HOME >> BIOLOGY >> NEWS
Experimental Staph Vaccine Broadly Protective In Animal Studies

Researchers supported by the National Institute of Allergy and Infectious Diseases (NIAID) have developed a vaccine that protects mice against multiple strains of Staphylococcus aureus (S. aureus), an increasingly stubborn microbe and the most common cause of hospital-acquired infections. The new vaccine is the first to be made from a bacterial molecule produced primarily during infection, rather than in laboratory culture. A report of the study by scientists at Brigham and Women's Hospital and Harvard Medical School in Boston appears in the May 28, 1999, issue of Science.

"This is an intriguing finding and a hopeful step against a very worrisome pathogen," says NIAID Director Anthony S. Fauci, M.D. "Within the last two years, S. aureus has become increasingly resistant to antibiotics. Most troubling is the emergence of strains that are partially resistant to vancomycin, our last line of defense against S. aureus. New treatments and, ideally, an effective vaccine, are urgently needed."

Each year an estimated 500,000 patients in American hospitals contract staph infections. S. aureus, the chief culprit, also is a common source of community acquired infections, and causes illnesses that range from minor skin infections and abscesses to life-threatening diseases such as severe pneumonia, meningitis, bone and joint infections, and infections of the heart and bloodstream.

Molecules isolated from bacteria grown in the laboratory have been one source of new vaccine candidates. However, since bacterial growth under laboratory conditions may not mimic an actual infection, scientists recently have begun searching for bacterial products that are activated specifically during infection.

"Presumably, these products are critical for infection and disease progression, and would therefore be logical targets for new therapeutics or vaccines," explains Gerald B. Pier, Ph.D., who led the research team that developed the new S. aureus vaccine.

The resear
'"/>

Contact: John Bowersox
jbowersox@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
28-May-1999


Page: 1 2 3

Related biology news :

1. Experimental drug shown to block mutant protein causing blood disease
2. Experimental smallpox DNA vaccine protects primates from lethal monkeypox
3. Experimental smallpox vaccine protects against monkeypox in nonhuman primates
4. Experimental Biology 2004 - Translating the Genome
5. Experimental Biology 2004 meets in Washington, D.C. April 17-21
6. Experimental hantavirus vaccine elicits strong antibody response in primates
7. Experimental cancer drugs may halt events that lead to cardiac hypertrophy and heart failure
8. Experimental Biology 2003 meets in San Diego April 11-15
9. Experimental Biology 2003 meets in San Diego April 11-15
10. Experimental gene switch increases lifespan with no ill effects
11. Experimental therapy stops allergic reactions in mice

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2019)... ... , ... The newest edition of Crystallography Times from Rigaku ... , Crystallography Times is a monthly electronic newsletter published by Rigaku Oxford Diffraction ( ... by presenting the latest news and crystallographic research. , “Crystallography in the News” ...
(Date:5/23/2019)... (PRWEB) , ... May 23, 2019 , ... ... technologies and development solutions for drugs, biologics and consumer health products, is to ... of biologic drugs at the BIO International Convention, which takes place at the ...
(Date:5/22/2019)... ... May 22, 2019 , ... Leak ... testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ ... Industrial Production Processes (IPP) Ltd has been signed. The agreement will grant ...
Breaking Biology News(10 mins):
(Date:5/4/2019)... ... May 03, 2019 , ... More than three ... Pesquisas Association, the scientist and ufologist Urandir Fernandes de Oliveira, last Thursday (25), ... the results of some research carried out by the association, in partnership with ...
(Date:5/2/2019)... TORONTO (PRWEB) , ... May 02, 2019 , ... Stay ... pharma, biotech, medical device and food industries. Access to all webinars is free, so ... stay relevant in your field! , Visit http://www.xtalks.com to see our upcoming ...
(Date:4/25/2019)... , ... April 24, 2019 , ... ... Agents for sales and service organizations, today announced global availability of Inference ... providers and enterprises of all sizes to harness the power of Google’s ...
(Date:4/15/2019)... ... April 15, 2019 , ... Sirrus, Inc., a developer of ... plant expansion to increase production of methylene malonate monomers and oligomers. , The ... Sirrus’ full-scale production facility, which is scheduled to break ground in 2019. “The ...
Breaking Biology Technology:
Cached News: