Embryonic stem cell - based tissue engineering may help repair damaged heart muscle

NEW YORK--Embryonic stem cells may hold the key to regenerating damaged heart muscle, when transplanted within a 3-dimensional scaffold into the infracted heart, according to a new study coming out in June in the Journal of Heart and Lung Transplantation. In the study, embryonic stem cells were more successful in restoring heart muscle when transplanted within a 3-dimensional matrix into damaged hearts in an animal model of severe infarction.

The new study addresses several problems that have plagued previous attempts to regenerate damaged heart muscle, according to Theo Kofidis, M.D., who has an active tissue engineering program at Stanford.

"Tissue engineering holds out promise of truly healing the heart after congestive heart failure," said Dr. Kofidis, lead author of the study and research fellow in cardiothoracic surgery at the Falk Research Center at Stanford University Medical School in Stanford, Calif. "There are 460,000 cases of congestive heart failure in the United States each year and the preeminently efficient treatment we have at this time is heart transplantation. Through tissue engineering we could actually restore the function of the heart by replacing large portions of the damaged heart muscle by a bioartificial one."

Dr. Kofidis spoke today at an American Medical Association media briefing on cardiology in New York City.

Kofidis and his colleagues had been working with bone marrow stem cells, but these cells were not able to become heart muscle cells and regenerate the heart. "In our most recent studies we showed that mouse and human embryonic stem cells improved heart function, had superior survival within the heart weeks later we still saw improved heart function and had definitely differentiated into heart muscle cells," he said. "We inserted a bioluminescent marker (what causes fireflies to luminesce) into our stem cells and were able to see that they engrafted in the living organ."

There a

Contact: Amy Adams
American Medical Association

Page: 1 2

Related biology news :

1. Embryonic stem cell therapy shows steady benefits in rebuilding infarcted heart
2. Embryonic skin cells committed at an early age
3. Embryonic pig cell transplants halt rat diabetes
4. Embryonic pathway critical to growth of digestive tract tumors
5. Embryonic hope for damaged spines
6. Embryonic facial development subject to insult or repair longer than expected
7. Embryonic mouse stem cells reduce symptoms in model for Parkinsons disease
8. Statement Of The DFG Concerning "Questions Of Human Embryonic Stem Cells"
9. Molecular Control Mechanism Of Embryonic Development Unraveled
10. First Derivation Of Human Embryonic Stem Cells Reported In Science
11. Hopkins Research Team Cultures Long-Awaited Human Embryonic Stem Cells

Post Your Comments:

(Date:8/21/2020)... ... August 19, 2020 , ... “How ... LLC, businesses dedicated to Salivary Bioscience for more than twenty years. Together with ... by Springer, " Salivary Bioscience: Foundations of Interdisciplinary Saliva Research and Applications ," ...
(Date:8/12/2020)... ... August 12, 2020 , ... Mosio recently announced its ... public health agencies of all sizes. With a focus on tracking symptoms and ... appropriate health care, Mosio helps public health departments automate communications and provide more ...
(Date:8/3/2020)... ... 2020 , ... Accumen Inc. is helping healthcare get better, ... Solutions, to provide COVID-19 saliva testing kits nationally. , “Accumen has been ... 10 years. Early in the COVID-19 crisis, we identified supply chain gaps and ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... , ... July 29, 2020 , ... ... announced the launch of its new tagline, “BUILDING FOR LIFE.” The adoption of ... and around the globe, requiring fast track capacity to provide patients with urgently ...
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been touted ... will cover the history of eSource, the reasons it did not take off as ... to site source, the industry is moving towards capturing data electronically for clinical trials ...
(Date:7/18/2020)... ... ... After research model surgery and catheter implantation, the long journey of catheter ... of a successful study, while protecting and accessing the catheter or device post-surgery is ... from Envigo in a live webinar on Wednesday, August 5, ...
(Date:7/10/2020)... ... July 08, 2020 , ... Bode Technology, a ... laboratory operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines high-volume ... Bode-CARES provides a turnkey solution that includes a comprehensive collection and virus-management ...
Breaking Biology Technology:
Cached News: