Evidence From Old Tumors Foretells Which New Breast Cancer Patients Will RequireAdditional...( unidentified critical changes needed fo...)

Evidence From Old Tumors Foretells Which New Breast Cancer Patients Will RequireAdditional Treatment

unidentified critical changes needed for tumor spread.

"Those patients with high MVC and low nm23 would be advised to have both radiation and chemotherapy following surgery," said Hellman. But for patients without a lot of tumor vessels, or even those who have some angiogenesis but still protective high nm23 levels, it might be quite reasonable to skip adjuvant chemotherapy and avoid its costs, inconvenience and discomfort. Finding better and better markers of who needs more therapy is a big step toward more rational treatment decisions."

Since breast cancer deaths result not from the original tumor but from its dissemination to distant sites, preventing metastasis, even for patients with limited risk, is a fundamental aspect of treatment, agree the authors. But "a worthwhile secondary goal is avoiding either unnecessary or insufficient treatment," notes Heimann, "and these markers, even when measured in archival, paraffin-embedded tissue, appear to provide excellent clues about who does and who doesn't need more therapy."

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Contact: John Easton
jeaston@mcis.bsd.uchicago.edu
773 702 6241
University of Chicago Medical Center
1-Jul-1998

Page: 1 2 3
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