HOME >> BIOLOGY >> NEWS
Experimental smallpox DNA vaccine protects primates from lethal monkeypox

In the first successful study of its kind, scientists have shown that a DNA-based vaccine for smallpox can protect nonhuman primates from monkeypox, a disease that resembles smallpox in humans. The study, performed at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) and published in the May issue of the Journal of Virology, suggests a promising alternative approach to conventional smallpox vaccination.

Smallpox, a devastating disease caused by the variola virus, was eradicated in 1979 through the efforts of the World Health Organization (WHO). Currently, infectious variola (one of a class of viruses called orthopoxviruses) is known to exist only in two WHO-sanctioned repositories, one in Russia and the other in the United States. However, there is concern that undisclosed reference stocks of the virus may exist, and its potential as a biological weapon has led to the production and stockpiling of smallpox vaccine and the immunization of some healthcare workers.

The USAMRIID team, led by Jay W. Hooper, Ph.D., based its DNA vaccine on four genes from vaccinia virus--the same virus used in Dryvax, the licensed smallpox vaccine. Because Dryvax contains live virus, it carries a high risk of complications for people with suppressed immunity and other conditions. A DNA vaccine would not have the adverse side effects commonly associated with a live virus vaccine.

"This work represents important progress toward a smallpox vaccine that is as effective as the current product, but safer," said Colonel Erik A. Henchal, commander of USAMRIID. "It is yet another example of how USAMRIID research to protect military service members can contribute to the overall public health."

As smallpox no longer occurs naturally, experimental vaccines cannot be tested for their ability to prevent the disease in humans. Thus, licensing of future vaccine candidates will include studies of immune response and protection in nonhuman pri
'"/>

Contact: Caree Vander Linden
Caree.Vander-Linden@amedd.army.mil
301-619-2285
US Army Medical Research Institute of Infectious Diseases
27-Apr-2004


Page: 1 2 3 4

Related biology news :

1. Experimental drug shown to block mutant protein causing blood disease
2. Experimental smallpox vaccine protects against monkeypox in nonhuman primates
3. Experimental Biology 2004 - Translating the Genome
4. Experimental Biology 2004 meets in Washington, D.C. April 17-21
5. Experimental hantavirus vaccine elicits strong antibody response in primates
6. Experimental cancer drugs may halt events that lead to cardiac hypertrophy and heart failure
7. Experimental Biology 2003 meets in San Diego April 11-15
8. Experimental Biology 2003 meets in San Diego April 11-15
9. Experimental gene switch increases lifespan with no ill effects
10. Experimental therapy stops allergic reactions in mice
11. APS awards 44 minority travel fellowships to the Experimental Biology 2002 meeting

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: