HOME >> BIOLOGY >> NEWS
Enzyme controls 'good cholesterol'

HOUSTON--(Feb. 26, 2003)--A recently discovered enzyme called endothelial lipase regulates the structure, metabolism and blood concentration of high density lipoprotein (HDL), the so-called "good cholesterol," said researchers from Baylor College of Medicine in a report in the online version of the Proceedings of the National Academy of Sciences.

In a series of studies in mice, Dr. Lawrence Chan, chief of the section of endocrinology and metabolism at Baylor, his co-workers and colleagues from the section of cardiology and atherosclerosis have found that when mice lack this enzyme, the particles of HDL in their blood are much larger than normal.

"We don't know if it is good or bad that the HDL becomes larger," said Chan. "We were always taught that high levels of HDL are good for you because HDL carries cholesterol from the outer areas of the body back to the liver where it is excreted as bile."

High levels of HDL may also inhibit inflammation, a newly accepted factor in coronary heart disease, Chan said.

"It also protects the vascular wall," he said. "It may also slow down the oxidation of low density lipoprotein (the so-called bad cholesterol). Oxidized LDL is very bad."

A variant of the enzyme that is found in approximately 26 percent of people is associated with high levels of HDL, he said. He and his colleagues are studying the fate of patients with this type of enzyme to determine whether it is beneficial or not.

Once they determine whether the variant form of HDL is good or bad, it can become a target for drug developers who will attempt to manipulate levels of "good" cholesterol through this mechanism.

One concern is that the larger particles of HDL might slow the transport of cholesterol back to the liver, which probably would not be good, said Chan. While HDL might have all the good actions including working against inflammation and protecting the vascular wall, that would have to be balanced against the interruptio
'"/>

Contact: Anissa Anderson Orr
anissaa@bcm.tmc.edu
713-798-4712
Baylor College of Medicine
26-Feb-2003


Page: 1 2

Related biology news :

1. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
2. Enzyme activation appears key in helping internal clock tell night from day
3. Enzyme fully degrades mad cow disease prion
4. Enzyme revealed that is key to funguss ability to breach immune system
5. Enzyme discovery sheds light on causes of rare disease, cancer
6. Enzyme could overcome industrial bleaching waste problems
7. Enzyme discovery to benefit homeland security, industry
8. Enzyme could aid cancer fight
9. Enzyme once thought harmful to Alzheimers patients now appears key to future treatment
10. Enzyme mimetic reduces tissue damage in colitis animal study
11. Enzyme studies at Brookhaven Lab may lead to new antiviral agents

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/16/2019)... ... June 14, 2019 , ... Respected periodontist, Dr. Dan ... annual Neodent World Congress. Attended by thousands of dental clinicians from all over ... the world of dentistry. The three-day event featured a team of expert speakers ...
(Date:6/13/2019)... ... , ... KICVentures announced today its plans to host an event ... ASC Conference in Chicago on Thursday, June 13th at 6:30 pm. The event will ... the 3rd floor Ticino Hospitality room in space #74T. , The event will feature ...
(Date:6/11/2019)... Ind. (PRWEB) , ... June 10, 2019 , ... Improved ... in the July 2019 issue of AAPS PharmSciTech. The article was published online on ... of Improved Pharma, along with Xiaoming Sean Chen of Purdue University. , The ...
Breaking Biology News(10 mins):
(Date:5/21/2019)... ... May 21, 2019 , ... ... today officially opened the inaugural Africa Brewing Conference dedicated to sharing brewing knowledge, ... Africa. The event, which is supported through a partnership with “Ethiopia Invest”, will ...
(Date:5/15/2019)... ... May 16, 2019 , ... Emulsifiers are the magic ... beverage products rely on these ingredients to create stable quality food that can ... paradigm shift triggers food formulators to seek out alternatives for starches, gums and ...
(Date:5/14/2019)... ... May 14, 2019 , ... Gateway Genomics , a leading developer ... from 2,500 to 5,000 square feet. , “This past year has seen exponential ... Gateway Genomics CEO, Chris Jacob. “The SneakPeek At-Home test, which is mailed directly to ...
(Date:5/7/2019)... ... 06, 2019 , ... "The new Liquid Nitrogen Best Practices ... asked to store cellular products being used in adoptive therapy research and ... leaders, who have shared their expertise in building and managing facilities to support ...
Breaking Biology Technology:
Cached News: