HOME >> BIOLOGY >> NEWS
Excess Thiamine May Help Tumor Growth, Research Shows

COLUMBUS, Ohio -- Vitamin B1, which is usually given in excess to many cancer patients, should be carefully regulated in people undergoing cancer therapy, new research shows.

The findings reveal a long overlooked link between vitamin B1 -- also known as thiamine -- and tumor-cell growth. The results suggest that too much thiamine may actually help tumors grow. They also suggest that rational use of dietary thiamine may help slow tumor growth.

Thiamine supplementation is commonly recommended to cancer patients to counteract vitamin B1 deficiencies that can occur with leukemias, gastrointestinal tumors, and other faster-growing malignancies. Thiamine deficiency is also a side effect of some kinds of chemotherapy.

Severe thiamine deficiencies can lead to nervous system and memory impairment, and the build-up of lactic acid in the blood.

Thiamine supplementation is therefore often essential for cancer patients. However, total thiamine levels in a patient’s diet can be 250 to 20,000 percent of the normal daily recommended allowance. The government recommends that men consume 1.4 mg and women 1.0 mg of thiamine per day, amounts that are easily obtained from a typical American diet. Medical texts recommend 3 mg of thiamine daily for cancer patients, a dose that needs to be re-evaluated in light of this new research.

Physicians normally don’t worry about excess thiamine because the vitamin is water-soluble, and the body eliminates what it doesn’t need. This study indicates, however, that excess thiamine may contribute to tumor-cell proliferation and to the development of chemotherapy resistance by tumors.

“Cancer patients should be evaluated for their thiamine status, and supplementation should be administered only to meet the patient’s needs,” said Laszlo Boros, a research scientist in the Department of Surgery at Ohio State University.

The study by Boros and an interdisciplina
'"/>

Contact: Laszlo Boros
Boros.1@osu.edu
614-292-0828
Ohio State University
17-Jun-1998


Page: 1 2 3

Related biology news :

1. Excess thyroid hormone harmful to fetus
2. Excess levels of nitrogen, phosphorus linked to deformed frogs
3. Excessive growth of bacteria may also be major cause of stomach ulcers
4. Excessive fishing prompted coastal ecosystems to collapse, but wise management now will help
5. Excess iron stores more common than anemia in study of U.S. elderly
6. Choice of sex in animal breeding? Excess of male progeny from males carrying mouse responder transgene on Y chromosome
7. Intake Of Acetaminophen Increases Risk Of Excessive Anticoagulation In Patients Taking Warfarin
8. Tumor cell-specific therapy shows preclinical promise
9. Tumor cells made more sensitive to radiation by blocking a key cellular molecule
10. Discovery Of 13 Genes Expressed In Brain Tumors May Lead To More Effective Diagnosis Or Prevention
11. Dietary Lutein Inhibits Mammary Tumor Growth And Normalizes Immune Balance In Tumor-Bearing Mice

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Excess Thiamine May Help Tumor Growth Research Shows

(Date:5/21/2013)... charted the path of insulin action in cells in ... blueprint for understanding what goes wrong in diabetes. ... Professor David James from Sydney,s Garvan Institute of Medical ... of the prestigious journal Cell Metabolism . , ... very important role in the body because it helps ...
(Date:5/20/2013)... N.Y. Little is known about the effect of ... study from Cornell University finds that increasing the amount ... reduces the probability of obesity. , The study represents ... of PE on youth obesity, and is forthcoming in ... early, online version of the study can be viewed ...
(Date:5/20/2013)... A new study conducted at the University of Bristol ... Evolutionary Biology sheds light on how the brain ... Lautenschlager from Bristol,s School of Earth Sciences, together with ... picked the brains of 150 million year old dinosaurs. ... Jurassic dinosaur Dysalotosaurus lettowvorbecki : a very young ...
Breaking Biology News(10 mins):Insight into the dazzling impact of insulin in cells 2Insight into the dazzling impact of insulin in cells 3Gym class reduces probability of obesity, study finds for first time 2Fossil brain teaser 2
(Date:5/21/2013)... , May 21, 2013  On May ... FCN ), the global business advisory firm dedicated ... value (the "Company"), announced that it has combined ... were formerly included within the Corporate Finance/Restructuring segment ... segment to form a single integrated practice whose ...
(Date:5/21/2013)... Through science fairs, workshops, kits for building optical ... organizations will continue their work to increase awareness about ... daily life with the aid of SPIE Education ... countries, are the first of two groups of recipients ... international society for optics and photonics , in 2013. ...
(Date:5/21/2013)... The congress of the ERA-EDTA ... the biggest congress in Europe ... are in Istanbul to share ... pioneering studies have been presented: / (1) ... VIA HEMODIALYSATE REDUCES ESA USE" By SFP-iron ...
(Date:5/21/2013)... Austin, TX (PRWEB) May 21, 2013 ... and outdoor security solutions, today announced that Genzyme, a ... more units of Door Detective® CL for a multi-use ... already installed in four other Genzyme buildings, this latest ... had with the tailgate detection device improving ...
Breaking Biology Technology:FTI Consulting Releases Realigned Segment Information Reflecting Newly Combined Health Solutions Practice 2Learning About Light: Education Outreach Projects Funded in 10 Countries Through First Round of SPIE Grants 2Learning About Light: Education Outreach Projects Funded in 10 Countries Through First Round of SPIE Grants 3ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 2ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 3Door Security at Genzyme, a Sanofi Company, Enhanced with Door Detective from Smarter Security 2Door Security at Genzyme, a Sanofi Company, Enhanced with Door Detective from Smarter Security 3
Cached News: