Endometriosis: Could angiostatic therapy be the new treatment of the future?

Berlin, Germany: Chemicals that inhibit the development of new blood vessels could prove to be a new way of treating endometriosis, according to research from The Netherlands and the USA presented today (Monday 28 June) at the 20th annual meeting of the European Society of Human Reproduction and Embryology.

However, the researchers warned that the work is still at an early stage, with the current investigations taking place in mice, so it would be a few years before the findings could translate into improved treatments for women with the disease.

Endometriosis is a disease of the lining tissue of the womb. It can be very painful and can have a serious impact on the lives of women. At present, there is no satisfactory treatment or cure for the condition, which affects between 10-25% of women of reproductive age1.

Annemiek Nap, a doctor at the University Hospital Maastricht, The Netherlands, told the conference that she and her colleagues tested whether angiostatic therapy (therapy that inhibits the development of blood vessels) could prevent new endometriosis lesions growing and whether it could interfere with the maintenance and growth of existing lesions.

They used four angiostatic compounds: anti-human vascular endothelial growth factor (anti-hVGF), TNP-470, endostatin and anginex. They tested the compounds on human endometrium that had been transplanted into 49 mice and allowed to grow into endometriotic lesions. "We thought that using human endometrium would make the model as close to the human situation as possible," said Ms Nap.

"We found that angiostatic therapy inhibits the number of newly developed blood vessels around lesions. However, the mature vessels, which are protected by smooth muscle cells, were not inhibited. We also observed that the number of endometriotic lesions in mice treated with angiostatic agents was lower than the number of endometriotic lesions in mice not treated with angiostatic agents."

Contact: Mary Rice
European Society for Human Reproduction and Embryology

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