HOME >> BIOLOGY >> NEWS
Enzyme discovery to benefit homeland security, industry

RICHLAND, Wash. - Scientists at the Department of Energy's Pacific Northwest National Laboratory have successfully immobilized enzymes while simultaneously enhancing their activity and stability, opening up new possibilities for using tailored nanoporous materials. The findings, reported in an upcoming issue of the Journal of the American Chemical Society (available online Aug. 28), could enable the development of novel sensor and decontamination systems for homeland security, environmental protection and energy generation as well as new industrial chemicals and separations.

"For decades, scientists have been searching for ways to immobilize soluble enzymes with a variety of solid materials. But the results have been disappointing because only small amounts of the immobilized enzymes show any biological activity," said Eric Ackerman, PNNL molecular biologist. "For the first time, we have immobilized an enzyme at high concentrations in a way that actually enhances its stability and activity."

In lab tests, PNNL scientists nearly doubled the activity levels of an enzyme called organophosphorus hydrolase, known for its potential for biosensing and decontaminating poisonous agents.

"By using different highly active and stable immobilized enzymes, we could potentially make enzymatic systems to inactivate certain chemicals or bioweapons, thus serving as a protective barrier in air filtration systems," said Ackerman.

Fabrication of a more stable and active enzyme delivery method could potentially benefit other industries as well. For example, food processing companies use natural enzymes to produce items such as cheese, beer and soft drinks, while the biomedical industry uses them to manufacture drugs. Enzymes, which are proteins found in all organisms from humans to viruses, function as catalysts. Increasing an enzyme's activity - while enhancing enzyme stability - could facilitate more efficient chemical processes.

To achieve enhanced
'"/>

Contact: Staci Maloof
staci.maloof@pnl.gov
509-372-6313
DOE/Pacific Northwest National Laboratory
12-Sep-2002


Page: 1 2

Related biology news :

1. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
2. Enzyme activation appears key in helping internal clock tell night from day
3. Enzyme fully degrades mad cow disease prion
4. Enzyme revealed that is key to funguss ability to breach immune system
5. Enzyme discovery sheds light on causes of rare disease, cancer
6. Enzyme could overcome industrial bleaching waste problems
7. Enzyme controls good cholesterol
8. Enzyme could aid cancer fight
9. Enzyme once thought harmful to Alzheimers patients now appears key to future treatment
10. Enzyme mimetic reduces tissue damage in colitis animal study
11. Enzyme studies at Brookhaven Lab may lead to new antiviral agents

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Enzyme discovery benefit homeland security industry

(Date:7/22/2014)... fires started on July 14, 2014, by lightning from a ... Complex consists of four fires: Stokes Fire, Gold Hikes Fire, ... Gold Hikes fires are now one larger fire. The fires ... is currently over 243,000 acres in size. The present ... fire danger. Public and firefighter safety is the priority on ...
(Date:7/22/2014)... on the horizon. Bacteria that produce a therapeutic ... resistance and other adverse effects of a high-fat ... "Of course it,s hard to speculate from mouse ... assistant professor of Pharmacology. "But essentially we,ve prevented ... mice, even though they,re eating a high-fat diet.", ...
(Date:7/22/2014)... Rochelle, NY -- Stem cells offer much promise for ... approaches stem cell survival is poor, limiting their effectiveness. ... the survival and optimize their therapeutic function after transplantation, ... Open Access , a peer-reviewed journal from Mary Ann ... the BioResearch Open Access website . ...
Breaking Biology News(10 mins):Vanderbilt study shows therapeutic bacteria prevent obesity in mice 2
(Date:7/22/2014)... SHENZHEN , Kina, 22. juli 2014 /PRNewswire/ ... et datterselskab af BGI, verdens største genomics-organisation, annoncerede ... exome-sekvenseringstjeneste baseret på Complete Genomics brancheførende platform. ... for at levere patenterede sekvenseringsteknologier med 99,999 % ... blev købt af BGI i 2013. Mere end ...
(Date:7/22/2014)... en SHENZHEN, China , ... LTD, (BGI Tech), een dochtermaatschappij van BGI, ,s wereld ... wereldwijde introductie aan van een nieuwe service ten behoeve ... meest geavanceerde platform van Complete Genomics. ... binnen de sector in hoog aanzien staat vanwege de ...
(Date:7/22/2014)... 2014 Hussey Copper , a leader ... antimicrobial copper announces Pullman Regional Hospital,s conversion of more ... solid touch surface, at a nominal cost.  This reasonably ... and other bacteria within 2 hours of exposure 1 ... and infectious diseases in its facilities. Pullman ...
(Date:7/22/2014)... , July 22, 2014  Semler Scientific, Inc. ... medical risk assessment company that develops patented products ... evaluating chronic diseases, today announced that it will ... open of U.S. financial markets on July 25, 2014. Doug ... host a conference call at 11 a.m. EDT, July 25, ...
Breaking Biology Technology:BGI Tech lancerer Human Whole Exome-sekvenseringstjeneste på Complete Genomics avancerede platform 2BGI Tech introduceert service op gebied van hele menselijke exoomsequencing op geavanceerd Complete Genomics-platform 2Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 2Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 3Semler to Report Second Quarter 2014 Financial Results and Host Conference Call on July 25, 2014 2
Cached News: