchers transplanted the neurons into rats that were missing the dopamine-producing cells on one side of their brains.

These rats have parkinsonian symptoms on one side of their bodies. A similar group of rats received transplants of ES cells without the Nurr1 gene, and a third group received sham operations.

The researchers found that the grafted cells established functional connections with surrounding brain cells and began to release dopamine. The rats that received the Nurr1-positive cells showed significant improvements in symptoms during several behavioral tests. Rats that received cells without the Nurr1 gene showed some improvement in parkinsoni

Contact: Natalie Frazin or Paul Girolami
NIH/National Institute of Neurological Disorders and Stroke

Page: 1 2 3

Related biology news :

1. Embryonic stem cell therapy shows steady benefits in rebuilding infarcted heart
2. Embryonic stem cell - based tissue engineering may help repair damaged heart muscle
3. Embryonic skin cells committed at an early age
4. Embryonic pig cell transplants halt rat diabetes
5. Embryonic pathway critical to growth of digestive tract tumors
6. Embryonic hope for damaged spines
7. Embryonic facial development subject to insult or repair longer than expected
8. Statement Of The DFG Concerning "Questions Of Human Embryonic Stem Cells"
9. Molecular Control Mechanism Of Embryonic Development Unraveled
10. First Derivation Of Human Embryonic Stem Cells Reported In Science
11. Hopkins Research Team Cultures Long-Awaited Human Embryonic Stem Cells

Post Your Comments:

(Date:6/28/2020)... (PRWEB) , ... June 25, 2020 , ... In an ... on innovations in accelerated Point of Care Testing solutions (POCT). Check local listings for ... are collected at medical offices and are shipped to labs throughout the country. Results ...
(Date:6/23/2020)... MILTON KEYNES, England (PRWEB) , ... June 23, ... ... operations in Africa supporting sustainable healthcare, and Renovagen Ltd, a UK supplier and ... rapid response project to support testing operations in the fight against the COVID-19 ...
(Date:6/23/2020)... ... 23, 2020 , ... In its June 22 online post, business and technology ... Sherley, M.D., Ph.D., founder and director of stem cell biotechnology company Asymmetrex . ... that starting July 5 it would begin offering free tissue stem cell ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... (PRWEB) , ... June 23, 2020 , ... ... solutions in complex indoor environments, announced today that Derek Fournier has been appointed ... of Chairman of the Board, effective immediately. , “DeCurtis Corporation has been ...
(Date:6/23/2020)... ... June 22, 2020 , ... Dracen ... will be presented June 22-24 during the American Association for Cancer Research Virtual ... other profiles the potent, consistent single agent activity in KEAP1 mutant tumor models ...
(Date:6/19/2020)... ... June 18, 2020 , ... The Vitaspace project was ... join forces to radically prolong life and find a way (medicine or technology) that ... project was supported by various scientists from all over the world, doctors, and all ...
(Date:6/11/2020)... , ... June 09, 2020 , ... ... Phase I of a Small Business Innovation Research (SBIR) program funded by the ... Century: Rapid Toxin Detection in the Field”. The project’s goal was to engineer ...
Breaking Biology Technology:
Cached News: