HOME >> BIOLOGY >> NEWS
Experimental 'gene switch' increases lifespan with no ill effects

By experimentally switching genes off or on at specific stages in an animal's lifecycle, UCSF scientists have discovered that vigor and lifespan can be significantly extended with no side effects. Many researchers believe that increasing lifespan will dampen reproduction. But the new study of the tiny roundworm commonly known as C. elegans shows that silencing a key gene only in adulthood increases longevity with no effect on reproduction.

The focus of the research is a set of genes that control a hormonal pathway. Since the same or a similar pathway is found in many organisms including humans, the results offer the tantalizing prospect of safely and effectively extending the human lifespan as well.

The research is published in the October 25 issue of the journal SCIENCE.

Many experiments in different organisms have supported the evolutionary principle that everything comes at a price that tweaking hormone levels to boost lifespan will inevitably cause abnormal reproduction. But in the new study, UCSF scientists report for the first time that the hormonal pathways controlling reproduction and longevity act independently and can be decoupled.

Typically, to study a gene's effect, researchers knock out the gene's activity permanently. But the scientists were able to use a new technique to turn genes off at different times and thereby learn that the genes had different effects at different stages in the life of the worm. They were also able to turn the "off" genes "on" again to further probe the timing of their influence.

The UCSF scientists studied a now well-known gene called daf-2. In previously research they showed that partially disabling the gene doubles the worm's lifespan. The gene encodes a receptor for insulin as well as for a hormone called insulin-like growth factor. The same or related hormone pathways have since been shown to affect lifespan in fruit flies and mice, and therefore are likely to control lifespan in h
'"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
24-Oct-2002


Page: 1 2 3 4

Related biology news :

1. Experimental drug shown to block mutant protein causing blood disease
2. Experimental smallpox DNA vaccine protects primates from lethal monkeypox
3. Experimental smallpox vaccine protects against monkeypox in nonhuman primates
4. Experimental Biology 2004 - Translating the Genome
5. Experimental Biology 2004 meets in Washington, D.C. April 17-21
6. Experimental hantavirus vaccine elicits strong antibody response in primates
7. Experimental cancer drugs may halt events that lead to cardiac hypertrophy and heart failure
8. Experimental Biology 2003 meets in San Diego April 11-15
9. Experimental Biology 2003 meets in San Diego April 11-15
10. Experimental therapy stops allergic reactions in mice
11. APS awards 44 minority travel fellowships to the Experimental Biology 2002 meeting

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... -- The Allen Institute for Cell Science today announces the ... and dynamic digital window into the human cell. The ... of deep learning to create predictive models of cell ... growing suite of powerful tools. The Allen Cell Explorer ... available resources created and shared by the Allen Institute ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... anticipated to expand at a CAGR of 25.76% during ... diseases is the primary factor for the growth of ... report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global ... product, technology, application, and geography. The stem cell market ...
(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... FirstHand program has won a US2020 STEM Mentoring Award. Representatives of the FirstHand ... Excellence in Volunteer Experience from US2020. , US2020’s mission is to change the ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program Committee ... honoring scientists who have made outstanding contributions to analytical chemistry and applied ... the world’s leading conference and exposition for laboratory science, which will be held ...
(Date:10/9/2017)... (PRWEB) , ... October 09, ... ... published on October 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s ... the gold standard, video EEG, in detecting generalized tonic-clonic seizures (GTCS) using ...
(Date:10/6/2017)... ... 2017 , ... On Tuesday, October 24th, ABC² (Accelerate Brain ... adaptive clinical trial for glioblastoma (GBM). The featured speaker will be Dr. Brian ... to the public, but registration is required. , WHAT: ABC² Brain Cancer ...
Breaking Biology Technology:
Cached News: