Estrogen lifts mood in perimenopause

8/25/00 -- Women who suffer depression as they enter the early stages of menopause (perimenopause) may find estrogen to be an alternative to traditional antidepressants, suggest National Institute of Mental Health (NIMH) researchers. The efficacy of the female hormone was comparable to that usually reported with antidepressants in the first controlled study of its direct effects on mood in perimenopausal women meeting standardized criteria for depression. Drs. Peter Schmidt, David Rubinow of the NIMH Behavioral Endocrinology Branch, and colleagues, report on the findings of this preliminary study in the August 2000 American Journal of Obstetrics and Gynecology.

Estrogen levels, body thermostats and mood often fluctuate in the perimenopause. But only a minority of women become clinically depressed. Although researchers had long suspected that estrogen might lift mood in such women, controlled studies were lacking. Additionally, they hadn't ruled out the possibility that any antidepressant effect could be secondary to the hormone's known ability to reduce hot flushes. The night sweats, experienced by most perimenopausal women, often disturb sleep and may worsen mood, thus confounding assessment of the hormone's antidepressant properties. Might estrogen simply afford a good night's sleep?

To find out, Schmidt and Rubinow studied 34 women, ages 44-55, who experienced onset of depression coinciding with perimenopause, as confirmed by hormone measures and standardized diagnostic interviews. In controlled, randomized fashion, the women received either estrogen or placebo for 3-6 weeks. Using standardized symptom rating scales and structured interviews, the researchers confirmed that estrogen significantly boosted mood in 80 percent of the depressed women, independent of hot flushes. This level of relief, and the time required to achieve a therapeutic effect, about 3 weeks, are comparable to that seen with antidepressant drugs. Only 20% of the women res

Contact: Jules Asher
NIH/National Institute of Mental Health

Page: 1 2

Related biology news :

1. Estrogen promotes gender differences in brains response to stress
2. Estrogen receptor-a disruption and vasodilation in coronary arteries
3. Estrogen improves short term memory and oral reading in midlife postmenopausal women
4. Estrogen found as link between obesity and breast cancer in postmenopausal women
5. Estrogens as antioxidants reducing heart disease in younger postmenopausal women
6. Estrogen patch compared to pill minimizes cardiovascular risk factor in postmenopausal women
7. Estrogen and personality in women
8. Estrogen linked to more efficient regulation of a womans heartbeat
9. Estrogen may protect against breast cancer
10. Estrogen combined with calcium and vitamin D may prevent tooth loss
11. Estrogen found in soy stimulates human breast-cancer cells in mice

Post Your Comments:

(Date:8/26/2020)... ... , ... Modality Solutions, a biopharmaceutical cold chain validation engineering firm, ... list is the most prestigious ranking of the nation’s fastest-growing private companies. Modality Solutions ... reported three-year revenue growth of 71 percent. , The Inc. 5000 list represents ...
(Date:8/21/2020)... ... August 20, 2020 , ... NDA ... , a Clinical Operations executive with expertise in clinical trial planning and feasibility, ... as an Expert Consultant. Throughout his career, Mr. Movahhed has helped design and ...
(Date:8/5/2020)... ... ... Regenative Labs has received approval from the Centers for Medicare & Medicaid ... Wharton’s jelly allografts to be assigned a Q code and be approved for application ... jelly allograft product to be recognized as a 361 HCT/P by CMS regulated under ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... Colo. (PRWEB) , ... June ... ... of expert tissue data insights, today announced that the launch of a ... results along with data about the tumor microenvironment (TME). , “Flagship’s TissueInsight ...
(Date:6/28/2020)... ... June 25, 2020 , ... With the COVID-19 pandemic ... drug treatment. In an effort to better understand the cellular responses to COVID-19, ... imaging dataset portraying therapeutic compound effects from over 1,600 approved and referenced molecules ...
(Date:6/28/2020)... ... June 26, 2020 , ... The Security Industry Association ... strong opposition to the recently introduced bicameral Facial Recognition and Biometric Technology ... federal use of nearly all biometric and related image analytics technologies, incorrectly labeling ...
(Date:6/23/2020)... ... June 23, 2020 , ... DeCurtis Corporation, the premier ... that Derek Fournier has been appointed CEO and President. Founder and former CEO, ... , “DeCurtis Corporation has been on an incredible journey for the last ...
Breaking Biology Technology:
Cached News: