HOME >> BIOLOGY >> NEWS
Explaining the persistence of Hepatitis C

Hahn and colleagues previously showed that of the major Hepatitis C virus (HCV) proteins, only one, the nucleocapsid core protein, can confer on a carrier virus the ability to evade the host animal's immune system. Because this finding might help explain the long-term viral persistence that makes hepatitis C intractable, this group has now screened for lymphocyte proteins that can interact specifically with the viral core protein. Here they show that gC1qR, a receptor for complement protein C1q, is one such binding partner for core protein, and they identify the domains required on each protein that allow for this interaction. C1q, the endogenous ligand for this receptor, is also known to suppress T cell function, although C1q and the HCV core protein bind distinct sites on the gC1qR. Kittlesen et al. confirm that purified core protein blocks T-cell proliferation in a cell culture assay. They also show that a blocking antibodies to the core protein or to gC1qR can abolish this effect, raising the question of why endogenous anti-core antibodies do not have a similar protective effect in infected individuals. Nonetheless, in light of the earlier finding that an active T-cell response to core protein correlates with suppression of HCV, the present work may open the door to developing immune or other therapies for chronic hepatitis C.


'"/>

Contact: John Ashkenas
scied@the-jci.org
206-221-5690
Journal of Clinical Investigation
12-Nov-2000


Page: 1

Related biology news :

1. Explaining how ozone "chokes up" plants
2. Scientists surprised at persistence of nitrate from dated experiment
3. Key to hepatitis virus persistence found
4. Researchers find key to tuberculosis persistence in the body
5. Wisconsin lake study shows persistence of acid rain effects
6. Risk of Hepatitis E from consumption of deer?
7. Hepatitis C infection does not alter HIV progression or treatment
8. Need, potential for Hepatitis C vaccine highlighted by Hopkins study
9. Hepatitis E recovered from rats in Los Angeles
10. Hepatitis C drug overwhelms virus with flood of mutations - surprising mechanism may improve anti-viral treatments, UCSF study finds
11. High percentage of Hepatitis C patients take herbs and vitamins, according to Rush survey

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... -- Today HYPR Corp. , leading innovator in ... the HYPR platform is officially FIDO® Certified . ... that empowers biometric authentication across Fortune 500 enterprises and ... 15 million users across the financial services industry, however ... suites and physical access represent a growing portion of ...
(Date:3/30/2017)...  On April 6-7, 2017, Sequencing.com will host the ... hackathon at Microsoft,s headquarters in Redmond, Washington ... developing health and wellness apps that provide a unique, ... is the first hackathon for personal genomics and ... in the genomics, tech and health industries are sending ...
(Date:3/28/2017)... The report "Video Surveillance Market ... Storage Devices), Software (Video Analytics, VMS), and Service (VSaaS, ... to 2022", published by MarketsandMarkets, the market was valued ... to reach USD 75.64 Billion by 2022, at a ... year considered for the study is 2016 and the ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are the ... million people each year. Especially those living in larger cities are affected by air ... one of the most pollution-affected countries globally - decided to take action. , “I ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that ... Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital Los ...
(Date:10/10/2017)... , Oct. 10, 2017 SomaGenics announced ... the NIH to develop RealSeq®-SC (Single Cell), expected to ... profiling small RNAs (including microRNAs) from single cells using ... highlights the need to accelerate development of approaches to ... "New techniques for measuring levels of ...
(Date:10/9/2017)... , ... October 09, 2017 , ... The award-winning American ... broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , ... faced with the challenge of how to continue to feed a growing nation. At ...
Breaking Biology Technology:
Cached News: