HOME >> BIOLOGY >> NEWS
Experiments reveal ancient blood flow map

Scientists studying how developing blood cells migrate to their proper destinations in fruit flies have discovered the ancestral role of a protein better known for ensuring that tumors have adequate blood supply. The protein, called vascular endothelial growth factor (VEGF), has gained notoriety for guiding the development of new blood vessels that nourish cancerous tumors. When researchers block VEGF, the tumors blood supply is cut off because new blood vessels dont form.

Now scientists say that VEGF and its receptors also help direct individual blood cells to their destinations in developing fruit fly embryos. The researchers say that this may be VEGFs ancient function, and that only recently in evolutionary time did VEGF assume its role in blood vessel development. The results even suggest that ancestral blood cells may have evolved into blood vessels, says Howard Hughes Medical Institute investigator Mark A. Krasnow at Stanford University.

Nobody knows how blood vessels evolved, he said. Our idea is that some population of blood cells acquired the ability to form tubular structures through which the rest of blood cells could then move. Eventually the tubules invaded the heart to form the closed circulatory system that we know today.

Nam Cho, Krasnow and colleagues at Stanford University, and Felix Karim and colleagues at the South San Francisco-based biotechnology company Exelixis Incorporated reported their findings in the March 22, 2002, issue of the journal Cell.

Migration of mammalian blood cells in adult physiology has been studied intensely, but the really amazing long distance migration of blood cells during embryonic development, which appears to be a highly programmed process, is not understood at all, said Krasnow. We believe we have discovered a molecular basis for long-range blood cell migration.

The scientists first identified four
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
28-Mar-2002


Page: 1 2 3

Related biology news :

1. Experiments establish protein-only nature of prion infections
2. Experiments offer major clue to repairing diseased nerves
3. Experiments point to new theory of skeletal development
4. Experiments illuminate workings of biological clocks
5. Protestors Are Up In Arms Over Experiments That Give Chimps AIDS
6. Successful Hemophilia B Gene Therapy In Dogs May Justify Human Experiments
7. Biologist Experiments With His Own Front Yard
8. DNA lends scientists a hand, revealing new chemical reactions
9. Award winning researchers reveal potential new role for Glivec
10. Hidden diversity: DNA barcoding reveals a common butterfly is actually 10 different species
11. Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2016)... , Feb. 2, 2016  BioMEMS devices ... primarily focused on medical screening and diagnostic ... parameters. Wearable devices that facilitate and assure ... of movement are being bolstered through new ... biomedical signal acquisition coupled with wireless connectivity ...
(Date:2/2/2016)... YORK , Feb. 2, 2016 Technology Enhancements ... presents an analysis of the digital and computed radiography ... Malaysia , and Indonesia ... trends and market size, as well as regional market ... country and discusses market penetration and market attractiveness, both ...
(Date:2/1/2016)... 2016 Rising sales of consumer ... touchfree intuitive gesture control market size ... of consumer electronics coupled with new technological advancements to ... size through 2020   --> ... technological advancements to drive global touchfree intuitive gesture control ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... is introducing a hybrid membership model which will provide ... joining or renewing through an organizational purchasing model. For ... employee in any size association or AMC office can ... benefits.   John H. Graham, IV , ... organizations of any size and their employees to gain ...
(Date:2/10/2016)... Wash., Feb. 10, 2016  IsoRay, Inc. (NYSE MKT: ... brachytherapy and medical radioisotope applications for the treatment of ... today announced its financial results for the second quarter ... 31, 2015. --> ... quarter of fiscal 2016, which ended December 31, 2015, ...
(Date:2/10/2016)... Feb. 10, 2016  Matchbook, Inc., a company ... growing biotech companies, announced today the appointment of ... Advisor. Jim brings nearly 25 years of experience ... having spent nearly two decades in executive level ... Procurement at Genzyme and, most recently headed global ...
(Date:2/10/2016)... ... February 10, 2016 , ... HOLLOWAY AMERICA, a ... Engineering (ISPE) Rocky Mountain Chapter 21st Annual Vendor Exhibition on Thursday, February 18, ... 100 tables for its annual event, which will run from 3:00 p.m. - ...
Breaking Biology Technology:
Cached News: