HOME >> BIOLOGY >> NEWS
Emory researchers discover novel mechanism of how anthrax impairs immunity

ATLANTA In the first study of its kind, researchers led by Bali Pulendran, PhD, at the Emory Vaccine Center and the Yerkes National Primate Research Center have shown that anthrax lethal factor (LF) impairs the function of dendritic cells and thereby compromises the immune system's ability to fight the microbe. The findings, which appear in the July 17 issue of Nature, have implications for developing more effective anthrax therapies and guiding researchers in better controlling detrimental immune responses, such as in autoimmune diseases and organ rejection following transplant surgeries.

For his study, Dr. Pulendran, associate professor in the Department of Pathology and Laboratory Medicine at Emory University School of Medicine, and Anshu Agrawal, PhD, a post-doctoral fellow in his lab, in collaboration with Conrad Quinn, PhD, and Jai Lingappa, MD, at the Centers for Disease Control and Prevention, and Steve Leppla, PhD, at the National Institutes of Health, chose to study dendritic cells versus the previously studied macrophages. Dendritic cells are widely recognized as the most efficient antigen-presenting cells, making them pivotal in initiating and modulating any immune response against microbes.

"This is the first study that demonstrates any interaction between Bacillus anthracis and dendritic cells, " says Dr. Pulendran. "Our findings reveal a novel mechanism of action by which the microbe targets the host-immune reaction."

In the study, Dr. Pulendran's research team demonstrated that LF impairs dendritic cell function by disrupting the mitogen-activated protein (MAP) kinase enzymes within dendritic cells. Consequently, the dendritic cells become lethargic and unable to act normally, thereby preventing the activation of the immune system to attack microbes such as anthrax.

"When a person is infected with a microbe, we count on the immune system to begin fighting the foreign substance immediately," Dr. Pulendran commented. "When the d
'"/>

Contact: Lisa Newbern
lmnewbe@emory.edu
404-727-7709
Emory University Health Sciences Center
16-Jul-2003


Page: 1 2

Related biology news :

1. Emory researchers map structure of anti-cancer molecule
2. Hope Clinic of Emory Vaccine Center receives CDC contract
3. Emory scientists receive NIH MIDAS grant for computer modeling of infectious diseases
4. Emory researchers develop model to track the evolution of emerging infectious diseases
5. Emory scientists use enzymes to enhance regeneration of damaged peripheral nerves in mice
6. Emory scientists track down immune sentinel cells with gene gun
7. Emory scientists find anti-tumor compounds in magnolia cones
8. Emorys CancerQuest wins top Web award from Scientific American
9. Emory University researchers uncover novel self-assembly of Alzheimers amyloid fibrils
10. Emory Vaccine Research Center study identifies specific gene required for long-term immunity
11. Emory to receive more than $6.5 million to study environmental risk factors for Parkinsons disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/3/2019)... ... October 01, 2019 , ... ... dispensing of chemicals, reagents, and medias and to be a more environmentally sustainable ... the culmination of years of experience and feedback from the original version we ...
(Date:9/30/2019)... ... September 30, 2019 , ... As human induced pluripotent stem cells (hiPSCs) ... the development and diseases of the human heart, there is an increasing need for ... muscle cells to be clearly and easily recorded. A study released today in STEM ...
(Date:9/25/2019)... (PRWEB) , ... September 25, 2019 , ... ... biopharma leaders through off-the-record collaboration and dialogue, today announces its inaugural South ... Orleans BioInnovation Center in Louisiana. , Co-produced by Tulane University, this invitation-only ...
Breaking Biology News(10 mins):
(Date:10/10/2019)... (PRWEB) , ... October 09, 2019 , ... ... 10th, groups of Montgomery County middle school and high school students have improved ... stressors, utilize relaxation techniques and physical fitness, and apply lifelong social/interpersonal, leadership, problem-solving ...
(Date:10/8/2019)... ... , ... Today, Massachusetts stem cell biotechnology company Asymmetrex announces the ... precursor patent, approved in the U.S. in 2017, the new patent covers the company’s ... markets the technology in the U.S. as the AlphaSTEM Test™. The new patent ...
(Date:10/3/2019)... FAIRFAX, Va. (PRWEB) , ... October 02, 2019 , ... ... the prestigious NHS Digital Health Accelerator run by the East Midlands Academic Health Science ... up the adoption of technology in NHS by providing support to develop and deploy ...
(Date:9/24/2019)... Kong (PRWEB) , ... September 24, 2019 , ... Drug ... 2019 by the World Health Organization, with MRSA becoming one of the most serious ... there were 1,218 reported cases of community-associated MRSA (CA-MRSA), or a seven-fold of the ...
Breaking Biology Technology:
Cached News: