HOME >> BIOLOGY >> NEWS
Emory researchers discover novel mechanism of how anthrax impairs immunity

ATLANTA In the first study of its kind, researchers led by Bali Pulendran, PhD, at the Emory Vaccine Center and the Yerkes National Primate Research Center have shown that anthrax lethal factor (LF) impairs the function of dendritic cells and thereby compromises the immune system's ability to fight the microbe. The findings, which appear in the July 17 issue of Nature, have implications for developing more effective anthrax therapies and guiding researchers in better controlling detrimental immune responses, such as in autoimmune diseases and organ rejection following transplant surgeries.

For his study, Dr. Pulendran, associate professor in the Department of Pathology and Laboratory Medicine at Emory University School of Medicine, and Anshu Agrawal, PhD, a post-doctoral fellow in his lab, in collaboration with Conrad Quinn, PhD, and Jai Lingappa, MD, at the Centers for Disease Control and Prevention, and Steve Leppla, PhD, at the National Institutes of Health, chose to study dendritic cells versus the previously studied macrophages. Dendritic cells are widely recognized as the most efficient antigen-presenting cells, making them pivotal in initiating and modulating any immune response against microbes.

"This is the first study that demonstrates any interaction between Bacillus anthracis and dendritic cells, " says Dr. Pulendran. "Our findings reveal a novel mechanism of action by which the microbe targets the host-immune reaction."

In the study, Dr. Pulendran's research team demonstrated that LF impairs dendritic cell function by disrupting the mitogen-activated protein (MAP) kinase enzymes within dendritic cells. Consequently, the dendritic cells become lethargic and unable to act normally, thereby preventing the activation of the immune system to attack microbes such as anthrax.

"When a person is infected with a microbe, we count on the immune system to begin fighting the foreign substance immediately," Dr. Pulendran commented. "When the d
'"/>

Contact: Lisa Newbern
lmnewbe@emory.edu
404-727-7709
Emory University Health Sciences Center
16-Jul-2003


Page: 1 2

Related biology news :

1. Emory researchers map structure of anti-cancer molecule
2. Hope Clinic of Emory Vaccine Center receives CDC contract
3. Emory scientists receive NIH MIDAS grant for computer modeling of infectious diseases
4. Emory researchers develop model to track the evolution of emerging infectious diseases
5. Emory scientists use enzymes to enhance regeneration of damaged peripheral nerves in mice
6. Emory scientists track down immune sentinel cells with gene gun
7. Emory scientists find anti-tumor compounds in magnolia cones
8. Emorys CancerQuest wins top Web award from Scientific American
9. Emory University researchers uncover novel self-assembly of Alzheimers amyloid fibrils
10. Emory Vaccine Research Center study identifies specific gene required for long-term immunity
11. Emory to receive more than $6.5 million to study environmental risk factors for Parkinsons disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: