Enzyme discovery to benefit homeland security, industry

RICHLAND, Wash. - Scientists at the Department of Energy's Pacific Northwest National Laboratory have successfully immobilized enzymes while simultaneously enhancing their activity and stability, opening up new possibilities for using tailored nanoporous materials. The findings, reported in an upcoming issue of the Journal of the American Chemical Society (available online Aug. 28), could enable the development of novel sensor and decontamination systems for homeland security, environmental protection and energy generation as well as new industrial chemicals and separations.

"For decades, scientists have been searching for ways to immobilize soluble enzymes with a variety of solid materials. But the results have been disappointing because only small amounts of the immobilized enzymes show any biological activity," said Eric Ackerman, PNNL molecular biologist. "For the first time, we have immobilized an enzyme at high concentrations in a way that actually enhances its stability and activity."

In lab tests, PNNL scientists nearly doubled the activity levels of an enzyme called organophosphorus hydrolase, known for its potential for biosensing and decontaminating poisonous agents.

"By using different highly active and stable immobilized enzymes, we could potentially make enzymatic systems to inactivate certain chemicals or bioweapons, thus serving as a protective barrier in air filtration systems," said Ackerman.

Fabrication of a more stable and active enzyme delivery method could potentially benefit other industries as well. For example, food processing companies use natural enzymes to produce items such as cheese, beer and soft drinks, while the biomedical industry uses them to manufacture drugs. Enzymes, which are proteins found in all organisms from humans to viruses, function as catalysts. Increasing an enzyme's activity - while enhancing enzyme stability - could facilitate more efficient chemical processes.

To achieve enhanced

Contact: Staci Maloof
DOE/Pacific Northwest National Laboratory

Page: 1 2

Related biology news :

1. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
2. Enzyme activation appears key in helping internal clock tell night from day
3. Enzyme fully degrades mad cow disease prion
4. Enzyme revealed that is key to funguss ability to breach immune system
5. Enzyme discovery sheds light on causes of rare disease, cancer
6. Enzyme could overcome industrial bleaching waste problems
7. Enzyme controls good cholesterol
8. Enzyme could aid cancer fight
9. Enzyme once thought harmful to Alzheimers patients now appears key to future treatment
10. Enzyme mimetic reduces tissue damage in colitis animal study
11. Enzyme studies at Brookhaven Lab may lead to new antiviral agents

Post Your Comments:

(Date:3/29/2016)... 2016 LegacyXChange, Inc. (OTC: ... SelectaDNA/CSI Protect are pleased to announce our successful effort ... variety of writing instruments, ensuring athletes signatures against counterfeiting ... from athletes on LegacyXChange will be assured of ongoing ... Bill Bollander , CEO states, "By ...
(Date:3/22/2016)... PUNE, India , March 22, 2016 ... new market research report "Electronic Sensors Market for ... Fingerprint, Proximity, & Others), Application (Communication & ... and Geography - Global Forecast to 2022", ... consumer industry is expected to reach USD ...
(Date:3/21/2016)... , March 22, 2016 ... recognition with passcodes for superior security   ... a leading provider of secure digital communications services, today ... biometric technology and offer enterprise customers, particularly those in ... facial recognition and voice authentication within a mobile app, ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... ... medical technologies, services and solutions to the healthcare market. The company's primary focus ... distribution, manufacturing, sales and marketing strategies that are necessary to help companies efficiently ...
(Date:6/24/2016)... DIEGO , June 24, 2016 ... more sensitively detects cancers susceptible to PARP inhibitors ... circulating tumor cells (CTCs). The new test has ... HRD-targeted therapeutics in multiple cancer types. ... targeting DNA damage response pathways, including PARP, ATM, ...
(Date:6/23/2016)... 2016   Boston Biomedical , an industry ... to target cancer stemness pathways, announced that its ... Drug Designation from the U.S. Food and Drug ... including gastroesophageal junction (GEJ) cancer. Napabucasin is an ... cancer stemness pathways by targeting STAT3, and is ...
(Date:6/23/2016)... Prostate Cancer Foundation (PCF) is pleased to announce 24 new Young Investigator ... Members of the Class of 2016 were selected from a pool of 128 ... About the Class of 2016 PCF Young Investigators ... ... ...
Breaking Biology Technology:
Cached News: