Exercise and healthy weight delay cancer even among women with highest genetic risk

Women who carry inherited mutations in the genes BRCA1 or BRCA2 have a lifetime risk of breast cancer of more than 80 percent, as well as a high risk of ovarian cancer, according to the most comprehensive study to date of these women and their families.

The study, published by The New York Breast Cancer Study Group in the Oct. 24 edition of Science, also found that many women with these inherited mutations come from families with few if any reports of breast or ovarian cancer.

The good news from the study is that even among women at very high risk, exercise and healthy weight as an adolescent delayed the onset of breast cancer.

"It was a surprise, but a source of hope, to learn that factors over which we have some control made a difference in the age at which these highest-risk women developed breast cancer," said the lead author, Mary-Claire King, Ph.D. King is American Cancer Society Professor of Genome Sciences and Medicine at the University of Washington in Seattle and a pioneer in the study of the link between inherited genetic alterations and disease. "Women with inherited mutations were at extremely high risk, but exercise and appropriate weight during their adolescent years clearly delayed the onset of breast cancer."

"The possibility that lifestyle changes such as increased exercise and weight control could modify the impact of genetic risk has very intriguing implications, not only for BRCA-related cancers but for other breast cancers as well," said Dr. Larry Norton, head of the Division of Solid Tumor Oncology and Norna S. Serafim Chair in Clinical Oncology at Memorial Sloan-Kettering Cancer Center.

The research was conducted with financial support from The Breast Cancer Research Foundation of New York.

Previous studies had suggested widely varying estimates of breast cancer risk ranging from 25 percent to 80 percent among women with BRCA1 and BRCA2 mutations. In order to resolve these discrepancies and accurately calc

Contact: Walter Neary
University of Washington

Page: 1 2 3 4 5 6 7

Related biology news :

1. Exercise reduces blood estrogens, risk for breast cancer in post menopausal women
2. Exercise measures identify heart disease in seemingly healthy women
3. Exercise and imaging tests predict heart events in high-risk families
4. Exercise and recreation for people with mobility impairments
5. Exercise helps diabetics control heart-related problems
6. Exercise effects dependent on time of day
7. Exercise benefits patients being treated for early stage breast cancer
8. Exercise and weight loss effective in reducing high blood pressure for overweight individuals
9. Exercise improves learning and memory
10. Duke study: Exercise may be just as effective as medication for treating major depression
11. University Of Texas Southwestern Researchers Find Genetic Switch That Explains Effect Of Exercise On Muscles

Post Your Comments:

(Date:8/7/2020)... (PRWEB) , ... August 06, 2020 , ... ... sciences industry, is pleased to announce that Eric Chen and Jessica Wong have ... of Product Management & Strategy, respectively. , Eric Chen heads development efforts for ...
(Date:7/31/2020)... ... July 30, 2020 , ... BioFactura, Inc. today ... by the Joint Science & Technology Office—Chemical and Biological Defense (JSTO-CBD) of the ... and scale-up a highly efficient mammalian cell culture-based bioprocess suitable to meet surge ...
(Date:7/18/2020)... ... July 17, 2020 , ... Commercial launch readiness is a critical stage ... a COVID cure or vaccine, the global economic downturn will only increase price pressures ... going away and capturing full value from every product launch is critical. However, history ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... 2020 , ... Sentien Biotechnologies, Inc., a clinical-stage biotechnology company ... Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. Dr. Nissenson will join ... Dr. Nissenson serves as an Emeritus Professor of Medicine at the David ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT World has announced the ... Squibb, the University of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia ... program, highlighting outstanding examples of how technology innovations and strategic initiatives can be ...
(Date:7/1/2020)... ... June 29, 2020 , ... ... procured purchasing contracts to its membership, recently named BioFit Engineered Products ... the opportunity to purchase ergonomic seating, cafeteria tables, book trucks and carts at ...
(Date:6/28/2020)... ... June 25, 2020 , ... The Indoor Lab, a leading ... Space™ for businesses of all types to ensure cleanliness, distancing and occupancy with its ... A Safe Space™ enabled business will provide a health performance index system that scores ...
Breaking Biology Technology:
Cached News: