HOME >> BIOLOGY >> NEWS
Experimental smallpox vaccine protects against monkeypox in nonhuman primates

Scientists evaluating MVA, a potential safer replacement for the licensed Dryvax smallpox vaccine, have shown that MVA elicits an immune response comparable to that of Dryvax in a monkeypox model of human disease. In addition, MVA protected nonhuman primates exposed to lethal doses of the monkeypox virus.

The study, published in the March 11th issue of the journal NATURE, is a collaborative effort involving a team of scientists from the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), the National Institute of Allergy and Infectious Diseases (NIAID), the Henry M. Jackson Foundation, and the University of Pennsylvania.

Their findings represent an important step in the search for an alternative vaccine to Dryvax, which contains a live virus called Vaccinia that carries a high risk of adverse complications for people with suppressed immune systems.

Smallpox, a devastating disease caused by the Variola virus, was eradicated in 1979 through the efforts of the World Health Organization (WHO). Currently, infectious Variola (a species of the genus Orthopoxvirus) is known to exist only in two WHO-sanctioned repositories, one in Russia and the other at the Centers for Disease Control and Prevention in Atlanta. However, there is concern that undisclosed reference stocks of the virus may exist, and its potential as a biological weapon has led to the production and stockpiling of smallpox vaccine and the immunization of some healthcare workers.

Because Variola no longer occurs naturally, vaccines cannot be tested for their ability to prevent smallpox in humans. Thus, licensing of future vaccine candidates will include studies of immune response and protection in nonhuman primates. According to the authors, monkeypox currently provides the best nonhuman primate model of an Orthopoxvirus infection.

MVA is made from the same Vaccinia virus present in the Dryvax product. The difference is that MVA is extremely at
'"/>

Contact: Caree Vander Linden
Caree.Vander-Linden@amedd.army.mil
301-619-2285
US Army Medical Research Institute of Infectious Diseases
10-Mar-2004


Page: 1 2

Related biology news :

1. Experimental drug shown to block mutant protein causing blood disease
2. Experimental smallpox DNA vaccine protects primates from lethal monkeypox
3. Experimental Biology 2004 - Translating the Genome
4. Experimental Biology 2004 meets in Washington, D.C. April 17-21
5. Experimental hantavirus vaccine elicits strong antibody response in primates
6. Experimental cancer drugs may halt events that lead to cardiac hypertrophy and heart failure
7. Experimental Biology 2003 meets in San Diego April 11-15
8. Experimental Biology 2003 meets in San Diego April 11-15
9. Experimental gene switch increases lifespan with no ill effects
10. Experimental therapy stops allergic reactions in mice
11. APS awards 44 minority travel fellowships to the Experimental Biology 2002 meeting

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/16/2019)... ... June 14, 2019 , ... ... customer, will deliver a joint presentation with Versiti’s CIO at the Healthcare ... the Rosen Shingle Creek Resort. , Versiti Vice President and Chief Information Officer, ...
(Date:6/13/2019)... ... June 13, 2019 , ... KICVentures announced today its ... Spine, Orthopedic and Pain Management-Driven ASC Conference in Chicago on Thursday, June 13th at ... Wacker Dr. Chicago, IL in the 3rd floor Ticino Hospitality room in space #74T. ...
(Date:6/11/2019)... Zealand (PRWEB) , ... June 12, 2019 , ... ... range of antibody discovery services, Abveris plans to leverage the Geneious Biologics platform ... Dr. Colby Souders, Chief Technology Officer at Abveris, says: “The Geneious team has ...
Breaking Biology News(10 mins):
(Date:5/14/2019)... ... May 14, 2019 , ... Gateway Genomics , a leading ... space from 2,500 to 5,000 square feet. , “This past year has seen ... says Gateway Genomics CEO, Chris Jacob. “The SneakPeek At-Home test, which is mailed directly ...
(Date:5/4/2019)... ... May 03, 2019 , ... More than three ... Pesquisas Association, the scientist and ufologist Urandir Fernandes de Oliveira, last Thursday (25), ... the results of some research carried out by the association, in partnership with ...
(Date:5/2/2019)... S.D. (PRWEB) , ... April 30, 2019 , ... The ... from industrial scale macro breweries to local craft breweries, and even home brewing clubs ... very complex chemical and biological processes, that when mastered can produce a superb product. ...
(Date:5/2/2019)... BOSTON (PRWEB) , ... May 02, 2019 , ... ... hair transplantation clinic in the greater Boston area. Gone are the days of ... The ARTAS® iX Robotic Hair Restoration System is the only robotic intelligent solution ...
Breaking Biology Technology:
Cached News: