HOME >> BIOLOGY >> NEWS
Errant nerve cells risk a clockwork death

October 21, 1999--Fetal nerve cells growing along the spinal cord literally race against the clock to create connections within the developing nervous system. Newly published studies by investigators at the Howard Hughes Medical Institute (HHMI) at the University of California, San Francisco (UCSF), show that growing neurons must reach a specific intermediate destination by a certain time or risk not receiving life-sustaining chemical signals from specialized spinal cord tissue.

According to Marc Tessier-Lavigne, an HHMI investigator at UCSF, the discovery likely reveals a new fail-safe mechanism that ensures proper wiring of the nervous system. This checkpoint allows the burgeoning nervous system to winnow wayward neurons whose meanderings could cause dangerous miswiring of neural circuitry.

Tessier-Lavigne and former postdoctoral fellow Hao Wang, who is now a scientist at the Merck Research Laboratories, reported their discovery in the October 21, 1999, issue of Nature.

The new mechanism for intermediate control of neural wiring is different from, albeit complementary to, the well-known "final target-derived neurotrophic system," which governs the survival of neurons once they reach their final destination in the nervous system and kills off neurons that inadvertently reach the wrong target. The newly described "intermediate control" system functions solely to ensure accuracy in neural connections.

"In the traditional, final target-derived neurotrophic system," Tessier-Lavigne explained, "the long cable-like axons of nerve cells must compete for limited life-giving chemical signals known as neurotrophins when they reach their final target." Competition for limited amounts of neurotrophins at a target cell kills off excess nerve cells, leaving only the proper population of neurons necessary for wiring a given neural circuit.

"We speculate that
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
20-Oct-1999


Page: 1 2 3

Related biology news :

1. Errant stem cells may account for symptoms of schizophrenia
2. Casanova or caveman: Scientists isolate nerve cells that choreograph male flys courtship behavior
3. Protein key to trafficking in nerve terminals
4. Scientists discover key step in the development of nerve cells controlling autonomic functions
5. Severe depression associated with greater number of nerve cells in thalamus region of brain
6. UNC scientists discover molecular pathway leading to nerve growth and regeneration
7. Device that rapidly detects nerve agents named one of greatest army inventions for 2003
8. Turning bone into nerve
9. Protein engineered to detect nerve gas
10. Biologists discover nerve activity, not just genetics controls kinds of neurotransmitters produced
11. Genetic basis of hereditary nerve disorder revealed

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: