HOME >> BIOLOGY >> NEWS
Emory scientists find anti-tumor compounds in magnolia cones

ATLANTA - The beloved southern magnolia, state flower of Louisiana and Mississippi, could provide more to cancer patients than shade and pretty flowers. A team of scientists at Emory University School of Medicine has discovered that seed cones from magnolia trees contain substances that inhibit the growth of new blood vessels. The active ingredient in the magnolia cones inhibited the growth of blood vessel endothelial cells in the laboratory and cut tumor growth in half in experiments in mice. Researchers have been interested in this class of compounds, called angiogenesis inhibitors, for the last several years, and clinical trials are just now assessing their effectiveness against various kinds of cancer.

The team's research was published in the Journal of Biological Chemistry online on June 19. The research was performed in the laboratory of Jack Arbiser, MD, PhD, assistant professor of dermatology at Emory School of Medicine and a faculty member in the Winship Cancer Institute. Lead author was Xianhe Bai, PhD, Emory dermatology postdoctoral fellow. Collaborators include investigators from the University of North Carolina, Dana Farber Cancer Institute, Northwestern University, and Humboldt University in Berlin.

Tumors, once they begin growing, can't continue to grow past a certain size without the oxygen and nutrients that blood vessels provide. The most dangerous tumors secrete signals that tell the body to grow new blood vessels toward them. Angiogenesis inhibitors are designed to stop those signals from being received, and come in various forms. For example, the biotechnology firm Genentech's Avastin™, recently fast-tracked by the FDA for approval, is an antibody against a protein secreted by tumors vascular endothelial growth factor (VEGF). Recent clinical trials have demonstrated Avastin's effectiveness, in combination with chemotherapy, against colon cancer. Dr. Arbiser had previously developed a method for screening mixtures of
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
15-Jul-2003


Page: 1 2 3

Related biology news :

1. Emory researchers map structure of anti-cancer molecule
2. Hope Clinic of Emory Vaccine Center receives CDC contract
3. Emory scientists receive NIH MIDAS grant for computer modeling of infectious diseases
4. Emory researchers develop model to track the evolution of emerging infectious diseases
5. Emory scientists use enzymes to enhance regeneration of damaged peripheral nerves in mice
6. Emory scientists track down immune sentinel cells with gene gun
7. Emory researchers discover novel mechanism of how anthrax impairs immunity
8. Emorys CancerQuest wins top Web award from Scientific American
9. Emory University researchers uncover novel self-assembly of Alzheimers amyloid fibrils
10. Emory Vaccine Research Center study identifies specific gene required for long-term immunity
11. Emory to receive more than $6.5 million to study environmental risk factors for Parkinsons disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/25/2019)... ... September 25, 2019 , ... ... have placed over 20,000 dental implants for a variety of procedures, including single ... and pterygoid dental implants. Dental implants offer patients permanent tooth replacement ...
(Date:9/24/2019)... Mass. (PRWEB) , ... September 23, 2019 , ... ... US offices in Cambridge, MA, announce today that Holotype HLA and other Omixon ... annual meeting of the American Society for Histocompatibility and Immunogenetics (ASHI) ...
(Date:9/22/2019)... ... September 20, 2019 , ... ... are adjusting to client demands for precision medicine products. The report, Lab ... $19 billion in 2018, the pharma/bio sector is the largest source of demand ...
Breaking Biology News(10 mins):
(Date:10/8/2019)... Calif. (PRWEB) , ... October 08, 2019 , ... ... Master’s Project (TMP), Madhumita Suresh and Leslie Maurer presented company executives with a ... Business and Science (MBS) graduates will offer insights from their TMP to a ...
(Date:10/3/2019)... ... 2019 , ... Cheyenne is a beautiful and strong Quarter Horse and a ... Rebel’s Run , which offers riding lessons and trail riding in Afton, Virginia. ... Mimi describes her as her “go to horse.” Thus, you can imagine ...
(Date:10/3/2019)... ... October 02, 2019 , ... Rapid Novor, Inc., the world's ... it has moved into a new, 5000 sqft, purpose-built, state-of-the-art facility. Now home ... the company's continuous commitment to quality research and service offerings. , ...
(Date:9/24/2019)... ... September 24, 2019 , ... Drug resistance has been declared as one of ... MRSA becoming one of the most serious concerns. Hong Kong cannot be spared from ... MRSA (CA-MRSA), or a seven-fold of the figure in 2007 – the year the ...
Breaking Biology Technology:
Cached News: