HOME >> BIOLOGY >> NEWS
Evolution boosted anti-cancer prowess of a primordial gene

Researchers at St. Jude Children's Research Hospital have looked back in evolutionary time and identified what may be a gene that was once only moderately effective in slowing down cellular reproduction, until it linked up with a more efficient set of genes to create a powerful anti-cancer response.

The gene, called Arf, was already known to have cancer-suppressing activity. Arf responds to cancer-causing environments by activating the well-known tumor suppressor gene, p53. In turn, p53 activates a battery of other genes to stop cell growth or, in extreme cases, to trigger cell death in response to a variety of harmful conditions, such as DNA damage or activation of oncogenes (cancer-causing genes). In fact, loss of Arf or p53 is a common event in many human cancers.

But the new results suggest that Arf plays a role far older in evolutionary terms than its more familiar job of stimulating p53 to prevent cancer. The St. Jude findings suggest that Arf originally evolved to slow the cell's metabolism and growth by limiting production of ribosomes. Ribosomes, made up of RNA (de-coded DNA) and proteins, guide the production of all other cellular proteins according to the genetic code. The new work shows that Arf interferes with production of the RNA components of ribosomes in order to exert some control of protein production and cell growth.

"About 80 percent of a cell's RNA is tied up in ribosomes," said Charles Sherr, M.D., Ph.D., a member of the Genetics & Tumor Cell Biology Department at St. Jude and a Howard Hughes Medical Institute investigator. "In fact, producing ribosomes is practically what cells do for a living. It's their major energy-consuming activity. So it makes sense that any limitation on ribosome production would slow cell growth."

Sherr's team believes that Arf counteracts excessive growth-promoting stimuli by interfering with ribosome production. But inhibiting ribosomal production isn't a particularly efficient way to control
'"/>

Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
3-Mar-2003


Page: 1 2

Related biology news :

1. Evolution of whale hearing unfolds in fossil record
2. Evolutions mirror in a fishs spines
3. Evolutions twist
4. New Understanding Evolution Web site provides one-stop-shop for nations science teachers
5. Evolution caught in the act
6. Evolutionary Genomics meeting in Tucson
7. Evolution upset: Oxygen-making microbes came last, not first
8. Evolution: Driving Change
9. Evolution of language: FOXP2 and human uniqueness in religious perspective
10. Rutgers to host 14th annual Human Behavior and Evolution Society meeting
11. Evolutionary speed limit governs how quickly life bounces back after extinction

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/8/2019)... ... May 07, 2019 , ... ... Council, an invitation-only community for world-class CIOs, CTOs, and technology executives. ... chain engineering firm that guarantees confidence in a company’s cold chain. Subject-matter ...
(Date:5/8/2019)... CITY (PRWEB) , ... May 08, 2019 , ... ... small sensor, with a diameter of 200 microns and a lead-in fiber of ... establishing the new industry standard and positioning itself as the world leader in ...
(Date:5/2/2019)... ... April 30, 2019 , ... Global molecular diagnostics ... that Holotype HLA and other Omixon products will be featured in 12 poster ... in Lisbon, Portugal. Among the major scientific events, Omixon’s Lunch Symposium ...
Breaking Biology News(10 mins):
(Date:5/8/2019)... ... May 07, 2019 , ... Standing at 16.2 hands, Atlas is on the large side ... drill team and barrel racing, among other activities. When loping around a corner in ... from being a busy horse to only being able to walk. Fortunately Atlas’ owner, ...
(Date:5/4/2019)... , ... May 03, 2019 , ... ... the President of the Dakila Pesquisas Association, the scientist and ufologist Urandir Fernandes ... in Brasília (DF). Urandir detailed the results of some research carried out by ...
(Date:5/2/2019)... ... April 30, 2019 , ... ... Organization for Standardization ISO 9001:2015 standard, REPROCELL USA Inc. has demonstrated its ... In addition, REPROCELL USA Inc. aims to enhance customer satisfaction through the ...
(Date:5/2/2019)... ... May 02, 2019 , ... Stay on top of ... device and food industries. Access to all webinars is free, so be sure to ... your field! , Visit http://www.xtalks.com to see our upcoming webinars: , CLINICAL ...
Breaking Biology Technology:
Cached News: