The team will seek clues to the mechanisms of the triple-repeat expansion and the suppression of FMRP during transcription as well as the role of FMRP on protein translation and the consequence of its absence on protein synthesis in neurons in specific regions of the brain and spine. They will develop model systems, including one to investigate yeast genes that express proteins similar to FMRP, and a new generation of FMR1 knockout mice in which they can closely control FMRP expression, both pre- and postnatally, through drug exposure. The investigators also will address fundamental questions relating to possible future therapeutic strategies.

Stephen T. Warren, Ph.D., is the only Howard Hughes Medical Institute (HHMI) Investigator in the State of Georgia. The HHMI, located in Chevy Chase, MD, was founded in 1953 by the aviator-industrialist, Howard R. Hughes. It is a scientific and philanthropic organization whose primary purpose is conducting biomedical research.

Currently there are more than 330 Howard Hughes Medical Institute investigators. Widely recognized for their creativity and productivity, they include several Nobel Prize winners and more than 50 members of the National Academy of Sciences. The scientists are employed by HHMI and conduct their work at HHMI facilities at leading research institutions nationwide under collaborative relationships with those institutions.

Through its Grants Program, HHMI supports the research of outstanding biomedical scientists in selected countries outside the United States. These International Research Scholars are located in nations as diverse as Mexico, Australia and the former Soviet Republics. In conjunction with the National Institutes of Health (NIH), the Institute maintains the Research Scholars Program, which provides research opportunities for selected medical students in the laboratories of NIH scientists.

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Contact: Holly Korschun
hkorsch@emory.edu
404/727-3990
Emory University Health Sciences Center
26-Jan-1998

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