HOME >> BIOLOGY >> NEWS
Emory researchers map structure of anti-cancer molecule

Scientists at Emory University, in collaboration with researchers at three national laboratories, have solved the structural puzzle of how an emerging class of promising cancer drugs work to halt cell division. The discovery potentially opens the door to the creation of more effective cancer treatments.

"Uncovering and mapping the structure of this model system will assist scientists around the world in creating new compounds that hopefully will lead to new cancer drugs," says researcher Jim Snyder, an Emory chemist and director of biostructural research at the university.

The results, reported in the Aug. 6 issue of the journal Science, include the first three-dimensional, atomic-scale images of the binding site where one of the drugs, epothilone A, interacts with a key protein controlling cell division.

The researchers have now examined two drug families the epothilones and taxanes, which include the anti-cancer drug Taxol already in use. Both drugs work to halt the division of cancer cells by binding to the same site on a protein called tubulin that is involved in cell division. Tubulin is the major component of microtubules, the hollow cylinders that serve as a skeletal system for cells and a scaffold for chromosomes in the dividing cell. When epothilones or taxanes bind to tubulin, the protein loses its flexibility and the microtubules can no longer disassemble, halting cell division.

To build the model, the Emory team used diffraction data gathered from an electron microscope at Lawrence Berkeley National Laboratory. The data allowed them to "see" the differences in the atomic positions associated with the two drugs that explained their activities within a cell. The work involved using computers to test thousands of possible solutions against the diffractions along with extensive biological data regarding drug activity.

Jim Nettles, an Emory doctoral candidate
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
12-Aug-2004


Page: 1 2

Related biology news :

1. Hope Clinic of Emory Vaccine Center receives CDC contract
2. Emory scientists receive NIH MIDAS grant for computer modeling of infectious diseases
3. Emory researchers develop model to track the evolution of emerging infectious diseases
4. Emory scientists use enzymes to enhance regeneration of damaged peripheral nerves in mice
5. Emory scientists track down immune sentinel cells with gene gun
6. Emory researchers discover novel mechanism of how anthrax impairs immunity
7. Emory scientists find anti-tumor compounds in magnolia cones
8. Emorys CancerQuest wins top Web award from Scientific American
9. Emory University researchers uncover novel self-assembly of Alzheimers amyloid fibrils
10. Emory Vaccine Research Center study identifies specific gene required for long-term immunity
11. Emory to receive more than $6.5 million to study environmental risk factors for Parkinsons disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: