HOME >> BIOLOGY >> NEWS
Enzyme Required To Prolong Life In Worms Identified By Researchers At Columbia; Key Enzyme Appears To Protect Animal Cells From Oxidative Damage

Researchers at Columbia University have discovered an enzyme that is required to prolong the life span of microscopic roundworms and that strains of long-lived worms appear to produce in greater quantity than normal.

They believe the enzyme, called cytosolic catalase, protects cells from oxidative damage, considered a key element in the aging process in all animals, including humans. Because oxidative damage has been implicated in Alzheimer's and Lou Gehrig's disease, the work may prompt medical researchers to ask new questions about such nervous system diseases.

"Our work demonstrates that oxidative damage is an important determinant of life span, and control of such damage might affect the life span of other organisms," said Martin Chalfie, professor of biological sciences at Columbia and leader of the team that produced the research, which is described in the May 13 issue of the British journal Nature.

The research was carried out in Caenorhabditis elegans, a soil worm about 1/25 of an inch long that is a common experimental animal. The tiny worm has been useful to aging research because its normal three-week life span can be extended by environmental factors. In situations of overcrowding, food shortages or both, the emerging worm goes into a dormant period that can last as long as two months. If food is provided within that time, the animal emerges from dormancy and goes on to live its normal three weeks.

Scientists studying a possible genetic component to life span have been fascinated by this extended larval phase, called the dauer stage. "Dauer" means "lasting" in German. Several scientific teams have found mutations that send the worm into the dauer state at elevated temperatures. But even at normal temperatures and without going into the dauer stage, these mutant adults live two to four times longer than non-mutants. Yet these same mutants, if also bred to lack cytosolic catalase, died af
'"/>

Contact: Bob Nelson, Office of Public Affairs
rjn2@columbia.edu
212-854-6580
Columbia University
12-May-1999


Page: 1 2 3 4

Related biology news :

1. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
2. Enzyme activation appears key in helping internal clock tell night from day
3. Enzyme fully degrades mad cow disease prion
4. Enzyme revealed that is key to funguss ability to breach immune system
5. Enzyme discovery sheds light on causes of rare disease, cancer
6. Enzyme could overcome industrial bleaching waste problems
7. Enzyme controls good cholesterol
8. Enzyme discovery to benefit homeland security, industry
9. Enzyme could aid cancer fight
10. Enzyme once thought harmful to Alzheimers patients now appears key to future treatment
11. Enzyme mimetic reduces tissue damage in colitis animal study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/6/2017)... Forecasts by Product Type (EAC), ... End-Use (Transportation & Logistics, Government & Public Sector, Utilities ... Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), ... you looking for a definitive report on the $27.9bn ... ...
(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
(Date:3/28/2017)... 2017 The report "Video Surveillance ... Servers, Storage Devices), Software (Video Analytics, VMS), and Service ... Forecast to 2022", published by MarketsandMarkets, the market was ... projected to reach USD 75.64 Billion by 2022, at ... base year considered for the study is 2016 and ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... ... A recent survey conducted by the Weed Science Society of America (WSSA) ranks ... of broadleaf crops, fruits and vegetables, while common lambsquarters ranks as the weed most ... the 2016 survey, the second conducted by WSSA. A 2015 baseline survey explored ...
(Date:5/23/2017)... ... , ... Vortex Biosciences , provider of circulating tumor cell (CTC) capture ... using Vortex microfluidic technology ” in Nature Precision Oncology on May 8th. The ... and Dr. Matthew Rettig at the University of California, Los Angeles. The publication describes ...
(Date:5/23/2017)... ... 23, 2017 , ... Customers often prefer PLC and ... again. METTLER TOLEDO has released two new videos that show how they have ... the ACT350 into Siemens and Allen Bradley PLCs is easy and fast. ...
(Date:5/21/2017)... Diego, CA (PRWEB) , ... May 20, 2017 ... ... support tool that helps avoid the lengthy trial and error process by finding ... patients. It can also strengthen the doctor-patient relationship through a personalized approach ...
Breaking Biology Technology:
Cached News: