Experiments offer major clue to repairing diseased nerves

CHAPEL HILL -- Using specially designed and bred laboratory mice, scientists at the University of North Carolina at Chapel Hill have discovered that a well-known protein in the body called tumor necrosis factor-alpha plays a central role in how nerves and the brain repair themselves.

The discovery is a surprise, the UNC School of Medicine researchers say, because the protein, a cytokine produced during inflammation, has traditionally been considered something that makes illnesses worse, not better. Taking advantage of the new knowledge potentially could lead to more effective treatments for such illnesses as multiple sclerosis.

"Were far from using this in any way to help patients directly, and we dont want to get hopes up prematurely," said Dr. Jenny P.-Y. Ting, Alumni Distinguished professor of microbiology and immunology at the Lineberger Comprehensive Cancer Center and the neurobiology curriculum. "Still, this is a different way of thinking about remyelination that undoubtedly will be useful and important in the future."

Remyelination is the repair process in the brain by which nerve cells regain the natural fatty sheath, called myelin, that surrounds them and allows them to transmit nerve impulses, Ting said. It often occurs to varying degrees in people with multiple sclerosis and other brain illnesses who have suffered demylination. That disease process involves the loss of fat covering nerves -- something like rubber insulation eroded away from electric wires.

A report on the findings will appear in the November issue of Nature Neuroscience and was posted online Oct. 15. Besides Ting, authors include doctoral student and first author Heather A. Arnett, Dr. Glenn K. Matsushima, assistant professor of microbiology and immunology, and Dr. Kinuko Suzuki, professor of pathology and laboratory medicine, all of UNCs Neuroscience Center.

In their experiments, the team relied on an existing mouse model of demyelination

Contact: David Williamson
University of North Carolina at Chapel Hill

Page: 1 2 3

Related biology news :

1. Experiments establish protein-only nature of prion infections
2. Experiments reveal ancient blood flow map
3. Experiments point to new theory of skeletal development
4. Experiments illuminate workings of biological clocks
5. Protestors Are Up In Arms Over Experiments That Give Chimps AIDS
6. Successful Hemophilia B Gene Therapy In Dogs May Justify Human Experiments
7. Biologist Experiments With His Own Front Yard
8. Lake research offers clues to managing crayfish invasions
9. Comparing primate genomes offers insight into human evolution
10. UW study: Migrating birds offer insight into sleep
11. Only 21 states offer newborn screening tests recommended by March of Dimes

Post Your Comments:

(Date:9/14/2019)... ... September 12, 2019 , ... ... solutions for drugs, biologics, gene therapies, and consumer health products, today announced that ... biologics business. Dr. Schaffer has played an integral advisory role on the gene ...
(Date:9/11/2019)... ... 2019 , ... Greenberg Traurig, LLP attorneys Stephen Baird , ... at DeviceTalks Minnesota, Sept. 9-10, at the Hyatt Regency, Minneapolis. Greenberg Traurig is a ... Medical Technology Group have been featured speakers at every DeviceTalks conference since 2011. ...
(Date:9/8/2019)... ... September 06, 2019 , ... ... human mesenchymal stem/stromal cell (hMSC) biomanufacturing systems, today announces its release of ... and media system designed for product development. RoosterBio continues to simplify MSC ...
Breaking Biology News(10 mins):
(Date:10/10/2019)... ... October 09, 2019 , ... As World Mental Health Day ... high school students have improved neuro-cognitive executive skills to enhance learning and academics, ... apply lifelong social/interpersonal, leadership, problem-solving and coping skills, due to an innovative program ...
(Date:10/8/2019)... ... October 08, 2019 , ... Today, Massachusetts stem cell biotechnology company ... technology. Like the company’s precursor patent, approved in the U.S. in 2017, the ... stem cells. Asymmetrex now markets the technology in the U.S. as the AlphaSTEM ...
(Date:10/3/2019)... FAIRFAX, Va. (PRWEB) , ... October 02, 2019 , ... ... the prestigious NHS Digital Health Accelerator run by the East Midlands Academic Health Science ... up the adoption of technology in NHS by providing support to develop and deploy ...
(Date:9/24/2019)... ... September 24, 2019 , ... Drug resistance has been declared as one of ... MRSA becoming one of the most serious concerns. Hong Kong cannot be spared from ... MRSA (CA-MRSA), or a seven-fold of the figure in 2007 – the year the ...
Breaking Biology Technology:
Cached News: