HOME >> BIOLOGY >> NEWS
Endometriosis: Could angiostatic therapy be the new treatment of the future?

Berlin, Germany: Chemicals that inhibit the development of new blood vessels could prove to be a new way of treating endometriosis, according to research from The Netherlands and the USA presented today (Monday 28 June) at the 20th annual meeting of the European Society of Human Reproduction and Embryology.

However, the researchers warned that the work is still at an early stage, with the current investigations taking place in mice, so it would be a few years before the findings could translate into improved treatments for women with the disease.

Endometriosis is a disease of the lining tissue of the womb. It can be very painful and can have a serious impact on the lives of women. At present, there is no satisfactory treatment or cure for the condition, which affects between 10-25% of women of reproductive age1.

Annemiek Nap, a doctor at the University Hospital Maastricht, The Netherlands, told the conference that she and her colleagues tested whether angiostatic therapy (therapy that inhibits the development of blood vessels) could prevent new endometriosis lesions growing and whether it could interfere with the maintenance and growth of existing lesions.

They used four angiostatic compounds: anti-human vascular endothelial growth factor (anti-hVGF), TNP-470, endostatin and anginex. They tested the compounds on human endometrium that had been transplanted into 49 mice and allowed to grow into endometriotic lesions. "We thought that using human endometrium would make the model as close to the human situation as possible," said Ms Nap.

"We found that angiostatic therapy inhibits the number of newly developed blood vessels around lesions. However, the mature vessels, which are protected by smooth muscle cells, were not inhibited. We also observed that the number of endometriotic lesions in mice treated with angiostatic agents was lower than the number of endometriotic lesions in mice not treated with angiostatic agents."
'"/>

Contact: Mary Rice
mary.rice@blueprintpartners.be
European Society for Human Reproduction and Embryology
28-Jun-2004


Page: 1 2 3

Related biology news :

1. Could mice hold the secret to longer life?
2. Could vitamins raise levels of bad cholesterol? Animal study suggests they might
3. Could memory performance and spatial learning be genetically based?
4. Could a specific protein contribute to erectile dysfunction for the diabetic and obese?
5. Could diabetes treatments fight cancer?
6. Could rice be the source for a natural herbicide?
7. Could hibernators hold the key to improving organ preservation?
8. Could Bt transgenic crops have nutritionally favourable effects on insects?
9. Could one less cookie a day help the fight against fat?
10. Could an anti-marijuana compound hold the key to body weight and appetite control?
11. Study finds genetic aberrations linked to lung cancer; Could help in early diagnosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/16/2019)... (PRWEB) , ... June 14, 2019 , ... ... multi-pillar Oracle Cloud customer, will deliver a joint presentation with Versiti’s CIO at ... June 16-19 at the Rosen Shingle Creek Resort. , Versiti Vice President and ...
(Date:6/11/2019)... Ind. (PRWEB) , ... June 10, 2019 , ... Improved ... in the July 2019 issue of AAPS PharmSciTech. The article was published online on ... of Improved Pharma, along with Xiaoming Sean Chen of Purdue University. , The ...
(Date:6/4/2019)... ... June 04, 2019 , ... ... appointment of Susan Murphy as the new President of Molecular Devices, replacing Greg ... Devices’ parent company, Danaher Corporation. , Since joining Molecular Devices in a scientific ...
Breaking Biology News(10 mins):
(Date:7/9/2019)... , ... July 08, 2019 , ... Today, at the ... the National Corn Growers Association (NCGA) announced the winners of the Consider ... a product or process using field corn to produce biobased materials. , “Corn is ...
(Date:7/2/2019)... ... July 02, 2019 , ... Leading Regenerative Veterinary Medicine company, VetStem Biopharma ... Biotech. The film focuses on regenerative veterinary medicine as a means of improving ... recently included in the Brentwood and Pacific Palisades International Film Festival in Los ...
(Date:6/18/2019)... ... June 17, 2019 , ... IVERIC bio, ... an agreement for production and manufacturing of GMP-grade adeno-associated virus (AAV) vector for ... dominant retinitis pigmentosa (RHO-adRP) and IC-200 for the treatment of BEST1 related retinal ...
(Date:6/12/2019)... , ... June 12, 2019 , ... ... helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging ... has been signed. The agreement will grant exclusive rights for Zillion to represent ...
Breaking Biology Technology:
Cached News: