HOME >> BIOLOGY >> NEWS
Estrogens as antioxidants reducing heart disease in younger postmenopausal women

HRT could be used to protect younger postmenopausal women from heart disease. An article published in the journal Lipids in Health and Disease shows that estrogens commonly used in HRT reduce the build up of harmful oxidised lipoproteins, which can lead to heart disease, by acting as antioxidants.

It is well known that high-density lipoproteins (HDL) protect against heart disease while low-density lipoproteins (LDL) promote it. However, recent research has shown that the relationship is not that simple. The effectiveness of both types of lipoprotein change when they are oxidised by free radicals highly reactive by-products of metabolism. If LDL becomes oxidised its ability to cause heart disease increases. If HDL becomes oxidised its ability to protect against heart disease is lessened.

Researchers from St. Michael's Hospital, part of the University of Toronto, have shown that estrogens can act as antioxidants, which neutralise free radicals, and hence protect HDL from oxidation. In addition, high levels of HDL are able to protect LDL from oxidation, and this ability is strongly enhanced when estrogens are present.

Dr Bhagu Bhavnani's team, who carried out the research, write, "The inhibition of HDL oxidation and the enhancement provided by estrogens toward the inhibition of LDL oxidation may be another way in which estrogens reduce the risk of coronary heart disease in healthy young postmenopausal women."

Although recent randomised control trials have shown that HRT in older women may not reduce the incidence of coronary heart disease, Dr. Bhavnani believes that this is not the whole story. Although his team carried out experiments in test tubes rather than in human subjects they saw that estrogen had beneficial effects at concentrations lower than those found in women on HRT. He urges that, "randomised control trials using lower doses of HRT, different estrogens and progestins, and in younger postmenopausal women, from 50
'"/>

Contact: Gemma Bradley
press@biomedcentral.com
44-207-323-0323
BioMed Central
4-Jul-2003


Page: 1 2

Related biology news :

1. New antioxidants are 100 times more effective than vitamin E
2. Hot cocoa tops red wine and tea in antioxidants; may be healthier choice
3. Research may take the anti out of antioxidants
4. Researchers call herbs rich source of healthy antioxidants; oregano ranks highest
5. Holiday fruit ranks number one in antioxidants
6. UF researcher: antioxidants play a role in deadly malnutrition disease
7. Diet of antioxidants and oils improves lung disorder, study shows
8. Medication reconciliation, pharmacist involvement vital to reducing medication errors, study finds
9. New compound highly efficacious at reducing human tumour growth
10. A new approach holds promise for reducing cocaine craving
11. Site of US Open at Bethpage is reducing pesticide use

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/27/2019)... , ... April 26, 2019 , ... ... Plan Competition on Thursday, April 25. More than 30 student venture teams, representing ... prizes totaling more than $75,000. , The top five teams in the ...
(Date:4/25/2019)... ... April 23, 2019 , ... In recent years the neurocognitive ... However, in many cases the magnitude of these deficits and the long-term impact ... given neurocognitive effects may impact developmental trajectories, and patients are often so unwell ...
(Date:4/25/2019)... ... April 24, 2019 , ... Noblis, Inc., a leading provider ... 10,191,929, “Systems and Methods for SNP Analysis and Genome Sequencing.” Noblis’ new system ... of advanced bioinformatic analyses, including SNP calling, metagenomic analysis, and conserved and signature ...
Breaking Biology News(10 mins):
(Date:4/16/2019)... ... 2019 , ... On April 24th, the Federal Laboratory Consortium ... for Environmental Health Research (USACEHR), with an award for their cooperative effort in ... company located at the Frederick Innovative Technology Center, Inc. (FITCI) on Metropolitan Court, ...
(Date:4/10/2019)... FREDERICK, Md. (PRWEB) , ... ... ... and GenCure, both regenerative medicine manufacturing technology leaders, have locked into multiple ... than ever before. Companies across the regenerative medicine industry, ranging from synthetic ...
(Date:4/9/2019)... ... 2019 , ... The American Society of Gene & Cell Therapy (ASGCT) ... a new addition to the presidential line of succession, at the 22nd Annual ... leadership team for a three-year term (2019-2021). , All five incoming members of the ...
(Date:4/4/2019)... ... April 02, 2019 , ... Biomeme, ... be releasing it’s latest field-ready solution for performing PCR, RT-PCR, qPCR, and Isothermal ... pays homage to Rosland Franklin, an English chemist and X-ray crystallographer who made ...
Breaking Biology Technology:
Cached News: