HOME >> BIOLOGY >> NEWS
Enzyme studies at Brookhaven Lab may lead to new antiviral agents

UPTON, NY -- Three new enzyme studies at the U.S. Department of Energy's Brookhaven National Laboratory have yielded a new strategy for blocking infection by human adenovirus. The findings, reported in the October, November, and December issues of the journal Biochemistry, have already been used to design novel antiviral drugs.

Adenoviruses cause a number of acute infections, including respiratory and gastrointestinal infections, and also conjunctivitis. In patients with compromised immune systems, such as those infected with human immunodeficiency virus (HIV), an opportunistic adenovirus infection is frequently deadly. "Our new antiviral drugs are expected not only to inhibit adenovirus, but might also be effective against other organisms that use the same enzyme -- including Chlamydia, one of the most prevalent sexually transmitted diseases, and Yersinia pestis, the organism that causes the black plague," said Walter Mangel, the lead scientist on the studies.

During infection, these viruses make an enzyme called a protease, which cleaves or degrades other proteins. The protease is used by the virus to complete the maturation of newly synthesized virus particles. To explain this process, Mangel uses the example of building a cathedral around internal scaffolding. Once the cathedral is in place, the last step is to remove the scaffolding. "Similarly," says Mangel, "adenovirus particles are built with scaffolding protein inside. Once the virus particle is formed, the protease becomes activated and cleaves the scaffolding to render the virus particle infectious."

The three recent Brookhaven studies reveal that the protease is initially synthesized in an inactive form. The inactive enzyme binds to the viral DNA to become partially activated.

"Such activation of a protease by DNA has never been seen before," Mangel said.

The partially activated enzyme then cleaves out a cofactor (a protein fragment), which binds to the protease to
'"/>

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
4-Dec-2001


Page: 1 2 3

Related biology news :

1. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
2. Enzyme activation appears key in helping internal clock tell night from day
3. Enzyme fully degrades mad cow disease prion
4. Enzyme revealed that is key to funguss ability to breach immune system
5. Enzyme discovery sheds light on causes of rare disease, cancer
6. Enzyme could overcome industrial bleaching waste problems
7. Enzyme controls good cholesterol
8. Enzyme discovery to benefit homeland security, industry
9. Enzyme could aid cancer fight
10. Enzyme once thought harmful to Alzheimers patients now appears key to future treatment
11. Enzyme mimetic reduces tissue damage in colitis animal study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/14/2019)... ... 14, 2019 , ... FileWave, the multi-platform endpoint management solution ... launch of its North American channel partner program. Resellers can sign on in ... add FileWave’s industry-leading solutions to their portfolios immediately. With a newly signed distribution ...
(Date:3/12/2019)... ... March 12, 2019 , ... FEITIAN Technologies ... all-in-one smart cards, announced today the launch of two new payment card types ... Dynamic CVV Payment cards. These advanced technologies will help all elements of the ...
(Date:3/9/2019)... British Columbia (PRWEB) , ... March 07, 2019 ... ... specializing in manufacturing neurological and cellular stress research tools today announced the publication ... antibody for Parkinson’s Disease treatment. The antibody, still at a pre-clinical stage of ...
Breaking Biology News(10 mins):
(Date:3/14/2019)... ... March 14, 2019 , ... ... solution for preclinical research organizations. It is a low code, GDPR/21 CFR ... and facilities, innovative technology-driven automated data capture and seamless data and information ...
(Date:3/11/2019)... ... March 11, 2019 , ... In this live webinar, the ... your clinical trial efficiency and experience. Participants will learn how to use the information ... to ensure that the simple or complex randomization scheme is properly designed and set ...
(Date:3/9/2019)... , ... March 08, 2019 ... ... unbiased college rankings and higher education planning, announced the release of their ... top programs in the nation based on curriculum quality, program flexibility, affordability, ...
(Date:3/4/2019)... , ... March 04, 2019 , ... Stay on top of current hot topics through ... to all webinars is free, so be sure to register today to save your place! ... to see our upcoming webinars: , CLINICAL TRIALS, , March 20 ...
Breaking Biology Technology:
Cached News: