HOME >> BIOLOGY >> NEWS
Extreme stretch-growth of axons

"

These extreme rates of growth are not consistent with the current understanding of the limitations of axon growth. "Proteins necessary to sustain this growth are somehow correctly brought to sites along the axon faster than conceivable rates of transport," notes Smith. The team suggests two possible mechanisms to explain this: increasing transport to a very fast rate or making the necessary proteins at the site, proximal to the growing axons. Smith believes that this form of growth commonly occurs in nature. "For example, it can be inferred that axons in a blue whale's spine grow more than three centimeters a day and in a giraffe's neck at two centimeters a day at peak growth."

The team also found that they had to condition the axons to grow in an extreme way. "Although they can handle enormous growth, you can't just spring it on them," explains Bryan Pfister, PhD a post-doctoral fellow in Smith's lab and coauthor of the study. "If we ramp up the stretch rate too fast, the axons will snap." From this the team surmises that in nature animals must grow at a metered pace, which allows for constant feedback and conditioning.

It has been well established that axons initially grow out from neurons and follow a chemical stimulus to connect with another neuron. However, once the axon has reached its target a relatively unknown form of stretch-growth must ensue as the animal grows. Mechanical changes in the growing brain, spine, and other bones are the starting point for natural stretch-growth in axons. "We know that it's not tension on the neuron itself, but tension on the axon," says Smith. "It's deformation, a pulling on the axon." At this point, it is unclear what receptors and cell signaling pathways are involved to get the process started, but from this and previous studies the investigators do report that the signal is from a mechanical stimulus along the length of the axon as opposed to a chemical stimulus. "The stretch is coming from
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
7-Sep-2004


Page: 1 2 3

Related biology news :

1. Extreme 2003 takes students worldwide to the oceans depth
2. Extreme climate variance sped extinction of local butterfly populations, researchers say
3. For First Time In 40 Years National Jewish Researchers Report Chronic Beryllium Disease Caused By Extremely Low Levels Of Exposure
4. The Fire Down Below: Extreme Heat-Loving Organisms May Be Keys To Molecular Evolution, Origin Of Life, New Book Argues
5. Virginia Tech Scientists Studying Cells From Extreme Environments
6. Plakin proteins brace nerve axons and allow for the transport of neurotransmitter vesicles

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/10/2016)... March 10, 2016   Unisys Corporation (NYSE: ... Protection (CBP) is testing its biometric identity solution at ... to help identify certain non-U.S. citizens leaving the ... test, designed to help determine the efficiency and accuracy of ... February and will run until May 2016. --> ...
(Date:3/9/2016)... BEACH GARDENS, Fla. , March 9, 2016 ... identity management authentication and enrollment solutions, today announced ... DigitalPersona ® Altus multi-factor authentication ... IT and InfoSec managers to step-up security where ... Washington, DC . ...
(Date:3/3/2016)... , March 3, 2016  2016FLEX, organized by ... week highlighting advancements in flexible, hybrid and printed ... setting attendance - have gathered for short courses, ... field of electronics. The Flex Conference celebrates its ... for companies, R&D organizations, and universities contributing to ...
Breaking Biology News(10 mins):
(Date:5/26/2016)... May 26, 2016 Q BioMed Inc. ... will be a featured presenter at the 5th Annual Marcum ... New York City at the Grand Hyatt Hotel. ... Q BioMed Inc. CEO, is scheduled to begin at 11a.m ... company,s business strategy, recent developments and outline milestones for the ...
(Date:5/25/2016)... ... May 25, 2016 , ... Lajollacooks4u has become a rising hotspot for ... one of its top attractions. Fortune 500 companies, such as Illumina, Hewlett-Packard, Qualcomm ... and intimate team-building experience. , Each event kicks off with an olive oil and ...
(Date:5/25/2016)... ... ... at the University of Athens say they have evidence that the variety of different ... lead to one good one. Surviving Mesothelioma has just posted an article on the ... 98 mesothelioma patients who got a second kind of drug therapy after ...
(Date:5/24/2016)... 24, 2016   MedyMatch Technology Ltd ., the data ... real-time decision support tools in the emergency room, announced today ... Israeli Advanced Technology Industries (IATI) BioMed Conference. ... 15th National Life Sciences and Technology Week, and is ... Hotel in Tel Aviv, Israel . ...
Breaking Biology Technology:
Cached News: