HOME >> BIOLOGY >> NEWS
Engineered Neo-Organs For Bladder Replacement

In this research, the investigators created a new form of bladder in vitro, outside the living organism in the lab, and implanted it in 6 beagle dogs. For this study, a total of 14 beagles had a cystectomy. Two dogs underwent closure without a reconstructive procedure. Six beagles had bladder reconstruction with a cell-free biodegradable polymer. The third group of six dogs received reconstruction using a bladder-shaped biodegradable polymer that delivered autologous cells from the bladder epithelium, plus smooth muscle cells. The cells had been expanded separately from a previously harvested autologous bladder biopsy. The researchers performed preoperative and postoperative urinary flow and X-ray studies. After their initial operation and recovery, the animals were sacrificed at 1,2,3,4,6 and 11 months. The investigators performed gross pathology, along with histological and other analyses. Their results showed that in the tissue engineered replacement bladders, the average bladder capacity was 95% of the original pre- cystectomy volume. The polymer-only grafts were 46% of preoperative values, and the cystectomy-only controls were at 22%. The compliance of the tissue-engineered bladders (the quality of yielding to fluid pressure) showed almost no difference from pre-operative values. In their analysis, the investigators found that the retrieved tissue engineered bladders had normal cellular organization, consisting of a tri-layer of normal bladder epithelium, submucosa, and muscle. The investigators believe that tissue engineering can create functionally and anatomically normal bladders. They assert that this technology in the future could improve or even supplant conventional methods of bladder replacement or augmentation.


'"/>

Contact: Bill Glitz
wglitz@aol.com
703-532-3797
American Urological Association
31-May-1998


Page: 1

Related biology news :

1. Engineered virus provides impetus in search for HIV vaccine
2. Engineered proteins will lead to synthetic biology
3. Engineered mice point to new target for pain relief
4. Engineered Corn Can Kill Monarch Butterflies
5. Engineered Bacteria Scavenge Heavy Metals
6. Genetically Engineered Mice Exhibit Anxiety, Offering Insight Into Role Of Serotonin In Brain
7. Genetically Engineered Mice Show Characteristic Signs Of Alzheimers, Could Be Ideal Tool For Testing New Therapies
8. Body Building: Tissue Engineered Organs A Heartbeat Away
9. Jefferson Researchers First To Create Genetically Engineered Mouse To Study Photoaging
10. Two-Pronged Attack On Immune System Cells Engineered By HIV Gene vpr: Effects Markedly Reversed By Antisteroid Compound RU-486
11. Three-Way Gene-Gene-Environmental Exposure Interaction Shown By NIEHS To Escalate Smoking-Related Bladder Cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/15/2016)... , April 15, 2016  A new partnership ... more accurate underwriting decisions in a fraction of ... competitively priced and high-value life insurance policies to ... With Force Diagnostics, rapid testing (A1C, ... data readings (blood pressure, weight, pulse, BMI, and ...
(Date:3/31/2016)...  Genomics firm Nabsys has completed a financial  restructuring ... , M.D., who returned to the company in October ... team, including Chief Technology Officer, John Oliver , ... and Vice President of Software and Informatics, Michael ... Dr. Bready served as CEO of Nabsys from 2005-2014 ...
(Date:3/21/2016)... 22, 2016 Unique technology ... for superior security   Xura, ... of secure digital communications services, today announced it is ... offer enterprise customers, particularly those in the Financial Services ... voice authentication within a mobile app, alongside, and in ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... May 25, 2016 , ... The ... by the Office of the National Coordinator for Health IT (ONC) outlining a ... clinically relevant data were available when and where it was needed. The organization ...
(Date:5/25/2016)... , ... May 25, 2016 , ... WEDI, the nation’s ... exchange, today announced that Charles W. Stellar has been named by the WEDI Board ... since January 2016. As an executive leader with more than 35 years of experience ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... and Drug Administration (FDA) has granted the company’s orphan drug designation request covering ... orphan drug designation granted by the FDA. , Spinocerebellar ataxia is a ...
(Date:5/24/2016)... Israel , May 24, 2016   MedyMatch Technology ... physicians with artificial intelligence, real-time decision support tools in the ... present at the 2016 Israeli Advanced Technology Industries (IATI) BioMed ... Israel,s 15th National Life Sciences and ... at the David Intercontinental Hotel in Tel Aviv, ...
Breaking Biology Technology:
Cached News: