HOME >> BIOLOGY >> NEWS
Enzyme activation appears key in helping internal clock tell night from day

CHAMPAIGN, Ill. -- Feel like time is repeating itself and won't move on? It could be your internal clock is backpedaling because your PKG-II is out of whack.

That scenario was played out at the University of Illinois at Urbana-Champaign in experiments at a molecular level deep within the brain of rats where, like in all mammals, the primary circadian clock is located. The clock is a dynamic biological process with a near-24-hour cycle. PKG-II is an enzyme, a protein that triggers biochemical reactions.

Reporting in the Aug. 19 issue of the journal Neuron, the Illinois scientists say that the activation of PKG-II may be the critical control point that tells our biological clock to proceed by putting night behind and journeying into a new day.

In their research, the scientists blocked the phosphorylation action of PKG-II during the normal cycling of the clock. By doing so, they disrupted the key activity of this kinase enzyme that adds phosphates to proteins, a signaling mechanism necessary for information transfer in cells.

The internal clock produces the 24-hour rhythm in the brain and all cells. The cycle consists of an automatically regulated loop of transcription and translation of special clock genes, whose products act as "gears" of the clockwork. Correct cycling is vital to the oscillation of metabolism and behaviors, which happen during sleep and wakefulness.

"Without PKG-II, the clock behaves as if locked in a dynamic loop that encompasses the biochemical state of late night," the researchers wrote. "By potentially interacting with CLOCK (a critical protein of the central clockwork) during its phosphorylation, PKG-II may influence core clock components to signal the completion of nighttime processes and permit transit to the daytime domain. Thus, clock-controlled activation of PKG-II may serve as a critical checkpoint of temporal state at the night-to-day transition, which would align with dawn in the solar cycl
'"/>

Contact: Jim Barlow, Life Sciences Editor
jebarlow@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
18-Aug-2004


Page: 1 2

Related biology news :

1. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
2. Enzyme fully degrades mad cow disease prion
3. Enzyme revealed that is key to funguss ability to breach immune system
4. Enzyme discovery sheds light on causes of rare disease, cancer
5. Enzyme could overcome industrial bleaching waste problems
6. Enzyme controls good cholesterol
7. Enzyme discovery to benefit homeland security, industry
8. Enzyme could aid cancer fight
9. Enzyme once thought harmful to Alzheimers patients now appears key to future treatment
10. Enzyme mimetic reduces tissue damage in colitis animal study
11. Enzyme studies at Brookhaven Lab may lead to new antiviral agents

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/25/2019)... ... 25, 2019 , ... Researchers have found multiple applications for ... came into use by the scientific community. Keck Graduate Institute (KGI) Assistant Professor ... combine the power of CRISPR’s nucleic acid targeting with the ultra sensitivity of ...
(Date:3/18/2019)... SAN DIEGO (PRWEB) , ... March 18, 2019 , ... ... lead to tooth loss, affects nearly 50% of the US population. Making this ... surfaces in a biofilm state, where the cells are enmeshed in a sticky extracellular ...
(Date:3/14/2019)... ... March 13, 2019 , ... Bode Technology (Bode), a leading provider of ... more than 100,000 sexual assault kits. As thousands of untested kits are identified across ... assault kit backlogs . Bode has tested more than 50,000 kits in the last ...
Breaking Biology News(10 mins):
(Date:3/14/2019)... ... March 14, 2019 , ... Xybion ... research organizations. It is a low code, GDPR/21 CFR Part 11-compliant digital ... technology-driven automated data capture and seamless data and information management. , ...
(Date:3/11/2019)... Calif. (PRWEB) , ... March 11, 2019 , ... ... solution for enterprise content and information management with built in GxP compliance for the ... Generis customers to manage GxP validation and continuous compliance for Generis’ flagship ...
(Date:3/5/2019)... HOUSTON Texas (PRWEB) , ... March 05, 2019 ... ... is a biopharmaceutical cold chain engineering firm with regulatory filing authorities, logistics network ... corporate information to initiate its participation in the Inc. Verified Profile program, ...
(Date:2/26/2019)... , ... February 26, 2019 , ... ... when Visikol Co-Founder Dr. Thomas Villani developed the Visikol® tissue clearing technology for ... has since transitioned from a products focused company to primarily a services focused ...
Breaking Biology Technology:
Cached News: