HOME >> BIOLOGY >> NEWS
Errant nerve cells risk a clockwork death

October 21, 1999--Fetal nerve cells growing along the spinal cord literally race against the clock to create connections within the developing nervous system. Newly published studies by investigators at the Howard Hughes Medical Institute (HHMI) at the University of California, San Francisco (UCSF), show that growing neurons must reach a specific intermediate destination by a certain time or risk not receiving life-sustaining chemical signals from specialized spinal cord tissue.

According to Marc Tessier-Lavigne, an HHMI investigator at UCSF, the discovery likely reveals a new fail-safe mechanism that ensures proper wiring of the nervous system. This checkpoint allows the burgeoning nervous system to winnow wayward neurons whose meanderings could cause dangerous miswiring of neural circuitry.

Tessier-Lavigne and former postdoctoral fellow Hao Wang, who is now a scientist at the Merck Research Laboratories, reported their discovery in the October 21, 1999, issue of Nature.

The new mechanism for intermediate control of neural wiring is different from, albeit complementary to, the well-known "final target-derived neurotrophic system," which governs the survival of neurons once they reach their final destination in the nervous system and kills off neurons that inadvertently reach the wrong target. The newly described "intermediate control" system functions solely to ensure accuracy in neural connections.

"In the traditional, final target-derived neurotrophic system," Tessier-Lavigne explained, "the long cable-like axons of nerve cells must compete for limited life-giving chemical signals known as neurotrophins when they reach their final target." Competition for limited amounts of neurotrophins at a target cell kills off excess nerve cells, leaving only the proper population of neurons necessary for wiring a given neural circuit.

"We speculate that
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
20-Oct-1999


Page: 1 2 3

Related biology news :

1. Errant stem cells may account for symptoms of schizophrenia
2. Casanova or caveman: Scientists isolate nerve cells that choreograph male flys courtship behavior
3. Protein key to trafficking in nerve terminals
4. Scientists discover key step in the development of nerve cells controlling autonomic functions
5. Severe depression associated with greater number of nerve cells in thalamus region of brain
6. UNC scientists discover molecular pathway leading to nerve growth and regeneration
7. Device that rapidly detects nerve agents named one of greatest army inventions for 2003
8. Turning bone into nerve
9. Protein engineered to detect nerve gas
10. Biologists discover nerve activity, not just genetics controls kinds of neurotransmitters produced
11. Genetic basis of hereditary nerve disorder revealed

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/4/2019)... ... December 04, 2019 , ... Cartessa ... Subnovii Advanced Plasma Technology for U.S. dermatologists, plastic surgeons and licensed aesthetic ... plasma to employ LF technology – low frequency plus a patented wavelength and ...
(Date:11/27/2019)... (PRWEB) , ... November 26, 2019 , ... Personalized ... event put on by the Arthritis Foundation and hosted by Dr. Steven Sampson and ... event, which took place on October 23, 2019, highlighted the ongoing efforts to promote ...
(Date:11/19/2019)... ... November 19, 2019 , ... Project Lifeline – a community ... Foundation to address substance use disorder (SUD) – will take center stage ... led to the program’s effectiveness in preventing and treating opioid abuse in Blair County, ...
Breaking Biology News(10 mins):
(Date:11/27/2019)... , ... November 25, 2019 , ... ... has announced the company’s first robotic-assisted and navigated surgery in the UK. The ... (NHS) by acclaimed spine surgeons, Dr. Syed Aftab and Dr. Alexander Montgomery. The ...
(Date:11/22/2019)... ... November 21, 2019 , ... Lajollacooks4u is preparing for another busy holiday ... already scheduled several of its popular cooking classes and team-building events, but the company ... company’s Holiday Parties have been a favorite for companies of all sizes since 2008. ...
(Date:11/19/2019)... ... November 19, 2019 , ... Supercomputing Conference ... learning infrastructure solutions for Autonomous Vehicle , Medical Imaging, and Natural Language ... systems with the Graphcore Poplar® software stack as part of its bare-metal cloud ...
(Date:11/12/2019)... , ... November 12, 2019 ... ... enterprise software solutions for biopharmaceutical R&D, today announced that Immatics Biotechnologies ... adopted Genedata Biologics® to streamline their R&D operations related to ...
Breaking Biology Technology:
Cached News: