Experimental smallpox vaccine protects against monkeypox in nonhuman primates

tenuated, or weakened, so it causes no adverse effects--even when given in high doses to immune-deficient nonhuman primates.

In the study, investigators divided 24 cynomolgous monkeys into four groups. Group 1 received two injections of MVA, two months apart; Group 2 received one injection of MVA followed by inoculation with Dryvax two months later; Group 3 received nothing at baseline and one Dryvax inoculation two months later; and Group 4 served as the unimmunized control group.

Following the MVA and Dryvax immunizations, the team measured the immune responses of the monkeys. Results showed that after two doses of MVA or one dose of MVA followed by Dryvax, the animals' immune responses were equivalent to or higher than those induced by Dryvax alone.

Two months after the last immunization, each of the 24 monkeys was challenged by intravenous injection of monkeypox virus. The unvaccinated animals became ill or died, showing signs of fever, pox lesions, weight loss, and reduced activity. The vaccinated animals were healthy overall, though minor skin lesions were seen in the group that received MVA alone and were then challenged.

According to the authors, MVA has potential use as a replacement for Dryvax, given that the immune responses elicited by one or two doses of MVA approach those of the licensed product. In addition, MVA could be useful as a pre-vaccine to Dryvax, reducing the local reaction to a subsequent smallpox vaccination without diminishing the total immune response. Further studies are planned to determine the longevity of protection, the dosage effects, and other factors.

"This work is the result of a productive collaboration between federal and academic partners," said Colonel Erik A. Henchal, commander of USAMRIID. "These are the relationships that will, in the future, deliver the biodefense products the nation needs."


Contact: Caree Vander Linden
US Army Medical Research Institute of Infectious Diseases

Page: 1 2

Related biology news :

1. Experimental drug shown to block mutant protein causing blood disease
2. Experimental smallpox DNA vaccine protects primates from lethal monkeypox
3. Experimental Biology 2004 - Translating the Genome
4. Experimental Biology 2004 meets in Washington, D.C. April 17-21
5. Experimental hantavirus vaccine elicits strong antibody response in primates
6. Experimental cancer drugs may halt events that lead to cardiac hypertrophy and heart failure
7. Experimental Biology 2003 meets in San Diego April 11-15
8. Experimental Biology 2003 meets in San Diego April 11-15
9. Experimental gene switch increases lifespan with no ill effects
10. Experimental therapy stops allergic reactions in mice
11. APS awards 44 minority travel fellowships to the Experimental Biology 2002 meeting

Post Your Comments:

(Date:6/6/2019)... ... 05, 2019 , ... Pelican BioThermal , the global ... service center in Mexico City, Mexico. Mexico is the second largest pharmaceutical market ... $1.75 billion in pharmaceutical exports since 2015. The Mexico City network station will ...
(Date:6/4/2019)... ... June 04, 2019 , ... ... salient features of seizure risk signals, usually based on variations of amplitude, frequency ... the only acceptable diagnostic methodology due to the complexity and variability of the ...
(Date:5/31/2019)... ... May 30, 2019 , ... Researchers ... Mayo Clinic, have documented significant differences in the prevalence of hereditary genetic mutations, ... compared to non-Hispanic White women. Results will be presented at the 2019 American ...
Breaking Biology News(10 mins):
(Date:5/15/2019)... ... May 16, 2019 , ... Emulsifiers are the magic bullet ... products rely on these ingredients to create stable quality food that can withstand ... shift triggers food formulators to seek out alternatives for starches, gums and chemical ...
(Date:5/7/2019)... ... May 06, 2019 , ... ... for the growing number of repositories being asked to store cellular products ... the team of contributors who are world leaders, who have shared their expertise ...
(Date:5/2/2019)... S.D. (PRWEB) , ... April 30, 2019 , ... The ... from industrial scale macro breweries to local craft breweries, and even home brewing clubs ... very complex chemical and biological processes, that when mastered can produce a superb product. ...
(Date:4/25/2019)... ... 2019 , ... Frank is an albino, deaf Great Dane. His owners rescued him when he ... health issues. Despite his hearing impairment, he was always an active and playful pup. Frank ... day, every day. As the two grew, playtime became rougher and Frank ended up injuring ...
Breaking Biology Technology:
Cached News: