HOME >> BIOLOGY >> NEWS
Evidence Mounts Against Maintstream Dogma In Embryology, Could Shed New Light On,,Neurological Defects

New work on zebrafish development is about to complicate a debate already brewing among embryologists. According to the mainstream dogma, the notochord, a rod-like structure that precedes the vertebral column in vertebrate embryos, signals neural cells to induce the formation of floor plate, a crucial row of cells that lies along the floor of the ventral brain and spinal cord. This belief has come under fire recently, as new data about floor plate development cast doubt on the authoritative role of the notochord.

A group of scientists at the Carnegie Institution of Washington, Vanderbilt University, and the National University of Singapore bring forth more evidence in opposition to the classic model with their report appearing in the September 10 Nature. The authors argue that the first steps in floor plate development occur earlier than was initially thought, in reaction to inducing factors other than those emitted by the notochord. The new data, based on studies of zebrafish mutants, may also shed light on certain neurological defects that affect humans as well as fish namely, holoprosencephaly. This syndrome, which can result in severe deformity and death, prevents the forebrain hemispheres from separating normally, in turn preventing the initial eye field from separating into two eyes during embryonic development.

The model

The mainstream model for patterning of the central nervous system was demonstrated in the 1980s and much supportive evidence has been obtained ever since. In this model, the notochord instructs neural tube precursor cells to differentiate into floor plate during the early stages of somitogenesis (i.e., the time of formation of somites, blocks of similar cells that differentiate into muscles, bone, and other tissues). The command arrives via a potent messenger protein, Sonic hedgehog. Once formed, the floor plate then induces motor neurons to develop on either side (motor neurons will ultimately relay
'"/>

Contact: Catherine Whittenburg
cwhittenburg@pst.ciw.edu
(202) 939-1121
Carnegie Institution
9-Sep-1998


Page: 1 2 3

Related biology news :

1. Evidence builds for potential new cancer drug target
2. Evidence for sympatric speciation by host shift in the sea
3. Evidence for the impact of climate change on deep-sea biodiversity
4. Evidence for fat hormone target in brain
5. Evidence of nanobacterial-like structures found in human calcified arteries and cardiac valves
6. Evidence shows the heart has stem cells able to regenerate muscle tissue lost to disease, wear
7. Evidence for orangutan culture
8. Evidence suggests that standard smallpox vaccine offers long-term immunity
9. Evidence that adults stem cells differentiate like embryonic stem cells published in Nature
10. When Shewanella meets goethite: Evidence found of recognition between animate and inanimate objects
11. Evidence links protein damage to Parkinsons

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" or ... independent Directors Mr. Robin D. Richards and Mr. ... the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer said," ... and benefiting from their considerable expertise as we move forward ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC ... announced that the United States Patent and Trademark Office ... broadly covers the linking of an iris image with ... transaction) and represents the company,s 45 th issued ... patent is very timely given the multi-modal biometric capabilities ...
(Date:3/29/2017)... CHICAGO , March 29, 2017  higi, the ... ecosystem in North America , today ... Partners and the acquisition of EveryMove. The new investment ... extensive set of tools to transform population health activities ... and lifestyle data. higi collects and secures ...
Breaking Biology News(10 mins):
(Date:7/26/2017)... ... July 26, 2017 , ... Joni Rutter, Director of ... of Health (NIH), will be one of the esteemed presenters at the 9th ... a multi-stakeholder discussion on the latest advancements in the precision and personalized medicine ...
(Date:7/25/2017)... , ... July 25, 2017 , ... ... enhance the microbiome and improve efficiency of livestock farming while reducing the use ... has licensed additional intellectual property from Cornell University. , These new proprietary ...
(Date:7/20/2017)... ... 2017 , ... The Arnold and Mabel Beckman Foundation has ... Engineering and Computer Science at the Massachusetts Institute of Technology, as its ... individual who has made and is continuing to make significant transformative breakthroughs in ...
(Date:7/20/2017)... ... July 20, 2017 , ... ... on digital pathology and artificial intelligence Tuesday, July 25, during the Association of ... from Johns Hopkins Medicine. , Baras, Associate Director of Pathology Informatics, will ...
Breaking Biology Technology:
Cached News: