HOME >> BIOLOGY >> NEWS
Even the Immune System works with Pincers

Max-Planck-Scientists decipher central protein complex in the human immune system / Relevance for future therapies in allergies, autoimmune diseases and transplantation medicine

A key building block of the human immune system was identified up to the atomic detail using the method of x-ray crystallography by scientists of the Max-Planck-Institute for Biochemistry in Martinsried/Germany (Nature, 20. July 2000, S. 267-273). The protein complex, a mediator between the soluble and cellular compounds of the immune components in the blood, consists of an antibody and its respective receptor. Their dialogue in the immune system ensures that pathogenic germs which were previously labeled with antibodies are removed by receptor-equipped immune cells, eg macrophages. The identification of the structure and of the exact location of the interaction site between both proteins opens new possibilities not only for the therapy of diseases like allergies or autoimmune diseases, but also in the field of transplantation medicine.

The most important weapon in the defense of diseases in the human organism are Y-shaped antibodies, the so-called immunoglobulins (Ig). Many quintillions of antibodies with more than a trillion different specificities are found in the blood of the human body. These subdivide themselves - as within all mammals - into five different antibody types: IgM, IgG, IgA, IgD and IgE. Every class has its own particular characteristics that makes it possible to adopt a certain defense function. IgA for example, can be transported through the uppermost layer of the skin and is found in saliva, sweat and tears.

The well investigated immunoglobulin IgG is, with 80 percent, the most abundant antibody class in the circulation. It easily passes through walls of blood vessels or the placental barrier and confers, by this, passive immun
'"/>

Contact: Peter Sondermann
sonderma@biochem.mpg.de
49-89-85782701
Max-Planck-Gesellschaft
27-Jul-2000


Page: 1 2 3

Related biology news :

1. Immune systems attack dogs kept on genetic leash
2. Immune system drug may increase availability of liver transplants
3. Immune cells may help deliver cancer vaccines for children
4. Immune response depends on key molecule: Research
5. Applied Biosystems and Immune Tolerance Network announce immunology research agreement
6. Immune system component found common to both humans and worms
7. Immune cells SLAP internal signals together
8. Immune co-stimulation and the Kaposis virus
9. Immune system helps prevent tumors after all
10. Immune system chemical may predict worsening of coronary heart disease in women
11. UWs new Cell Systems Initiative welcomes Immunex collaboration

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/6/2016)... Dec. 6, 2016 Securus Technologies, a ... solutions for public safety, investigation, corrections and monitoring, ... today a five (5) year funding commitment by ... expand the rehabilitation and reentry support to more ... Established in 2004, the Prison Entrepreneurship Program (PEP) ...
(Date:12/2/2016)... , Dec. 1, 2016   SoftServe , ... BioLock , an electrocardiogram (ECG) biosensor analysis ... a key IoT asset. The smart system ensures ... vehicle,s steering wheel and mobile devices to easily ... As vehicle technology advances, so too ...
(Date:11/29/2016)... BOSTON , Nov. 29, 2016 BioDirection, ... rapid point-of-care products for the objective detection of concussion ... the company has successfully completed a meeting with the ... company,s Tbit™ blood test Pre-Submission Package. During the meeting ... Tbit™ system as a precursor to commencement of a ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... ... December 08, 2016 , ... From ... innovation is taking over sports. On Thursday, December 15th a panel of entrepreneurs, ... disrupting the playing field at a Smart Talk session. Smart Talk will run ...
(Date:12/8/2016)... Dec. 8, 2016  Biotheranostics today announced that ... of the Breast Cancer Index (BCI) in identifying ... are most at-risk for disease recurrence and might ... from three studies advancing the understanding of the ... tumor biology and inform decisions related to patient ...
(Date:12/8/2016)... -- Eurofins announces the appointment of Sean Murray , National ... (ESI). Mr. Murray will bring valuable expertise to ... in leading international business teams. As the National Division Leader, he ... Eurofins, status as the global leader in bio-analytical testing services. ... , , ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... ... the FrontPanel SDK that provide essential device-to-computer interconnect using USB or PCI Express, ... require FrontPanel support. The FOMD-ACV-A4 is a small, thin, SODIMM-style module that fits ...
Breaking Biology Technology:
Cached News: