HOME >> BIOLOGY >> NEWS
Excess thyroid hormone harmful to fetus

Researchers from the University of Chicago have showed, for the first time, that an excess of thyroid hormone during pregnancy has a direct toxic effect on the fetus, tripling the risk of miscarriage and reducing the average birth weight of infants who survive.

The problems caused by a lack of sufficient thyroid hormone during pregnancy are well known and approximately two percent of all pregnant women now take supplements to prevent a shortage. A recent article in the New England Journal of Medicine proposed that all women being treated prior to conception for low thyroid hormone -- a common occurrence -- "increase the dose by 29 percent" as soon as they learn they are pregnant.

The University of Chicago study, however, published in the 11 August 2004 issue of JAMA, shows that increasing the dose without careful testing is hazardous. Overcompensating for a mother's shortage of thyroid hormone, the authors note, can be equally harmful.

"Although the risks of insufficient thyroid hormone during pregnancy are established," said study author Samuel Refetoff, M.D., professor of medicine and pediatrics and the committees on genetics and molecular medicine at the University of Chicago, "we have not, until now, been able to determine the consequences of an excess. We now see that having too much is just as bad as having too little. This tells us that hormonal replacement must be assessed and fine-tuned so as not to exceed the normal requirements."

Physicians have not been able to study the effect on the fetus of excess thyroid hormone, which regulates metabolism, because it was impossible to separate the effects on the fetus from the effects on the mother.

This innovative study, however, provides a perfect example of how "errors of nature can help us understand normal hormone action," said Refetoff.

Nearly 40 years ago, he found such an error. In 1967, Refetoff described a clinical syndrome involving resistance to thyroi
'"/>

Contact: John Easton
jeaston@uchospitals.edu
773-702-6241
University of Chicago Medical Center
10-Aug-2004


Page: 1 2 3

Related biology news :

1. Excess levels of nitrogen, phosphorus linked to deformed frogs
2. Excessive growth of bacteria may also be major cause of stomach ulcers
3. Excessive fishing prompted coastal ecosystems to collapse, but wise management now will help
4. Excess iron stores more common than anemia in study of U.S. elderly
5. Choice of sex in animal breeding? Excess of male progeny from males carrying mouse responder transgene on Y chromosome
6. Excess Thiamine May Help Tumor Growth, Research Shows
7. Intake Of Acetaminophen Increases Risk Of Excessive Anticoagulation In Patients Taking Warfarin
8. Genetic differences might help distinguish thyroid cancers
9. Chernobyl study: Risk of thyroid cancer rises with radiation dose
10. SAGE-acious prediction of thyroid carcinoma
11. Common thyroid cancer gene mutation found

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/17/2019)... ... July 18, 2019 , ... ... Meredith James, HT, PMP, to its executive team as Vice President of Operations. ... drug development. In her new role, Ms. James is responsible for ensuring on-time ...
(Date:7/17/2019)... ... 15, 2019 , ... RCH Solutions (RCH), a ... companies, announces the availability of new specialty advisory practice, a Public Cloud Managed ... emerging bio-pharma companies interested in achieving specific outcomes related to public Cloud adoption. ...
(Date:7/17/2019)... ... ... Imagine using a simple, portable test to detect cancer before malignant tissues ... South Dakota School of Mines & Technology researcher Congzhou Wang, Ph.D., these ideas are ... to monitor and prevent disease,” says Wang. , Wang, an assistant professor in ...
Breaking Biology News(10 mins):
(Date:7/26/2019)... ... July 25, 2019 , ... LeadingBiotech , an exclusive ... announces its Boston BD conference to be held on September 10, ... Boston , the event provides an opportunity for attendees to leverage insight from ...
(Date:7/17/2019)... , ... July 16, 2019 ... ... long-term strategic agreement for the development and manufacturing of Zolgensma® (onasemnogene abeparvovec-xioi), ... this collaboration, AveXis, a Novartis company, will have dedicated manufacturing space at ...
(Date:7/2/2019)... ... July 02, 2019 , ... Leading Regenerative Veterinary Medicine company, ... Where Beasts Meet Biotech. The film focuses on regenerative veterinary medicine as a ... Pharm was recently included in the Brentwood and Pacific Palisades International Film ...
(Date:6/11/2019)... ... June 10, 2019 , ... Thought Technology Ltd is ... of Biofeedback Tech Ltd as its authorised distributor for the UK ... many therapeutic treatments and clinical assessment protocols to treat stress related disorders as ...
Breaking Biology Technology:
Cached News: