HOME >> BIOLOGY >> NEWS
Estrogen may protect against cocaine-induced brain dysfunction

, Pittsburgh, Pa.

Methodology
Lead researcher Marc Kaufman and his colleagues first established the rate of blood flow to the brain in male and female occasional cocaine users. An intravenous dose of cocaine (0.4 mg/kg) was administered to nine men and 13 women. Men were studied once while women were examined during different phases of their menstrual cycle phases (days 3-8, follicular phase and 18-24, leutial phase) after the beginning of menstruation.

Reduction in blood flow to the brain was measured with Dynamic Susceptibility Contrast functional magnetic resonance imaging (MRI), which uses a magnetic resonance contrast agent to detect changes in blood flow.

Results
In the follicular phase, when estrogen levels are high and progesterone levels are low, cocaine did not alter the amount of blood in the brain. By contrast, a 10 percent reduction in blood was found in women during their luteal menstrual cycle phase, when progesterone levels rise; male subjects incurred a 20 percent loss. These findings suggest that cocaines effects on blood vessels in the brain differ as a function of sex and menstrual cycle phase, and imply that progesterone in women and testosterone in men may enhance cocaine-induced vasoconstriction, while estrogen in women may blunt cocaines vascular effects.

Significance of Findings
Previous studies have asserted that chronic cocaine users are found to be more prone to strokes than non-abusers of the drug. Abusers have also been found to suffer damage to electrical activity of the brain, which may be secondary to reduced blood flow.

Estrogen, or a synthetic estrogen-like compound, could be helpful in treating the two percent of Americans needing relief from cocaine addiction, by reducing damage caused to the brain by the addictive drug. Such benefits could extend beyond drug using populations. For example, treatments that improve brain blood flow might al
'"/>

Contact: Donna Krupa
703-967-2751
American Physiological Society
18-Oct-2001


Page: 1 2 3

Related biology news :

1. Estrogen promotes gender differences in brains response to stress
2. Estrogen receptor-a disruption and vasodilation in coronary arteries
3. Estrogen improves short term memory and oral reading in midlife postmenopausal women
4. Estrogen found as link between obesity and breast cancer in postmenopausal women
5. Estrogens as antioxidants reducing heart disease in younger postmenopausal women
6. Estrogen patch compared to pill minimizes cardiovascular risk factor in postmenopausal women
7. Estrogen and personality in women
8. Estrogen linked to more efficient regulation of a womans heartbeat
9. Estrogen may protect against breast cancer
10. Estrogen combined with calcium and vitamin D may prevent tooth loss
11. Estrogen found in soy stimulates human breast-cancer cells in mice

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Estrogen may protect against cocaine induced brain dysfunction

(Date:12/24/2014)... in December 2014, the 1U™ app has helped ... remember their usernames and passwords through replacing the antiquated system ... people who have struggled to remember usernames and passwords, ... on redefining identity, announced today that it is offering the ...
(Date:12/22/2014)... Dec. 22, 2014 Research and Markets ... the "The Global Watermarking and Fingerprinting Markets" ... http://photos.prnewswire.com/prnh/20130307/600769 This insight ... watermarking and fingerprinting markets. Watermarking aims to control ...
(Date:12/19/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ) ... Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology ... http://photos.prnewswire.com/prnh/20130307/600769 Following the acquisition ... reading feature with the iPhone 5S. It is currently ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3The Global Watermarking and Fingerprinting Markets 2iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2
(Date:1/22/2015)... 22, 2015  Transwestern | RBJ today announces the firm brokered ... for Shire a leading biopharmaceutical company, at Two Ledgemont Center ... Robert Richards , president, and Brian Cohen , ... entire five-floor building at 95 Hayden Ave. Photo ...
(Date:1/22/2015)... CO / Rootstown, OH (PRWEB) January 22, 2015 ... detection platform, announced today that it has received AOAC-PTM Certifications ... O45, O1O3, O111, O121, and O145; collectively referred to as ... coli) O157, at 1 colony forming unit (cfu) per 325 ...
(Date:1/22/2015)... January 22, 2015 Controlled Substance Compliance ... which helps companies check the legal requirements around using ... to China. , As their international operations expand ... adopting software solutions built as a result of the ...
(Date:1/22/2015)... , Jan. 22, 2015   Cypher Genomics, ... Sequenom, Inc. (NASDAQ: SQNM ), the ... agreement for next generation noninvasive prenatal tests (NIPT). ... interpretation technology, called Mantis™, to advance analysis of ...
Breaking Biology Technology:Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Global Compliance Service for Controlled Substances to Expand to China 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4
Cached News: