HOME >> BIOLOGY >> NEWS
Enzyme discovery to benefit homeland security, industry

RICHLAND, Wash. - Scientists at the Department of Energy's Pacific Northwest National Laboratory have successfully immobilized enzymes while simultaneously enhancing their activity and stability, opening up new possibilities for using tailored nanoporous materials. The findings, reported in an upcoming issue of the Journal of the American Chemical Society (available online Aug. 28), could enable the development of novel sensor and decontamination systems for homeland security, environmental protection and energy generation as well as new industrial chemicals and separations.

"For decades, scientists have been searching for ways to immobilize soluble enzymes with a variety of solid materials. But the results have been disappointing because only small amounts of the immobilized enzymes show any biological activity," said Eric Ackerman, PNNL molecular biologist. "For the first time, we have immobilized an enzyme at high concentrations in a way that actually enhances its stability and activity."

In lab tests, PNNL scientists nearly doubled the activity levels of an enzyme called organophosphorus hydrolase, known for its potential for biosensing and decontaminating poisonous agents.

"By using different highly active and stable immobilized enzymes, we could potentially make enzymatic systems to inactivate certain chemicals or bioweapons, thus serving as a protective barrier in air filtration systems," said Ackerman.

Fabrication of a more stable and active enzyme delivery method could potentially benefit other industries as well. For example, food processing companies use natural enzymes to produce items such as cheese, beer and soft drinks, while the biomedical industry uses them to manufacture drugs. Enzymes, which are proteins found in all organisms from humans to viruses, function as catalysts. Increasing an enzyme's activity - while enhancing enzyme stability - could facilitate more efficient chemical processes.

To achieve enhanced
'"/>

Contact: Staci Maloof
staci.maloof@pnl.gov
509-372-6313
DOE/Pacific Northwest National Laboratory
12-Sep-2002


Page: 1 2

Related biology news :

1. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
2. Enzyme activation appears key in helping internal clock tell night from day
3. Enzyme fully degrades mad cow disease prion
4. Enzyme revealed that is key to funguss ability to breach immune system
5. Enzyme discovery sheds light on causes of rare disease, cancer
6. Enzyme could overcome industrial bleaching waste problems
7. Enzyme controls good cholesterol
8. Enzyme could aid cancer fight
9. Enzyme once thought harmful to Alzheimers patients now appears key to future treatment
10. Enzyme mimetic reduces tissue damage in colitis animal study
11. Enzyme studies at Brookhaven Lab may lead to new antiviral agents

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/26/2017)... , Feb. 25, 2017  Securus Technologies, ... technology solutions for public safety, investigation, corrections and ... Recidivism and Reentry. "Too often, too ... prisons and county jails are trying to tackle ... inmates and friends and family members. While significant steps ...
(Date:2/21/2017)... February 21, 2017 Der weltweite ... wachsen. Nach einem Gespräch mit mehr als 50 Vertretern aus ... zu überwinden gilt, um diese Prognose zu realisieren. ... ... Mobilisierung der finanziellen Mittel für die Biobank, die Implementierung ...
(Date:2/13/2017)... Feb. 13, 2017 Former 9/11 Commission border ... Committee, Janice Kephart of Identity Strategy Partners, ... Donald Trump,s "Executive Order: Protecting the Nation From ... 2017):  "As President Trump,s ,Travel Ban, Executive ... now essentially banned the travel ban, it is important ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... ... , ... March 22, 2017...Council for Agricultural Science and Technology, Ames, Iowa. ... innovation in smart, sustainable ways. Humans depend on plants for food, feed, fiber, and ... This paper is the first in a series that connects science and technology to ...
(Date:3/22/2017)...  RXi Pharmaceuticals Corporation (NASDAQ: RXII), a clinical-stage ... unmet medical needs, today announced Alexey Eliseev ... at the 5th Annual Cancer BioPartnering & Investment ... present to and meet with thought leaders from ... as well as institutional investors. This event will ...
(Date:3/20/2017)... ... March 20, 2017 , ... ... the ability of endogenous hormones to regulate homeostasis via their cognate nuclear ... EDCs produce adverse reproductive, neurological, proliferative, and immunological disorders. EDC exposure can ...
(Date:3/20/2017)... ... March 20, 2017 , ... ... sample preparation methods in order to reduce the impact on instrumentation. ICP-MS is ... area of elemental analysis. , This presentation will discuss the pros and ...
Breaking Biology Technology:
Cached News: