HOME >> BIOLOGY >> NEWS
Experiments reveal ancient blood flow map

Scientists studying how developing blood cells migrate to their proper destinations in fruit flies have discovered the ancestral role of a protein better known for ensuring that tumors have adequate blood supply. The protein, called vascular endothelial growth factor (VEGF), has gained notoriety for guiding the development of new blood vessels that nourish cancerous tumors. When researchers block VEGF, the tumors blood supply is cut off because new blood vessels dont form.

Now scientists say that VEGF and its receptors also help direct individual blood cells to their destinations in developing fruit fly embryos. The researchers say that this may be VEGFs ancient function, and that only recently in evolutionary time did VEGF assume its role in blood vessel development. The results even suggest that ancestral blood cells may have evolved into blood vessels, says Howard Hughes Medical Institute investigator Mark A. Krasnow at Stanford University.

Nobody knows how blood vessels evolved, he said. Our idea is that some population of blood cells acquired the ability to form tubular structures through which the rest of blood cells could then move. Eventually the tubules invaded the heart to form the closed circulatory system that we know today.

Nam Cho, Krasnow and colleagues at Stanford University, and Felix Karim and colleagues at the South San Francisco-based biotechnology company Exelixis Incorporated reported their findings in the March 22, 2002, issue of the journal Cell.

Migration of mammalian blood cells in adult physiology has been studied intensely, but the really amazing long distance migration of blood cells during embryonic development, which appears to be a highly programmed process, is not understood at all, said Krasnow. We believe we have discovered a molecular basis for long-range blood cell migration.

The scientists first identified four
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
28-Mar-2002


Page: 1 2 3

Related biology news :

1. Experiments establish protein-only nature of prion infections
2. Experiments offer major clue to repairing diseased nerves
3. Experiments point to new theory of skeletal development
4. Experiments illuminate workings of biological clocks
5. Protestors Are Up In Arms Over Experiments That Give Chimps AIDS
6. Successful Hemophilia B Gene Therapy In Dogs May Justify Human Experiments
7. Biologist Experiments With His Own Front Yard
8. DNA lends scientists a hand, revealing new chemical reactions
9. Award winning researchers reveal potential new role for Glivec
10. Hidden diversity: DNA barcoding reveals a common butterfly is actually 10 different species
11. Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Experiments reveal ancient blood flow map

(Date:5/19/2015)... , May 19, 2015 ... has announced the addition of the  "Genetic ... offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,A recent ... an in-depth analysis of the current and ... of gene-based tests, their working principles and ...
(Date:5/14/2015)... NEW YORK , May 14, 2015 ... specializing in identity verification and online remote ... Instructure, a software-as-a-service (SaaS) company and creator ... Shared customers of the two companies will ... Proctortrack in Canvas. As a ...
(Date:5/11/2015)... Curemark LLC, a privately held drug research ... Phase III double blind, randomized, placebo-controlled clinical trial to ... all children ages 3-8 with Autism. Previously, Curemark announced ... blinded clinical trial for CM-AT in children ages 3-8 ... enzyme chymotrypsin. This new trial will help determine whether ...
Breaking Biology News(10 mins):Global Genetic Testing Market Outlook 2018 2Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2
(Date:5/21/2015)... 2015 W. R. Grace & ... in Worms, Germany has received good manufacturing practice ... the International Pharmaceutical Excipient Council (IPEC) Foundation. ... its SYLOID® FP brand of pharmaceutical grade excipient ... the Curtis Bay, Maryland (USA) and Sorocaba, Brazil ...
(Date:5/21/2015)... 2015 Research and Markets ( ... "2015 Global Survey on Flow Cytometry Adoption ... The primary goal of this research is to ... reagents. Key information the survey seeks to collect ... cytometers, predominantly used applications for flow cytometers, respondents, ...
(Date:5/20/2015)... , May 20, 2015 Veracyte, ... preliminary data demonstrating the ability of the company,s ... (IPF) from other interstitial lung diseases (ILDs) using ... classifier,s potential to help thousands of patients avoid ... in IPF diagnosis – a frequent challenge for ...
(Date:5/20/2015)... Pa. , May 20, 2015  Select ... that the Federal Trade Commission granted early termination ... Antitrust Improvements Act of 1976, as amended, applicable ... MJ Acquisition Corporation, a joint venture that Select ... L.P. As previously announced, MJ Acquisition ...
Breaking Biology Technology:Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2Global Survey on Flow Cytometry Adoption Trends 2015 2Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 2Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 3Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 4Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 5Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2
Cached News: