HOME >> BIOLOGY >> NEWS
Engineered Neo-Organs For Bladder Replacement

In this research, the investigators created a new form of bladder in vitro, outside the living organism in the lab, and implanted it in 6 beagle dogs. For this study, a total of 14 beagles had a cystectomy. Two dogs underwent closure without a reconstructive procedure. Six beagles had bladder reconstruction with a cell-free biodegradable polymer. The third group of six dogs received reconstruction using a bladder-shaped biodegradable polymer that delivered autologous cells from the bladder epithelium, plus smooth muscle cells. The cells had been expanded separately from a previously harvested autologous bladder biopsy. The researchers performed preoperative and postoperative urinary flow and X-ray studies. After their initial operation and recovery, the animals were sacrificed at 1,2,3,4,6 and 11 months. The investigators performed gross pathology, along with histological and other analyses. Their results showed that in the tissue engineered replacement bladders, the average bladder capacity was 95% of the original pre- cystectomy volume. The polymer-only grafts were 46% of preoperative values, and the cystectomy-only controls were at 22%. The compliance of the tissue-engineered bladders (the quality of yielding to fluid pressure) showed almost no difference from pre-operative values. In their analysis, the investigators found that the retrieved tissue engineered bladders had normal cellular organization, consisting of a tri-layer of normal bladder epithelium, submucosa, and muscle. The investigators believe that tissue engineering can create functionally and anatomically normal bladders. They assert that this technology in the future could improve or even supplant conventional methods of bladder replacement or augmentation.


'"/>

Contact: Bill Glitz
wglitz@aol.com
703-532-3797
American Urological Association
31-May-1998


Page: 1

Related biology news :

1. Engineered virus provides impetus in search for HIV vaccine
2. Engineered proteins will lead to synthetic biology
3. Engineered mice point to new target for pain relief
4. Engineered Corn Can Kill Monarch Butterflies
5. Engineered Bacteria Scavenge Heavy Metals
6. Genetically Engineered Mice Exhibit Anxiety, Offering Insight Into Role Of Serotonin In Brain
7. Genetically Engineered Mice Show Characteristic Signs Of Alzheimers, Could Be Ideal Tool For Testing New Therapies
8. Body Building: Tissue Engineered Organs A Heartbeat Away
9. Jefferson Researchers First To Create Genetically Engineered Mouse To Study Photoaging
10. Two-Pronged Attack On Immune System Cells Engineered By HIV Gene vpr: Effects Markedly Reversed By Antisteroid Compound RU-486
11. Three-Way Gene-Gene-Environmental Exposure Interaction Shown By NIEHS To Escalate Smoking-Related Bladder Cancer

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Engineered Neo Organs For Bladder Replacement

(Date:10/29/2014)... lose their hair as a consequence of chemotherapy will ... the scalp cooling technology that prevents hair loss. , ... pioneered by global scalp cooling manufacturing company, Paxman Coolers, ... department of the University of Huddersfield. , The research ... has a background in the pharmacology of cancer treatment, ...
(Date:10/29/2014)... registration is open for the Society ... Meeting. SIR 2015 is the one place ... and related health care professionals can come ... science and technologies being presented, discussed and ... in minimally invasive, image-guided medicine, SIR 2015 ...
(Date:10/29/2014)... of chemicals from household and industrial products are in ... But for most of them, scientists have yet to ... the first step toward doing that by estimating which ... method is published in the ACS journal Environmental ... colleagues note that the risks to human health of ...
Breaking Biology News(10 mins):New technology on the way to aid cancer suffers who lose their hair after chemotherapy 2SIR 2015: Interventional radiology shapes tomorrow's medicine 2
(Date:10/31/2014)... 31, 2014 Having access to safe ... uphill battle in many corners of the globe. It’s ... community in northwestern Bolivia where many have been sickened ... from Fairfield University’s School of Engineering has been working ... Campesina (UAC), “the united college for the peasants.” A ...
(Date:10/31/2014)... Burlington, MA (PRWEB) October 31, 2014 ... is hosting a free learning webinar to introduce its ... managers, standards directors and biostatisticians. , Launched in September, ... the company's suite of clinical trial automation tools. For ... in a web browser. And by introducing Formations – ...
(Date:10/31/2014)... (PRWEB) October 31, 2014 Stronger ... healthcare, construction, finance and consumer electronics will help ... reason, industry research firm IBISWorld has added a ... its growing industry report collection. , The Biometrics ... for biometric technologies such as fingerprint, iris, retina ...
(Date:10/30/2014)... 30, 2014  Ardelyx, Inc. (NASDAQ: ... cardio-renal, gastrointestinal and metabolic diseases, today announced that ... on Thursday, November 6, 2014. Following the announcement, ... conference call and webcast at 4:30pm ET to ... business update. The live webcast can ...
Breaking Biology Technology:Fairfield University School of Engineering project reduces illness in rural community 2Fairfield University School of Engineering project reduces illness in rural community 3Formedix to Introduce "Revolutionary" Clinical Trial Automation Software with Learning Webinar 2Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 2Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 3Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2
Cached News: