HOME >> BIOLOGY >> NEWS
Expanding the genetic code--TSRI scientists synthesize 21-amino-acid bacterium

Scientists at The Scripps Research Institute (TSRI) report in an upcoming article in the Journal of the American Chemical Society their synthesis of a form of the bacterium Escherichia coli with a genetic code that uses 21 basic amino acid building blocks to synthesize proteins--instead of the 20 found in nature.

This is the first time that anyone has created a completely autonomous organism that uses 21 amino acids and has the metabolic machinery to build those amino acids.

"We now have the opportunity to ask whether a 21-amino acid form of life has an evolutionary advantage over life with 20 amino acids," says the report's lead author Peter Schultz, Ph.D., TSRI professor of chemistry and Scripps Family Chair of TSRI's Skaggs Institute of Chemical Biology.

"We have effectively removed a billion-year constraint on our ability to manipulate the structure and function of proteins," he says.

In addition to demonstrating that life is possible with additional amino acids, the work is of great relevance to science and medicine because it enables scientists to chemically manipulate the proteins that an organism produces within the organism itself. This gives scientists a powerful tool for research, from determining molecular structures to creating molecular medicines.

Why Expand the Genetic Code?

Life as we know it is composed, at the molecular level, of the same basic building blocks for instance, all life forms on Earth use the same four nucleotides to make DNA. And almost without exception, all known forms of life use the same common 20 amino acids--and only those 20--to make proteins.

"The question is," asks Schultz, "why did life stop with 20 and why these 20?"

While the answer to that question may be elusive, the 20-amino acid barrier is far from absolute. In some rare instances, in fact, certain organisms have evolved the ability to use the unusual amino acids selenocysteine and pyrrolysine--sli
'"/>

Contact: Jason Bardi
jasonb@scripps.edu
858-784-9254
Scripps Research Institute
14-Jan-2003


Page: 1 2 3 4

Related biology news :

1. Expanding the genetic code: the worlds first truly unnatural organism
2. Expanding lifes alphabet
3. Researchers determine genetic cause of Timothy syndrome
4. Rare childhood genetic syndrome identified
5. New research shows plants can shuffle and paste gene pieces to generate genetic diversity
6. Scientists decipher genetic code of biothreat pathogen
7. Chemical genetics identifies SARS inhibitors
8. 22nd amino acid synthesized and added to genetic code of e. coli bacteria
9. The impact of genetic variations on the treatment of early rheumatoid arthritis
10. Adaptive changes in the genome may provide insight into the genetics of complex disease
11. New genetic hypothesis for the cause of autism

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2016)... physicians supporting Medicaid patients in Central Florida ... telehealth thanks to a new partnership with higi.   ... can routinely track key health measurements, such as blood ... they opt in, share them with IMPOWER clinicians through ... location at no cost. By leveraging this data, IMPOWER ...
(Date:3/22/2016)... March 22, 2016 ... Sensors Market for Consumer Industry by Type (Image, ... Application (Communication & IT, Entertainment, Home Appliances, ... Forecast to 2022", published by MarketsandMarkets, the ... to reach USD 26.76 Billion by 2022, ...
(Date:3/15/2016)... --> --> ... Research "Digital Door Lock Systems Market - Global Industry Analysis, ... global digital door lock systems market in terms of revenue ... forecast to grow at a CAGR of 31.8% during the ... enterprises (MSMEs) across the world and high industrial activity driving ...
Breaking Biology News(10 mins):
(Date:5/24/2016)...   MedyMatch Technology Ltd ., the data analytics healthcare ... support tools in the emergency room, announced today that it ... Technology Industries (IATI) BioMed Conference. The Conference ... National Life Sciences and Technology Week, and is being held ... Tel Aviv, Israel . Gene Saragnese ...
(Date:5/24/2016)... , ... May 24, 2016 , ... ... newly re-branded identity. The new Media Cybernetics corporate branding reflects a results-driven revitalization ... imaging and image analysis. The re-branding components include a crisp, refreshed logo and ...
(Date:5/23/2016)... ... May 23, 2016 , ... ... Precision Farming in 2017 and Beyond. The paper outlines the key trends that ... ag industry. , “We’ve witnessed a lot of highs and lows as the ...
(Date:5/23/2016)... OXFORD, England , May 23, 2016 ... Wednesday, May 25 th at 10:15 a.m. ET before ... about the role genetically engineered mosquitos can play in controlling ... known carrier of the Zika virus.      (Logo: ... genetically engineered male mosquito with a self-limiting gene. Trials in ...
Breaking Biology Technology:
Cached News: