HOME >> BIOLOGY >> NEWS
Evidence links protein damage to Parkinson's

Philadelphia -- New evidence links oxidative damage in a protein found in nerve cells to the development of degenerative diseases of the nervous system, such as Parkinson's and Alzheimer's. The first study to provide this evidence, conducted by University of Pennsylvania researchers, will be published in the November 3 issue of Science.

"The protein, called alpha-synuclein, is one of the building blocks of the brain lesions characteristic in patients with neurodegenerative diseases," says Dr. Virginia Lee, who is the John H. Ware III Professor in Alzheimer Research and co-director of the Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine at the University of Pennsylvania School of Medicine. Oxidative damage, she explains, normally occurs when the body's cells are overwhelmed by molecules that have changed because they have combined with nitrogen (nitration) or oxygen (oxidation).

Both types of oxidants damage lipids, nucleic acids, proteins, and other cellular components much like oxidation causes rust damage to metal in cars and buildings. This damage has been implicated in causing neurodegenerative disorders.

"We found that alpha-synuclein itself is a target of oxidative stress, specifically nitration, within these lesions, " says Lee. "This is the first time anybody has identified nitration on a specific protein."

Neurodegenerative diseases -- including Parkinson's, Alzheimer's, diffuse Lewy body disease, and multiple system atrophy -- are collectively called synucleinopathies. Most commonly they become symptomatic due to a deficiency of a specific neurotransmitter -- in the case of Parkinson's it is dopamine. When the neurons that produce these chemicals die or become impaired, which occurs with oxidation, the eventual results are tremors and sometimes dementia.

"Alpha-synuclein is found at the synapses of nerve cells," explains Lee. Earlier studies showed that two mutati
'"/>

Contact: Ellen O'Brien
ellen.obrien@uphs.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
1-Nov-2000


Page: 1 2

Related biology news :

1. Evidence builds for potential new cancer drug target
2. Evidence for sympatric speciation by host shift in the sea
3. Evidence for the impact of climate change on deep-sea biodiversity
4. Evidence for fat hormone target in brain
5. Evidence of nanobacterial-like structures found in human calcified arteries and cardiac valves
6. Evidence shows the heart has stem cells able to regenerate muscle tissue lost to disease, wear
7. Evidence for orangutan culture
8. Evidence suggests that standard smallpox vaccine offers long-term immunity
9. Evidence that adults stem cells differentiate like embryonic stem cells published in Nature
10. When Shewanella meets goethite: Evidence found of recognition between animate and inanimate objects
11. Evidence suggests food preservatives may help prevent cavities

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Evidence links protein damage Parkinson

(Date:10/16/2014)... synthesis of recent research findings to inform their management ... states. , The Ecology and Management of Moist ... of the Relevant Biophysical Science and Implications for Future ... U.S. Forest Service,s Pacific Northwest Research Station, is a ... synthesis of the large body of scientific information on ...
(Date:10/16/2014)... women experienced improvements in vaginal atrophy, with no ... after 12 weeks of daily 10 milligram (mg) ... supplement previously shown to help relieve certain menopause ... reported in a poster at the North American ... "These data documented improved vaginal epithelium, without significant ...
(Date:10/15/2014)... Life, is a non-traditional biophysics textbook and it describes ... a journey of discovery into biological systems and provides ... regulation. It is about how our genes make proteins ... billions of cells in an organism. It quantifies the ... which can be found on both large and small ...
Breaking Biology News(10 mins):New report synthesizes best available science on management of moist mixed-conifer forests 2S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2New book about life as seen from physics 2
(Date:10/18/2014)... The “Human Insulin Market- by Product Type, ... Human Insulin (Rapid Acting, Long Acting, Premixed)], by ... - Forecast to 2018” provides a detailed overview ... market trends, and strategies impacting the global human ... of the revenue and share analysis. , The ...
(Date:10/18/2014)... (PRWEB) October 18, 2014 The Asia-Pacific ... concerned market in Asia-Pacific with analysis and forecast of ... and is expected to reach $51,362.6 million by 2018, ... , Browse through the TOC of the Asia-Pacific hardware ... in-depth analysis provided. This also provides a glimpse of ...
(Date:10/18/2014)... 18, 2014 According to a new ... Well Type - Global Trends & Forecasts up till ... billion in 2011. This value is expected to increase ... 2017, with 10% CAGR during the same period. North ... production market in terms of hydraulic horse power supplied ...
(Date:10/17/2014)... through the looking-glass to Wonderland, mirrors in the real ... including a new class of mirror that works like ... Optical Society,s (OSA) new high-impact journal Optica ... a new type of mirror that forgoes a familiar ... using an unusual magnetic property of a non-metallic metamaterial. ...
Breaking Biology Technology:Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 2Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 3Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 5The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 3Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 2Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 3Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 4Magnetic mirrors enable new technologies by reflecting light in uncanny ways 2Magnetic mirrors enable new technologies by reflecting light in uncanny ways 3Magnetic mirrors enable new technologies by reflecting light in uncanny ways 4
Cached News: