HOME >> BIOLOGY >> NEWS
Estrogen may protect against cocaine-induced brain dysfunction

, Pittsburgh, Pa.

Methodology
Lead researcher Marc Kaufman and his colleagues first established the rate of blood flow to the brain in male and female occasional cocaine users. An intravenous dose of cocaine (0.4 mg/kg) was administered to nine men and 13 women. Men were studied once while women were examined during different phases of their menstrual cycle phases (days 3-8, follicular phase and 18-24, leutial phase) after the beginning of menstruation.

Reduction in blood flow to the brain was measured with Dynamic Susceptibility Contrast functional magnetic resonance imaging (MRI), which uses a magnetic resonance contrast agent to detect changes in blood flow.

Results
In the follicular phase, when estrogen levels are high and progesterone levels are low, cocaine did not alter the amount of blood in the brain. By contrast, a 10 percent reduction in blood was found in women during their luteal menstrual cycle phase, when progesterone levels rise; male subjects incurred a 20 percent loss. These findings suggest that cocaines effects on blood vessels in the brain differ as a function of sex and menstrual cycle phase, and imply that progesterone in women and testosterone in men may enhance cocaine-induced vasoconstriction, while estrogen in women may blunt cocaines vascular effects.

Significance of Findings
Previous studies have asserted that chronic cocaine users are found to be more prone to strokes than non-abusers of the drug. Abusers have also been found to suffer damage to electrical activity of the brain, which may be secondary to reduced blood flow.

Estrogen, or a synthetic estrogen-like compound, could be helpful in treating the two percent of Americans needing relief from cocaine addiction, by reducing damage caused to the brain by the addictive drug. Such benefits could extend beyond drug using populations. For example, treatments that improve brain blood flow might al
'"/>

Contact: Donna Krupa
703-967-2751
American Physiological Society
18-Oct-2001


Page: 1 2 3

Related biology news :

1. Estrogen promotes gender differences in brains response to stress
2. Estrogen receptor-a disruption and vasodilation in coronary arteries
3. Estrogen improves short term memory and oral reading in midlife postmenopausal women
4. Estrogen found as link between obesity and breast cancer in postmenopausal women
5. Estrogens as antioxidants reducing heart disease in younger postmenopausal women
6. Estrogen patch compared to pill minimizes cardiovascular risk factor in postmenopausal women
7. Estrogen and personality in women
8. Estrogen linked to more efficient regulation of a womans heartbeat
9. Estrogen may protect against breast cancer
10. Estrogen combined with calcium and vitamin D may prevent tooth loss
11. Estrogen found in soy stimulates human breast-cancer cells in mice

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Estrogen may protect against cocaine induced brain dysfunction

(Date:11/5/2014)... Brazil -Individuals show great diversity in their ability to ... females greatly differ in their perceptual evaluation of odors, ... tests. , Sex differences in olfactory detection ... may be connected to one,s perception of smell, which ... women,s olfactory superiority has been suggested to be cognitive ...
(Date:11/4/2014)... Temple University School of Medicine announced today that ... initiative funded by the Bill & Melinda Gates ... Obstetrics, Gynecology and Reproductive Sciences; and Vice Chair ... School of Medicine will pursue an innovative global ... Biomarkers to Assess Fetal Neurodevelopment.", Grand Challenges Explorations ...
(Date:11/4/2014)... November 4, 2014   ... growth   Fuel3D , a developer of ... funding round totaling $6.4 million (£4 million). This funding builds ... earlier this year and paves the way for the commercial ... The funding round was led by Chimera Partners and ...
Breaking Biology News(10 mins):The female nose always knows: Do women have more olfactory neurons? 2Temple University School of Medicine receives Grand Challenges Explorations grant 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3
(Date:11/26/2014)... 2014 On January, 14, 2015, ... Washington D.C. science community to the UMBC campus for ... by the Protein Society, will take place from 9 ... 312. Through discussion, presentations and workshops, the free ... proteins, their role in the industry and the future ...
(Date:11/26/2014)... Whitehouse Laboratories is pleased to ... County (New Jersey) Chamber of Commerce as a ... organization in the North Jersey area, offers Whitehouse ... key clients in the pharmaceutical and biotechnology areas ... Membership enables Whitehouse Laboratories a higher level of ...
(Date:11/26/2014)... 2014 Continuing its award-winning streak, Nerium ... prestigious MarCom Awards for outstanding creative achievement by its ... MarCom Award, the organization’s top honor, in the Branding ... held in April of this year. The event showcased ... Additionally, Nerium was awarded a Gold MarCom Award in ...
(Date:11/26/2014)... West Chester, OH (PRWEB) November 25, 2014 ... International Holdings, has joined the Graphel Carbon Products team ... experience in sales, marketing, and customer service for the ... to add Miles to our team,” stated Dave Trinkley, ... Products. “His wide range of experience in the ...
Breaking Biology Technology:Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 3Nerium International™ Wins One Platinum, Two Gold MarCom Awards 2Miles Holder Joins Graphel Corporation as Sales/Marketing Manager 2
Cached News: