Emory Vaccine Research Center study identifies specific gene required for long-term immunity

In a study in the Jan. 16 issue of Nature, scientists at the Emory Vaccine Research Center show that a gene called SAP is required to generate long-term immunity.

By measuring the immune responses of "knockout" mice genetically engineered to lack SAP, researchers found that the gene's absence impairs the immune system's "memory," namely its ability to recognize and react to infection. This finding has implications for research in vaccines, which by definition must engender long-term immunity.

SAP recently was identified as the gene responsible for a lethal human genetic disease, X-linked lymphoproliferative disease.

"There are only a few known lethal immunodeficiencies in humans, and a defect in the SAP gene is one of them," said first author Shane Crotty, Ph.D. "So this gene is clearly important for immune responses. Our work now shows that the SAP gene is a central player in long-term antibody responses, and indicates that manipulation of SAP may have therapeutic benefits in generating better antibody responses."

Crotty and his colleagues compared the immune responses of the knockout mice against those of genetically normal control mice. When infected with a virus, in this case lymphocytic choriomeningitis virus, both sets of mice mounted initial immune responses of similar magnitude. After the initial response subsided, however, the SAP-negative mice failed to produce significant numbers of either virus-specific plasma cells or memory B-cells, both of which are crucial components of long-term immunity.

In the Nature paper, the investigators commented that it is unusual to find that a gene affects long-term but not short-term immunity.

"What is so interesting about this gene is that it controls the generation of long-term memory, but it's not important for short-term immune responses. We haven't seen a gene that does this before," said Rafi Ahmed, Ph.D., VRC Director and senior author of the study.

The researchers were able

Contact: Holly Korschun
Emory University Health Sciences Center

Page: 1 2 3

Related biology news :

1. Emory researchers map structure of anti-cancer molecule
2. Hope Clinic of Emory Vaccine Center receives CDC contract
3. Emory scientists receive NIH MIDAS grant for computer modeling of infectious diseases
4. Emory researchers develop model to track the evolution of emerging infectious diseases
5. Emory scientists use enzymes to enhance regeneration of damaged peripheral nerves in mice
6. Emory scientists track down immune sentinel cells with gene gun
7. Emory researchers discover novel mechanism of how anthrax impairs immunity
8. Emory scientists find anti-tumor compounds in magnolia cones
9. Emorys CancerQuest wins top Web award from Scientific American
10. Emory University researchers uncover novel self-assembly of Alzheimers amyloid fibrils
11. Emory to receive more than $6.5 million to study environmental risk factors for Parkinsons disease

Post Your Comments:

(Date:2/5/2020)... (PRWEB) , ... February 05, 2020 , ... ... developed to bring greater ease, efficiency and insight to sample processing within laboratories. ... academic and biotech laboratories conducting research in various fields, LabKey Sample Manager has ...
(Date:1/30/2020)... ... January 30, 2020 , ... Accelera Canada , a ... the Canadian market, is pleased to announce that the company has opened the doors ... company launched in 2017. , “We are so thrilled to now have all ...
(Date:1/29/2020)... ... January 29, 2020 , ... INDIGO Biosciences, Inc. (INDIGO), ... has announced a record earnings year for 2019. With final numbers to be ... twenty percent increase in revenue and a thirty percent increase in gross profit, ...
Breaking Biology News(10 mins):
(Date:2/21/2020)... N.Y. (PRWEB) , ... February 20, 2020 , ... ... for ensuring supply chain transparency and reassuring consumers that what’s listed on an ... and trademarked ingredients, Nutrition21 has introduced this solution with the adoption of CertainT, ...
(Date:2/19/2020)... ... February 18, 2020 , ... ... populations down to the strain level, recently unveiled a novel DNA isolation product. ... and unbiased isolation of high molecular weight (HMW) single-stranded DNA (ssDNA) in excess ...
(Date:2/13/2020)... DUBLIN (PRWEB) , ... February 12, 2020 , ... ... affairs, and pharmacovigilance (PV) solutions and services, is adopting Veeva Vault Safety™ ... databases are a requirement for fast assessment of data, processing of safety information ...
(Date:2/10/2020)... , ... February 10, 2020 , ... R3 Medical Training ... March 13-14th, 2020 in Las Vegas. The course is hands on involving real ... For the past few years, the Comprehensive Stem Cell Training Course has received rave ...
Breaking Biology Technology:
Cached News: