HOME >> BIOLOGY >> NEWS
Experiments reveal ancient blood flow map

Scientists studying how developing blood cells migrate to their proper destinations in fruit flies have discovered the ancestral role of a protein better known for ensuring that tumors have adequate blood supply. The protein, called vascular endothelial growth factor (VEGF), has gained notoriety for guiding the development of new blood vessels that nourish cancerous tumors. When researchers block VEGF, the tumors blood supply is cut off because new blood vessels dont form.

Now scientists say that VEGF and its receptors also help direct individual blood cells to their destinations in developing fruit fly embryos. The researchers say that this may be VEGFs ancient function, and that only recently in evolutionary time did VEGF assume its role in blood vessel development. The results even suggest that ancestral blood cells may have evolved into blood vessels, says Howard Hughes Medical Institute investigator Mark A. Krasnow at Stanford University.

Nobody knows how blood vessels evolved, he said. Our idea is that some population of blood cells acquired the ability to form tubular structures through which the rest of blood cells could then move. Eventually the tubules invaded the heart to form the closed circulatory system that we know today.

Nam Cho, Krasnow and colleagues at Stanford University, and Felix Karim and colleagues at the South San Francisco-based biotechnology company Exelixis Incorporated reported their findings in the March 22, 2002, issue of the journal Cell.

Migration of mammalian blood cells in adult physiology has been studied intensely, but the really amazing long distance migration of blood cells during embryonic development, which appears to be a highly programmed process, is not understood at all, said Krasnow. We believe we have discovered a molecular basis for long-range blood cell migration.

The scientists first identified four
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
28-Mar-2002


Page: 1 2 3

Related biology news :

1. Experiments establish protein-only nature of prion infections
2. Experiments offer major clue to repairing diseased nerves
3. Experiments point to new theory of skeletal development
4. Experiments illuminate workings of biological clocks
5. Protestors Are Up In Arms Over Experiments That Give Chimps AIDS
6. Successful Hemophilia B Gene Therapy In Dogs May Justify Human Experiments
7. Biologist Experiments With His Own Front Yard
8. DNA lends scientists a hand, revealing new chemical reactions
9. Award winning researchers reveal potential new role for Glivec
10. Hidden diversity: DNA barcoding reveals a common butterfly is actually 10 different species
11. Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Experiments reveal ancient blood flow map

(Date:3/26/2015)... , March 26, 2015 The ... social, recreation and athletic club, today announced it has ... allow freedom of movement for members and staff, while ... a comprehensive process, we selected FST,s IMID Access system ... convenience for our members and staff, in addition to ...
(Date:3/23/2015)... 23, 2015 SoundView Technology Group issues a new ... NXTD ) Wocket smart wallet. SoundView was one of the selected ... experience with the Wocket in multiple scenarios and outlets. ... and other retailers, making both debit and credit card payments.  ... says, "If the company meets their plans in 2015, it ...
(Date:3/20/2015)... DUBLIN , Mar. 19, 2015 Research and Markets ... the "Hand Geometry - Global Strategic Business Report" ... worldwide markets for Hand Geometry in US$ Thousands. The report ... , Japan , Europe ... America , and Rest of World. Annual ...
Breaking Biology News(10 mins):Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4
(Date:4/24/2015)... , April 24, 2015 /PRNewswire/ - BioAmber Inc. ... Bayer MaterialScience as the supplier of bio-succinic acid ... bio-based polyurethanes for textile applications that Bayer MaterialScience ... has launched IMPRANIL ® eco, a series ... that reaches as high as 65%.  IMPRANIL ® ...
(Date:4/24/2015)... April 24, 2015 Seoul Semiconductor ... for various applications in the lighting market. ... installations of this technology in emerging markets such ... a wide range of applications such as streetlight ... decorative lighting. , First launched in 2005 the ...
(Date:4/23/2015)... -- BioTE Medical President and Founder Gary Donovitz ... - Avoiding Over-Medication through Natural Hormone Balance" (ISBN: 9780990706458) ... at JW Marriott / Ritz Carlton Grande Lakes April ... Happier, is a welcomed response to many men and ... higher quality of life thanks to bio-identical hormone replacement ...
(Date:4/23/2015)... , April 23, 2015  Cryoport, Inc. (OTCBB: ... logistics solutions for the life sciences industry, today ... cryogenic logistics solutions within the animal husbandry market ... Farms to support the shipment of equine semen ... horse Stallions. Animal husbandry is ...
Breaking Biology Technology:Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 2Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 3Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 4Acrich Technology from Seoul Semiconductor Adopted in Installations Worldwide 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 3Cryoport to Support the Equine Animal Husbandry Market Through Agreement with Yancey Farms 2Cryoport to Support the Equine Animal Husbandry Market Through Agreement with Yancey Farms 3
Cached News: