HOME >> BIOLOGY >> NEWS
FDA mandate for folic acid fortification may decrease the incidence of Down syndrome

Increasing folate levels in women prior to conception -- which could be achieved either through fortified foods, natural dietary sources, or vitamin supplementation -- may reduce the incidence of Down syndrome, according to a study funded by the United States Food and Drug Administration (US-FDA) Office of Women's Health.

Down syndrome is a genetic condition usually caused by an error in chromosome segregation in the mother's egg. Normal human cells contain 23 pairs of chromosomes, but Down syndrome cells contain three copies of chromosome 21 -- a condition known as trisomy 21. In the United States, trisomy 21 occurs in about 1 out every 150 conceptions; 80% result in miscarriage and 20% result in babies born with Down syndrome.

Folate, also called folic acid, is a B vitamin found naturally in leafy dark green vegetables, beans, peas, liver, and orange juice. Previous studies have proven that inadequate folate status at the time of conception increases the risk of neural tube defects such as spina bifida -- the leading cause of childhood paralysis. In 1998, the US-FDA mandated that 140 micrograms of folic acid be added to every 100 grams of enriched grain products such as pasta, breakfast cereals, and flour. This mandate was intended to increase the amount of folic acid in the typical American diet and ultimately to reduce the incidence of birth defects.

This study, published in the American Journal of Clinical Nutrition, showed that mothers of babies with Down syndrome often have the same genetic abnormality in folate metabolism associated with spina bifida. The study suggests that the FDA's mandate to fortify foods with folic acid may have additional long-term health benefits. Says lead author S. Jill James, PhD, at the FDA-National Center for Toxicological Research, "Our preliminary research is promising, however, a larger clinical study is needed to determine whether folic acid supplementation 2 to 3 months prior to conception will reduce the
'"/>

Contact: Jill James, PhD
jjames@nctr.fda.gov
870-543-7306
American Society for Clinical Nutrition/American Society for Nutritional Sciences
13-Oct-1999


Page: 1 2

Related biology news :

1. Scientists developing strategies for upcoming phosphorus mandates
2. Fortifying food with folic acid benefits babies
3. Fortification of food supply with folic acid
4. Sick Kids researchers link maternal folic acid intake to decrease in deadly childhood cancer
5. Dutch diet contains too little folic acid
6. Penn study finds signs folic acid and Vitamin B12 may lessen some ill effects of SMA
7. Using new FDA regulations, Kellogg takes the lead in promoting heart-health benefits of folic acid
8. New mouse model could be key to understanding role of folic acid in preventing birth defects
9. Food fortification spurred by military purchases
10. Enzyme maintaining chromosome ends is linked to bone cancer recurrence, decreased survival
11. Calcium supplements associated with decreased risk of large bowel polyps

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: