HOME >> BIOLOGY >> NEWS
Emory scientists use enzymes to enhance regeneration of damaged peripheral nerves in mice

Scientists at Emory University School of Medicine were able to enhance significantly the re-growth of damaged peripheral nerves in mice by treating them with enzymes that counteracted a growth-blocking mechanism. The research offers the potential for improving functional recovery after peripheral nerve injuries. The Emory scientists were led by Arthur English, PhD, professor of cell biology, with faculty colleagues Robert McKeon, PhD and Erica Werner, PhD and former Emory student M.L. Groves. Results of the research will be presented at the annual meeting of the Society for Neuroscience on November 8 in New Orleans.

Peripheral nerves extend from the spinal cord to targets in the periphery such as muscle and skin. Individual peripheral nerves contain thousands of individual fibers, called axons, which project to specific targets. When a peripheral nerve is damaged, axons between the injury site and muscle or skin degenerate and function is lost. Although peripheral nerve axons are capable of regenerating after such injuries, in humans this regeneration is modest at best and there currently is no effective clinical treatment.

One reason peripheral nerves do not regenerate well is the presence of growth inhibitory substances, called proteoglycans, within the environment of the damaged nerve. In an effort to improve the ability of axons to regenerate, the Emory scientists attempted to modify this inhibitory environment following peripheral nerve injury in mice. They treated the peripheral portion of severed nerves with each of three enzymes that degrade specific types of proteoglycans.

During the first two weeks after the injury, axons regenerated through enzyme-treated tissues much more effectively than through untreated tissues. Not only did the axons regenerate, those that did extended more than twice as far.

"This study shows that treatment with enzymes that degrade proteoglycans offers the potential to enhance regenerat
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
8-Nov-2003


Page: 1 2

Related biology news :

1. Emory researchers map structure of anti-cancer molecule
2. Hope Clinic of Emory Vaccine Center receives CDC contract
3. Emory scientists receive NIH MIDAS grant for computer modeling of infectious diseases
4. Emory researchers develop model to track the evolution of emerging infectious diseases
5. Emory scientists track down immune sentinel cells with gene gun
6. Emory researchers discover novel mechanism of how anthrax impairs immunity
7. Emory scientists find anti-tumor compounds in magnolia cones
8. Emorys CancerQuest wins top Web award from Scientific American
9. Emory University researchers uncover novel self-assembly of Alzheimers amyloid fibrils
10. Emory Vaccine Research Center study identifies specific gene required for long-term immunity
11. Emory to receive more than $6.5 million to study environmental risk factors for Parkinsons disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2020)... ... August 06, 2020 , ... ... in the prestigious National STEM Scholar Program, a unique professional development program that ... project support for middle school science teachers nationwide. , Created in partnership between ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... therapeutics product portfolio with a near term focus on Type 2 diabetes and ... commercialization experience across multiple therapeutic areas and classes. As Chief Commercial Officer, Justin ...
(Date:7/10/2020)... ... 08, 2020 , ... Overcoming Comparability Issues in Regenerative Medicines ... Wednesday, July 22, 2020 • 1:30 p.m.-3:00 p.m. EDT, https://www.fdanews.com/cellandgenetherapy , ... way to complete one? Will the study comply with all FDA requirements? Understanding ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... , ... August 11, 2020 , ... ... year to expand the Facioscapulohumeral Muscular Dystrophy Clinical Trial Research Network ... and 2022. The network is a consortium of academic research centers in the ...
(Date:8/3/2020)... ... 03, 2020 , ... Introducing Ardent Animal Health – MediVet Biologics rebrands company ... Known as MediVet Biologics since its formation in 2016, the company is relaunching ... Health will build on its base of innovative therapies for osteoarthritis and cancer. ...
(Date:7/31/2020)... SOMERSET, N.J (PRWEB) , ... July 29, 2020 ... ... editing company, and Catalent, the leading global provider of advanced delivery technologies, development, ... products, today announced that they have entered into a strategic partnership whereby Catalent ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and catheter implantation, ... surgery is only the beginning of a successful study, while protecting and accessing the ... Gien, Global Head of Surgery from Envigo in a live webinar ...
Breaking Biology Technology:
Cached News: