HOME >> BIOLOGY >> NEWS
Experimental hantavirus vaccine elicits strong antibody response in primates

For the first time, scientists have demonstrated that an experimental vaccine to hantavirus pulmonary syndrome (HPS), a highly lethal disease, elicits a strong neutralizing antibody response in laboratory animals--a response that is key to preventing the virus from causing infection.

In addition, the antibodies, produced in nonhuman primates that received the vaccine, protected hamsters from disease even when administered 5 days after exposure.

These findings provide proof of concept in nonhuman primates for a vaccine against HPS, as well as for post exposure prophylactic treatment of HPS and a related disease known as hemorrhagic fever with renal syndrome (HFRS).

In an article published in last month's Journal of Virology, investigators at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) describe using a naked DNA approach to develop a hantavirus vaccine. The technique involves vaccination with plasmid DNA that encodes a specific hantavirus gene. When the plasmid DNA is introduced into the cells of a vaccine recipient, using a harmless device called a "gene gun," the cloned gene is expressed and presented to the immune system.

According to senior author Jay W. Hooper, Ph.D., the USAMRIID team constructed an expression plasmid containing the full-length M genome segment of Andes virus, a South American hantavirus. Vaccination with the plasmid elicited a potent neutralizing antibody response in rhesus macaques that were vaccinated a total of four times at three-week intervals.

To look at the duration of that response, the team collected serum samples for about six months. The monkeys who received the Andes vaccine displayed robust antibody levels as long as 25 weeks after the last vaccination.

Hantaviruses are carried by rodents and have caused epidemics in Europe, Asia, and the Americas. Some cause HPS, while others are responsible for the more common HFRS. The viruses are patho
'"/>

Contact: Caree Vander Linden
Caree.Vander-Linden@amedd.army.mil
301-619-2285
US Army Medical Research Institute of Infectious Diseases
23-Oct-2003


Page: 1 2 3

Related biology news :

1. Experimental drug shown to block mutant protein causing blood disease
2. Experimental smallpox DNA vaccine protects primates from lethal monkeypox
3. Experimental smallpox vaccine protects against monkeypox in nonhuman primates
4. Experimental Biology 2004 - Translating the Genome
5. Experimental Biology 2004 meets in Washington, D.C. April 17-21
6. Experimental cancer drugs may halt events that lead to cardiac hypertrophy and heart failure
7. Experimental Biology 2003 meets in San Diego April 11-15
8. Experimental Biology 2003 meets in San Diego April 11-15
9. Experimental gene switch increases lifespan with no ill effects
10. Experimental therapy stops allergic reactions in mice
11. APS awards 44 minority travel fellowships to the Experimental Biology 2002 meeting

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... ... August 19, 2020 , ... ... expo uniting life science, data science, informatics and IT leaders goes VIRTUAL and ... period of uncertainty and change, Bio-IT takes the leadership role of keeping our ...
(Date:8/12/2020)... ... August 11, 2020 , ... ... in Princeton, NJ, have entered into license agreements with Housey Pharma’s HMI subsidiary ... Both Roche and J&J have annual Research and Development spending in excess of ...
(Date:8/7/2020)... ... August 06, 2020 , ... Alucio™, a fast-growing ... that Eric Chen and Jessica Wong have joined the company’s leadership team as ... , Eric Chen heads development efforts for Alucio’s flagship product, Beacon, an innovative ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... Ariz. (PRWEB) , ... July 29, 2020 , ... R3 ... joint injections for only $3950. With 50 million stem cells total, patients may choose ... stem cell therapy works for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, ...
(Date:7/31/2020)... , ... July 29, 2020 , ... ... solid-state radar transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, ... that can drive one or two switches in a push-pull configuration; yielding fast ...
(Date:7/31/2020)... ... July 29, 2020 , ... Editas ... global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, ... entered into a strategic partnership whereby Catalent will provide support for the development, ...
(Date:7/31/2020)... MIAMI (PRWEB) , ... July 29, 2020 , ... ... nearly 200 of the top radiation centers in 16 countries, has reached its ... years, SDX® is now in routine use at top universities including University of ...
Breaking Biology Technology:
Cached News: