HOME >> BIOLOGY >> NEWS
Experimental smallpox DNA vaccine protects primates from lethal monkeypox

In the first successful study of its kind, scientists have shown that a DNA-based vaccine for smallpox can protect nonhuman primates from monkeypox, a disease that resembles smallpox in humans. The study, performed at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) and published in the May issue of the Journal of Virology, suggests a promising alternative approach to conventional smallpox vaccination.

Smallpox, a devastating disease caused by the variola virus, was eradicated in 1979 through the efforts of the World Health Organization (WHO). Currently, infectious variola (one of a class of viruses called orthopoxviruses) is known to exist only in two WHO-sanctioned repositories, one in Russia and the other in the United States. However, there is concern that undisclosed reference stocks of the virus may exist, and its potential as a biological weapon has led to the production and stockpiling of smallpox vaccine and the immunization of some healthcare workers.

The USAMRIID team, led by Jay W. Hooper, Ph.D., based its DNA vaccine on four genes from vaccinia virus--the same virus used in Dryvax, the licensed smallpox vaccine. Because Dryvax contains live virus, it carries a high risk of complications for people with suppressed immunity and other conditions. A DNA vaccine would not have the adverse side effects commonly associated with a live virus vaccine.

"This work represents important progress toward a smallpox vaccine that is as effective as the current product, but safer," said Colonel Erik A. Henchal, commander of USAMRIID. "It is yet another example of how USAMRIID research to protect military service members can contribute to the overall public health."

As smallpox no longer occurs naturally, experimental vaccines cannot be tested for their ability to prevent the disease in humans. Thus, licensing of future vaccine candidates will include studies of immune response and protection in nonhuman pri
'"/>

Contact: Caree Vander Linden
Caree.Vander-Linden@amedd.army.mil
301-619-2285
US Army Medical Research Institute of Infectious Diseases
27-Apr-2004


Page: 1 2 3 4

Related biology news :

1. Experimental drug shown to block mutant protein causing blood disease
2. Experimental smallpox vaccine protects against monkeypox in nonhuman primates
3. Experimental Biology 2004 - Translating the Genome
4. Experimental Biology 2004 meets in Washington, D.C. April 17-21
5. Experimental hantavirus vaccine elicits strong antibody response in primates
6. Experimental cancer drugs may halt events that lead to cardiac hypertrophy and heart failure
7. Experimental Biology 2003 meets in San Diego April 11-15
8. Experimental Biology 2003 meets in San Diego April 11-15
9. Experimental gene switch increases lifespan with no ill effects
10. Experimental therapy stops allergic reactions in mice
11. APS awards 44 minority travel fellowships to the Experimental Biology 2002 meeting

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/16/2019)... ... June 14, 2019 , ... ... customer, will deliver a joint presentation with Versiti’s CIO at the Healthcare ... the Rosen Shingle Creek Resort. , Versiti Vice President and Chief Information Officer, ...
(Date:6/13/2019)... ... June 13, 2019 , ... KICVentures announced today its ... Spine, Orthopedic and Pain Management-Driven ASC Conference in Chicago on Thursday, June 13th at ... Wacker Dr. Chicago, IL in the 3rd floor Ticino Hospitality room in space #74T. ...
(Date:6/11/2019)... Zealand (PRWEB) , ... June 12, 2019 , ... ... range of antibody discovery services, Abveris plans to leverage the Geneious Biologics platform ... Dr. Colby Souders, Chief Technology Officer at Abveris, says: “The Geneious team has ...
Breaking Biology News(10 mins):
(Date:5/14/2019)... ... May 14, 2019 , ... Gateway Genomics , a leading ... space from 2,500 to 5,000 square feet. , “This past year has seen ... says Gateway Genomics CEO, Chris Jacob. “The SneakPeek At-Home test, which is mailed directly ...
(Date:5/4/2019)... ... May 03, 2019 , ... More than three ... Pesquisas Association, the scientist and ufologist Urandir Fernandes de Oliveira, last Thursday (25), ... the results of some research carried out by the association, in partnership with ...
(Date:5/2/2019)... S.D. (PRWEB) , ... April 30, 2019 , ... The ... from industrial scale macro breweries to local craft breweries, and even home brewing clubs ... very complex chemical and biological processes, that when mastered can produce a superb product. ...
(Date:5/2/2019)... BOSTON (PRWEB) , ... May 02, 2019 , ... ... hair transplantation clinic in the greater Boston area. Gone are the days of ... The ARTAS® iX Robotic Hair Restoration System is the only robotic intelligent solution ...
Breaking Biology Technology:
Cached News: